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606,025 grants found
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Unravelling the Molecular Signatures of Reproductive Mood Disorders: a Multi-Omics Approach Project
The MoodMAP project targets the challenge of diagnosing and treating reproductive mood disorders (RMDs), such as premenstrual disorder and postpartum depression, which significantl...
´Stronger Together´ - Psychological support for parents of children diagnosed with cancer
Parents of children with cancer report increased levels of psychological and relationship distress.Yet, there is a lack of interventions in paediatric oncology care addressing thes...
Platform development of engineered extracellular vesicles for gene editing in the CNS
To date, there are no curative treatments for most neurodegenerative disorders, including synucleinopathies of the central nervous system (CNS) such as Parkinsons disease (PD).The...
Impact of Collective Chemical Exposome of Infertile Couples on the Likelihood of Clinical Pregnancy and Live Birth
Infertility affects 15-20% of all couples during their reproductive lifespans and is a significant couple and public health problem.Despite advanced techniques to address infertili...
Environment before adulthood in Multiple Sclerosis etiology
Through Swedish multiple sclerosis (MS) registers and microbiological biobanks crosslink, we have formed the world´s largest material with pre-symptomatically drawn serum samples....
Regulation of nuclear processes by mast cell tryptase - molecular mechanisms and disease implications
Mast cells (MCs) are versatile immune cells mostly known for their detrimental actions in allergic disease, but they have also been implicated in a range of other pathological sett...
Defining persisting brain injury after eclampsia and identifying new treatment targets to protect the maternal brain
The goal of this project is to define neurological outcomes after eclampsia and to determine underlying pathophysiological pathways to eclampsia which will lead to new drugs for ne...
Medication-wide surveillance of pregnancy drug safety in large-scale real-world data: systematic generation of missing evidence to inform clinical decision-making
Most prescription drugs lack enough evidence on their safety for use during pregnancy.Our overall aim is to systematically gather new evidence for the safety of a comprehensive ran...
A Comprehensive Molecular Map of Human Ovaries Across Life Stages for the Development of Novel Fertility and Ovarian Reserve Markers
Human fertility rates have declined below the population replacement rate in every EU member state, with the age of first-time mothers increasing to 30-years.Maternal age significa...
Is being overweight early in life a risk factor for early diagnosis of type 1 diabetes in children and, if so, does it explain the increase in T1D incidence during the Covid pandemic?
Type 1 diabetes (T1D) is one of the most common disease among children in Sweden and the incidence has doubled in recent decades. Numerous studies have reported an even higher inci...
From Mice to Patients: Preventing Joint Destruction with Anti-RANKL in Septic Arthritis
Septic arthritis presents a significant challenge in modern medicine, often leading to permanent joint dysfunction and necessitating joint replacement surgery.Our hypothesis focuse...
Strategies for countering treatment resistance in cancer by tracing and targeting clonal dynamics
Rationale: Most children dying from cancer under modern healthcare do so because of relapsing, treatment-resistant disease.The mechanisms underlying resistance are largely unexplor...
Countering stigma in self-management in people with chronic obstructive pulmonary disease: co-creation and feasibility of an intervention to improve health
People with chronic obstructive pulmonary disease, COPD, are often stigmatized due to previous long-term smoking. Stigma has been highlighted as a barrier to self-management.Still,...
Unlocking and blocking the molecular mechanisms of redox regulation in β-cells
The islets of Langerhans are the endocrine component of the pancreas and their dysfunction, in particular the β-cells, results diabetes. Currently there is no cure for diabetes. Th...
Evaluation and individualization of colorectal cancer screening in Sweden (The EVIDENCE project)
Colorectal cancer (CRC) is the third most common cancer worldwide and the most resource consuming and costly cancer.Primary and secondary prevention of CRC with screening can reduc...
Harnessing DNA Replication Stress to Overcome Treatment Resistance of high-risk Cancers
The landscape of precision medicine in cancer is on the brink of a profound shift, propelled by rapid advancements in next-generation anticancer drugs, including immuno-oncology (I...
Goblet cell intrinsic determinanats of intestinal mucus function in health and disease
Non-communicable intestinal mucosal diseases affect millions of people and are expected to rise in prevalence due to the impacts of modern lifestyle changes.Common to these disease...
Nutritional metabolomics: capturing habitual diet patterns and their relation to health outcomes in the population.
The program goal is to use nutritional metabolomics to objectively describe intake of major food groups in healthy diets, combined with self-reported intake, among individuals in l...
Tissue resident lymphocytes in severe asthma and biologics treatment
Biologics targeting type 2 cytokines offer new hope for patients with severe asthma, but not all patients respond, and none are cured. This calls for increased understanding of air...
Charting the complex molecular landscape in chronic lymphocytic leukemia: the path towards precision medicine
The proposed project aims to thoroughly map the molecular landscape of chronic lymphocytic leukemia (CLL), the most prevalent adult leukemia in Western countries.Taking advantage o...