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Genetics of preterm delivery and its cellular mechanisms: beyond genomics discoveries
Preterm delivery is the leading cause of death in children under 5-years of age and long-term child morbidity.The preterm delivery rate has not shown any notable reduction, partly...
Accessing regional health data for the study of multiple sclerosis: From predictors to precision medicine
Multiple sclerosis (MS) is a chronic disabling disease of the brain and spinal cord with an unknown aetiology.In recent years, researchers have discovered a ‘prodromal’ period befo...
Changes in chromosome numbers in pediatric leukemia: how, why and when?
Aneuploidy, i.e., changes in chromosome numbers, is a common phenomenon in cancer cells.In the proposed project I will study two types of aneuploid pediatric acute lymphoblastic le...
Illuminating neutrophils dark microproteome against fungal pathogens
The human genome contains thousands of unannotated short open reading frame (sORF) encoded microproteins, which are potential functional peptides waiting to be discovered.Despite t...
Cellular and Molecular mapping of the blood nerve barrier during health and disease
The entire central and peripheral nervous systems (CNS and PNS) are shielded from potentially neurotoxic molecules in the circulation by the blood-brain and blood-nerve barriers.Do...
Frizzleds as dynamic, pharmacological and druggable entities
Diverse signaling systems are attractive targets for anti-cancer therapy, one of which is the WNT/Frizzled signaling system, where secreted WNT proteins activate Frizzled receptors...
Spatial and single-cell proteomics of metabolic disorders
Mitochondrial metabolism is constrained by the available resources within its host cells and surrounding tissue.Enzymatic sets are dynamically expressed upon internal and external...
Common factors contributing to poor reproductive outcome from failed implantation to pregnancy loss
Motherhood holds a profound significance for many women, yet one in six couples encounters infertility. In vitro fertilization (IVF), the most common treatment, yields modest pregn...
Visualizing evolution of resistance in breast cancer tumors through In Situ Sequencing
Intratumoral heterogeneity is a critical driver of tumor resistance, as varying populations of cancer cells within a tumor can exhibit different sensitivities to treatments.This dy...
Alkoholbruk trots negativa konsekvenser: En translationell strategi
Alcohol addiction leads to continued alcohol use despite adverse consequences (“compulsivity”).We have found that a minority of outbred rats show punishment-resistant, compulsive-l...
Receptor-mediated mechanisms in Parkinson´s disease and depression
This programme aims at providing better biomarkers anbd mechanism-based therapies for two common diseases: Parkinson´s disease (PD) and Major depressive disorder (MDD). Besides mot...
Mechanisms of antiviral defense in the CNS - uncovered through patient-mimicking transgenic mice and human brain organoids
Viral infections can cause devastating diseases if not controlled by the immune system.This includes diseases in the central nervous system (CNS) where e.g. herpes simplex virus 2...
Building Bone: Harnessing Fetal Mesenchymal Stem Cells to Treat Osteogenesis Imperfecta.
Our aim is to harness the full potential of our recently developed fetal mesenchymal stem cell (fMSC) therapy.We are currently about to change the lives of people living with Osteo...
The significance of environmental and lifestyle factors for the onset and course of multiple sclerosis.
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults in Europe. The etiology is unclear. Twin studies suggest that environment and/...
BEAM-MS - Brain-resident cell Epigenetics Altered by the Metabolome to target Multiple Sclerosis
Multiple Sclerosis (MS) is a major neurological disorder, characterized by the loss of myelin around nerve axons in the central nervous system due to autoimmune attacks.Oligodendro...
To find the cause of rheumatoid arthritis using humanized mouse models with the major polymorphic genes; HLA-DR and NCF1
Purpose and objective: Investigate the cause of rheumatoid arthritis (RA) using unique mouse strains expressing the major disease-associated human alleles (DRB1 and NCF1) to develo...
IL-6 trans-signalling in HPS and HFRS pathogenesis: a treatable target?
Hantaviruses cause two severe acute diseases; hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal syndrome (HFRS). Fatality rates are 35-40% for HPS and up to 10%...
Pathogenic mechanisms and effects of treatment in chronic, idiopathic inflammatory myopathies, myositis
Myositis is a complex autoimmune disease with high morbidity and mortality. Biomarkers to predict prognosis are lacking.Newly discovered myositis specific autoantibodies predict di...
Understanding how MYC drives transcriptional amplification via regulation of DNA topology
Inhibitors of Topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy. While they have proven effective, the toxicity of current TOP drugs in non-cancer cells, limits...
Towards personalized medicine in pregnancy: Early prediction of pregnancy complications to improve maternal and fetal outcomes
Purpose.The existing antenatal care program is similar for most women with increasing frequency of visits as the pregnancy progresses, aiming to find established pregnancy complica...