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606,025 grants found
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Identifying molecular mechanisms of responding to gravity using the nematode C. elegans
ABSTRACT Impaired ability to respond to the earth’s gravitational field and loss of balance results in high risk of falls with adverse consequences for one’s health, quality of lif...
Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteins
Phospholipase C b (PLCb) enzymes increase intracellular calcium in response to diverse extracellular signals, regulating numerous processes including cell proliferation and surviva...
Utilizing senolytics to enhance the response to exercise in cachectic mice
Project Summary. Skeletal muscle mass and function are key determinants of an individual’s healthspan and are tightly correlated with both physical and metabolic health. In cancer...
Promoting Rigor and Reproducibility in Rodent Models of Metabolic Disease through Thermoneutral Housing
PROJECT SUMMARY Preclinical research relies heavily on appropriate animal models to better understand human biology and to test the safety and efficacy of new therapies. It is impo...
Development of Tetrahydrocannabivarin as a Treatment for Smokers
ABSTRACT Tobacco use is the leading cause of preventable death and disease in the United States. The majority of smokers report the desire to quit smoking; however only 3-5% of una...
Early life pain and its modulation by socioenvironmental factors: Implications for substance misuse
ABSTRACT Roughly 10% of births in the United States are premature and typically involve a stay in the Neonatal Intensive Care Unit (NICU), where infants endure painful procedures a...
Targeting Lung Fibrosis Using Epigenetic Therapy
PROJECT SUMMARY Pulmonary fibrosis is a complex disease that limits lung function through development of collagen-rich scar tissue. Although there are currently two FDA-approved th...
ERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's Disease
ERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's Disease ABSTRACT Alzheimer’s disease (AD) is an age-dependent progressive neurodegenerative disea...
Maternal Fetal Metabolic Disruption in Prenatal Alcohol Exposure
Project Summary Despite public health efforts to reduce prenatal alcohol exposure (PAE), 11.7% of pregnant women in the U.S. consume alcohol and 3.9% binge drink. PAE can lead to g...
The Role of Striatal Astrocytic Dopamine D2 Receptor Signaling in the Pathogenesis of LRRK2-Mediated Parkinson's Disease
Mutations on the LRRK2 gene, which increase the encoded protein's kinase activity, are common genetic causes of familial Parkinson's disease (PD). Noncoding variants at t...
Elucidating the Link Between Oral Health and Dementia Subtypes: A Multifaceted Study on the Biological Pathways and Social Determinants
Project Summary/Abstract As the U.S. population ages, the number of individuals living with dementia is rapidly increasing, making the identification of modifiable risk factors mor...
Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center
The mission of our Wellstone Center is to perform cutting-edge research that leads to transformative therapies for myotonic dystrophy type 1 (DM1) and 2 (DM2). Our Center is based...
Administrative Core
Myotonic dystrophy (dystrophia myotonica, DM) is a dominantly inherited disease that is the most prevalent adult-onset muscular dystrophy. However, congenital DM individuals are th...
Scientific Resource Core
Title: Shared Resource Core Summary/abstract Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) have multisystem complications that are serious, progressive,...
Training and Educational Core
This Wellstone training core is focused on training the next generation of clinical and bench scientists focused on muscular dystrophies, in particular the myotonic dystrophies, wh...
DM2 pathomechansims and therapeutic development
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are dominantly inherited muscular dystrophies caused by short tandem repeat, or microsatellite, expansions in the noncoding regions...
Mechanisms underlying differential efficacy of DM1 therapeutics
The therapeutic landscape for myotonic dystrophy type 1 (DM1) has advanced dramatically in the past 5-years, but conflicting observations about the metabolism of expanded CUG mRNA...
Biological determinants of myotonic dystrophy variability
Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats in exon 15 of DMPK, whereas myotonic dystrophy type 2 (DM2) is caused by expanded CCTG repeats in intron 1 of CNPB...
Vanderbilt Oregon COllaborative Scholar Training in Addiction Research (COSTAR)
PROJECT SUMMARY Substance use and associated HIV, hepatitis C (HCV), and mental health comorbidities continue to drive morbidity and mortality. Interdisciplinary, interinstitutiona...
Clonal Hematopoiesis Aging Resiliency Mechanisms
Project Summary With age, dividing cells acquire DNA mutations. A small number of these somatic mutations confer a selective advantage leading to clonal outgrowth. In blood, this p...