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606,025 grants found
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CH in Aging and Exceptional Longevity
Project Summary Clonal Hematopoiesis (CH) is characterized by somatic mutations originating from a few hematopoietic stem cell clones. CH is well known to be an age associated phen...
Yakama Nation: Native Collective Research Effort to Enhance Wellness Program
Modified Project Summary/Abstract SectionThe Yakama Nation’s (YN) 31,000 residents reside on 1.4 million acres primarily within Washington state, and since 2021 there has been a 34...
2024 International Conference on Gram Positive Pathogens
Project Summary The International Conference on Gram-Positive Pathogens (ICGPP) brings together scientists at all stages of their careers to exchange ideas and research strategies...
Metabolic regulation of the stem cell niche
PROJECT SUMMARY/ABSTRACT Adult stem cells constitute a group of progenitor cells capable of tissue regeneration during life through the ability to both self-renewal and produce spe...
Cognitive, structural and functional impact of new onset type 1 diabetes on the brain of young children: Understanding risks and protective factors
An increasing body of data show the brain is a target of diabetes complications. We and others have investigated the impact of type 1 diabetes (T1D) in the developing brain in chil...
Determinants of Neurocognitive Complications in T1D
Project Summary Children with type 1 diabetes (T1D) suffer from subtle cognitive impairments and structural alterations in the brain. These impairments progress with age and may ev...
Neurocognitive Complications of Pediatric Type 1 Diabetes: Identifying Modifiable Risk and Protective Factors
PROJECT SUMMARY Children with type 1 diabetes (T1D) have small but significant deficits in neurocognitive functioning compared to their peers without diabetes, especially in the ar...
Attention and memory contributions to the maintenance of binge eating
Attention and memory contributions to the maintenance of binge eating PROJECT SUMMARY/ABSTRACT Binge eating (BE) is a transdiagnostic symptom of multiple eating disorders, includin...
Risk and Protective Factors for Neurocognitive Development in Type 1 Diabetes
Project Summary/Abstract Type 1 diabetes (T1D) in childhood may cause neurocognitive deficits which worsen over time. Declines in cognitive function may lead to suboptimal T1D mana...
Investigations of drug encapsulation in polymer nanoparticles: Training undergraduate students in multidisciplinary research
Abstract For several decades nanoparticle formulations of molecules used for diagnostics and/or therapy have been intensively developed to improve and control their bioavailability...
Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors
PROJECT SUMMARY The pathophysiology of cognitive dysfunction in prepubertal children with Type 1 Diabetes Mellitus (T1DM) is not understood. It is likely that hyperglycemia, hypogl...
Membrane cholesterol homeostasis in human brain cells derived from iPSCs
Alzheimer’s disease (AD), a major form of dementia, starts with synaptic dysfunction and progresses to massive neurodegeneration. Mutations of amyloid precursor protein (APP) that...
UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth
PROJECT SUMMARY Growing evidence suggests that individuals with Type 1 diabetes mellitus (T1D) are at risk for cognitive dysfunction over time, with approximately 28% of middle-age...
Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC)
Summary Type I diabetes (T1D) is one of the most common chronic diseases in childhood. Sequelae of pediatric T1D include neurocognitive dysfunction in attention, psychomotor speed,...
Neurocognitive Effects of Type 1 Diabetes in Young Children: Indiana University Clinical Center
PROJECT SUMMARY Many individuals living with Type 1 diabetes (T1D) experience significant cognitive impairments. These impairments are more common in people diagnosed in early chil...
Longitudinal Evaluation of Neurocognitive Complications in Pediatric Type 1 Diabetes Across Multi-Ethnic Groups—Exploring Risk and Protective Factors
PROJECT SUMMARY Our multidisciplinary team endeavors to address critical knowledge gaps regarding the impact of type 1 diabetes (T1D) on neurocognitive outcomes among a diverse pop...
Mechanisms underlying the neuroprotective effect of nasal administration of anti-CD3 in AD mouse models
In Alzheimer’s disease (AD), danger signals including dead neurons, dystrophic axons, tau and Ab alter the functional phenotype of microglia from a homeostatic (M0) to a neurodegen...
Evaluating Neurocognitive Complications of Type 1 Diabetes (T1D) and Potential Risk and Protective Factors in Pre-Pubertal Children- New York University Clinical Center
Project Summary Children with type 1 diabetes (T1D) have an increased likelihood of mild cognitive dysfunction and altered brain development compared to healthy children, which can...
iSMART: intelligent Social risk Management in AD/ADRD paTients
ABSTRACT People living with dementia (PLWD) from racial-ethnic minoritized groups and socioeconomically disadvantaged environments are more likely to face barriers to diagnosis, ca...
Improving needs among older adults: the ICUconnect 2 primary palliative care RCT
Abstract Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable acros...