Development, optimization and Clinical Implementation of Advanced Technologies for Detection of protein panels and Exosomes as Biomarkers–with Relevance for Prostate and Gastric Cancer

We have developed a large number of advanced molecular tools for detection and characterization of exosomes and proteins.

We aim now to a) develop methods and further optimized assays to characterize and measure exosomes as promising biomarkers for prostate- and gastric cancers, and b) establish a dedicated protein panel for diagnostic of gastric cancer.As previously demonstrated, we have developed a unique set of tools enabling large-scale and multiplex protein measurement and characterization of exosomes, and we have possibility to establish extremely sensitive assays for specific detection of proteins and extracellular vesicles in body fluids, which can offer radically new opportunities for diagnostics, drug development, patient stratification, and follow-up in malignancy and other diseases.

We have developed three very sensitive and specific methods for detection of exosomes, and using our technologies we were first to demonstrate elevated levels of a prostate-specific exosome in plasma samples from prostate cancer patients.

We plan now to further validate and implement the assays for clinical use.Using sensitive multiplex proximity extension assays we have identified an 18-protein signature, distinguishing gastric cancer patient samples compared to those from controls with a sensitivity of 91% and specificity of 90%.

We aim now to establish a dedicated protein panel for diagnosis of gastric cancer after it have been validated in two independent patient cohorts.