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15,626 grants found
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Understanding the multifunctional fungi that connect fields and streams
Aquatic hyphomycete fungi are important in streams because they make carbon from plant debris available to the stream food web. Some species, including species in the genus Tetracl...
Diabetes subclassification - new genes and novel mechanisms
In 2018 we suggested a new subclassification of diabetes, including five subtypes with differing progression and risk of diabetic complications. In this project we will further cha...
Obstructive sleep apnea during REM-sleep – effects on cardiometabolic outcomes, inflammation and possible gender differences
It is well-known that obstructive sleep apnea (OSA) is followed by cardiometabolic diseases and mortality but interventional studies have failed. Based on our own previous results...
Investigation of cardiac remodeling and tissue characteristics using advanced CMR and multiplex proteomics for optimized assessment and treatment of atrial fibrillation
Bakgrund: Förmaksflimmer (FF) är hjärtarytmin med högst prevalens i världen och kan leda till livshotande komplikationer som t ex hjärtsvikt, stroke och död. Fortfarande föreligge...
Alpha particle radiopharmaceuticals from bench to bedside
The multidisciplinary competence in the Targeted Alpha Therapy (TAT) group and associated clinicians at the Sahlgrenska University Hospital, (Oncology, Radiation therapy, Gynecolog...
Relative Concerns and Social Exclusion: Economic Policy and Human Capital in an Interdependent World
Modern theory of optimal redistributive taxation and public expenditures largely neglects empirics showing that people’s utility does not only depend on their own consumption (broa...
Behandling av hjärtinfarkt med angiografiskt normala kranskärl med kognitiv beteendeterapi
Bakgrund: Hjärtinfarkt med angiografiskt normala kranskärl, det vill säga när orsaken till hjärtinfarkten inte beror på kärlförträngningar, är vanligt (6-8 % av alla hjärtinfarkter...
MRTF-SRF signaling in vascular disease
Bakgrund:Myokardin-lika koaktivatorer (MRTFs) är transkriptionsfaktorer som spelar roll vid kardiovaskulära sjukdomstillstånd, såsom ateroskleros och hjärtsvikt. MRTFs verkar tills...
Hyperbaric Oxygen Preconditioning to improving tissue survival after re-transplantation: A translational study aimed at increasing chances to regain fertility after cancer treatment
Introduction:With an increasing number of young cancer survivors, fertility preservation is an important quality of life issue. Cryopreservation of ovarian tissue is the only estab...
Brain development in children born too soon
Preterm birth occurs in 6-12% of pregnancies. Intensive care of preterm infants has made advance over the last decades resulting in dramatically increased survival rates for extrem...
CANCER THERAPY INDUCED DISRUPTION OF B CELL MEMORY IN THE BONE MARROW STROMAL NICHE AND SECONDARY LYMPHOID TISSUE; IMPLICATIONS FOR VACCINE RESPONSES
Aims Assess the mechanisms causing loss of B cell memory after cancer therapy.Background Re-vaccination after cancer does not always re-establish protective antibody(Ab)titers. We...
Neuronal rejuvenation through restoration of autophagy
Aging affects all humans and is the most critical parameter for quality and length of life. Aging is also by far the most critical risk factor for several neurodegenerative disorde...
Strategic Risk, Artificial Intelligence and Collusive Crime
Collusive crime involves multiple, organized wrongdoers cooperating for extended periods, and ranges from market cartels to fraud, corruption, money laundering, and drugs and human...
Rural Electrification in the Global South: Possibilities and Consequences of Renewable Energies
Rural areas in many parts of the Global South persist with poverty and lack of opportunities. One of the major challenges these areas face is the lack of electricity. The role of e...
Development, optimization and Clinical Implementation of Advanced Technologies for Detection of protein panels and Exosomes as Biomarkers–with Relevance for Prostate and Gastric Cancer
We have developed a large number of advanced molecular tools for detection and characterization of exosomes and proteins. We aim now to a) develop methods and further optimized ass...
Functionality of autoreactive B cells and autoantibodies in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease leading to synovitis and joint destruction. The autoimmunity is characterized by autoantibodies to citrullinated proteins...
The impacts of large-scale solar farms on climate and terrestrial ecosystem
Renewable energy, such as the solar energy, needs to be promoted around the world to substitute for the fossil fuels that currently still dominate worldwide energy consumption. Ide...
HYDE – Human agency and the rule of law in semi-automated decision-making systems
This project aims to generate new knowledge about the legal aspects surrounding the increased use of semi-automated decision-making in areas affecting fundamental rights. Respondin...
PUSH ME: SMS-baserad livsstilsintervention i primärvården för patienter med högt blodtryck. En randomiserad kontrollerad studie
Bakgrund: Hypertoni är en viktig riskfaktor för kardiovaskulär sjukdom och förtida död, och många hypertonipatienter når ej målblodtryck. Förbättrade levnadsvanor kan sänka blodtr...
Multifunctional stripcropping systems to optimize above- and belowground ecosystem services
Currently, monocultures that require constant pesticide and fertiliser inputs to be profitable dominate European agriculture. Alternative cropping systems need to be put in place t...