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606,025 grants found
Showing 34,981 – 35,000 of 606,025 grants
Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome Reactivation
Abstract: We previously confirmed that loss of the X-linked gene NEXMIF results in social behavior deficits and intellectual disability.Although only male NEXMIF patients were init...
Age-equivalent neurons from MCI patients to investigate early determinants of AD
SUMMARY Alzheimer's disease (AD) affects over 50 million people worldwide. In the vast majority of patients, AD develops sporadically in the absence of any known etiology othe...
The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)
Parkinson's disease (PD) is an intractable disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra, resulting in tremor, rigidity, bradykine...
Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients
Project Summary/Abstract Allogeneic hematopoietic cell transplantation (HCT) was developed in the 1950’s as a treatment option for life- threatening malignant and non-malignant dis...
Defining TBK1-associated autophagy networks in neurons
Project Summary/Abstract Frontotemporal dementia (FTD) is characterized by the unrelenting loss of cortical neurons that manifests clinically as devastating changes in the behavior...
The cross-talk between a-Synucleinopathies and T cell immunity in ADRD
Project Summary α-Synucleinopathies includes Dementia with Lewy Body (DLB), Parkinson's Disease with Dementia (PDD), and Alzheimer's Disease with Lewy Body Dementia (AD-L...
Patient-Oriented Research for Cardiometabolic Health in Children
PROJECT SUMMARY The goal of this K24 Midcareer Investigator Award in Patient-Oriented Research is to enhance the ability of Dr. Miriam Vos to train, mentor, and support new investi...
Distinguishing α-Synuclein S129 Phosphorylation in Health and Lewy Body Dementia
α-Synuclein (αS) is an abundant brain protein that regulates neurotransmission. αS is also implicated in Parkin- son’s disease (PD), PD with dementia (PDD), dementia with Lewy bodi...
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk Factors
PROJECT SUMMARY Research. Cardio and cerebrovascular risk factors (CVRFs) such as hypertension and diabetes increase the risk of Alzheimer's disease (AD). The prevalence of CV...
TRANSFORM - Transforming the evidence base on estimating prevalence of opioid use disorder and expanded access to interventions to prevent drug related deaths: an international data linkage study
PROJECT ABSTRACT The scale of opioid harms in the US and globally requires urgent action to improve efforts to reduce such harms. Evidence on the number of people with opioid use d...
Electrophysiological and molecular imaging of early AD progression
PROJECT SUMMARY Research on Alzheimer’s disease has strongly focused on pathological alterations such as plaques and tangles, and has overlooked the functional consequences of neur...
Neurobehavioral and Psychosocial Predictors of Health Risk Behaviors in Adolescence and Young Adulthood
PROJECT SUMMARY Young adulthood is a developmental period during which health risk behaviors (HRBs) (e.g., substance use) peak, but the factors that lead to sustained addiction are...
Extracellular matrix in vertebrate hematopoietic stem cell specification
(PLEASE KEEP IN WORD, DO NOT PDF)Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Hematopoietic s...
Rare sperm screening and retrieval with a domain-adaptive deep learning-enabled microwell system.
Project Summary Reproductive challenges are a growing concern worldwide, marked by a 50% decline in fertility rates over the past 50-years. Approximately 10% of couples face infert...
A cross-sectional and longitudinal study of gut microbiota in Parkinson's disease
Project Summary/Abstract The majority of the PD patients have a long history of constipation before the onset of the motor symptoms of PD. Abnormal gut microbiota (dysbiosis) and i...
Discovery of synthetic and endogenous ligands for orphan GPCR GPR156
G Protein coupled Receptors (GPCRs) regulate every aspect of human physiology. However, the endogenous ligands activating ~100 GPCRs are still unknown, hence they are named orphan...
PRICE- Alcohol: Planning the Regional Implementation of a Culturally Adapted Brief Intervention for Alcohol for Tanzanian Emergency Departments
ABSTRACT Alcohol use is rapidly increasing in low- and middle-income countries, where it is inexpensive, readily available, poorly regulated, and there are few resources devoted to...
Pathogenic Role of APP E590D in Alzheimer’s Disease.
Project Summary Our preliminary studies show that the APP E590D variant, identified in two AD patients’ brains, substantially induces more Aβ than APP-WT in vitro cell line and pri...
BRC Modernization of Sterilizing Equipment
Abstract This proposal is to modernize the C.W. Steers Biological Resources Center (BRC) to meet its growing sterilizing needs by purchasing a new efficient sterilizer with a water...
Pairing tVNS with motor skill training in older adults
Summary Motor function is often compromised by neurological injury, such as stroke and even healthy aging. Decline in motor skills reduces the quality of life and independence in a...