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606,025 grants found
Showing 34,941 – 34,960 of 606,025 grants
Adaptive immunity to Aspergillus during neutropenia
PROJECT SUMMARY/ABSTRACT Aspergillus species are ubiquitous molds that cause clinical disease in hosts with impaired immunity or abnormal mucosal defenses. In particular, individua...
Multifaceted Regulation of Mineralocorticoid Receptor Transcriptional Activities
Project Summary Transcription factors (TFs) recognize specific DNA sequences and recruit coregulators including chromatin modification enzymes to direct gene expression. The human...
Elucidating Context-Specific FERONIA Receptor Kinase Signaling
Elucidating Context-Specific FERONIA Receptor Kinase Signaling Project Summary/Abstract Understanding how cellular signaling pathways achieve specificity is an important question i...
Noncanonical roles of Bim in heat shock-induced cell death
PROJECT SUMMARY/ABSTRACT Severe hyperthermia (heatstroke) is due to a failure of thermoregulation that can lead to cell death in various tissues resulting in multisystem organ fail...
IDEAL-XAI: Advancing Explainable AI to Identify Early Driver Events of Alzheimer's Disease
Project Summary Alzheimer’s disease (AD) lacks effective treatment, primarily due to our limited scientific understanding of the early cellular pathways leading to end-stage pathol...
Understanding the relationship between precocious neuronal differentiation and early-onset neurodegeneration
Several common mechanisms have been implicated in neurodegenerative diseases. The accumulation of misfolded proteins, microtubule disruption, mitochondrial dysfunction, upregulatio...
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease
Abstract Diet and nutrition influence our cognitive abilities, how our brains age, and vulnerability to neurodegeneration. However, the interaction of diet with the human brain is...
Hospital delirium in the rapidly aging incarcerated population
PROJECT SUMMARY/ABSTRACT The older incarcerated population in the United States (US) has increased by more than 4,000% since 1981. By 2030, there will be more than 400,000 adults ≥...
Improving Person-Centered Outcomes for Older Adults with Cancer Discharged to Skilled Nursing Facilities and their Family Caregivers
PROJECT SUMMARY/ABSTRACT: Dr. Singh’s long-term goal is to lead research efforts that enhance delivery of palliative care to improve person-centered outcomes for hospitalized older...
Translation of overprinted non-canonical open reading frames from alternative transcript variants
This project describes a class of recently discovered human genes: internal open reading frames (iORFs) that overlap annotated protein coding sequences in alternative reading frame...
Attentional Resilience in Older Adults
In delirium and Alzheimer’s disease (AD), which increase the risk for each other, patients suffer deficits in executive functions, including attentional control. There is a critica...
Interactions between diverse brain cell types drive Aicardi-Goutieres neuropathology
ABSTRACT Aicardi Goutières (AGS) is a severe autoinflammatory disease that predominantly affects the brain, leading to severe cognitive and physical disabilities. Although this dis...
Understanding spatial representations in rat orbitofrontal cortex
Project summaryGrowing evidence suggests that adaptive value representations in the brain are critical to flexible decision making. Inflexibledecisions are a hallmark of a range of...
Microglial Responses to Cell-free DNA in Alzheimer's Disease
Project Summary/Abstract This Mentored Patient-Oriented Research Career Development Award application is for Dr. Lolita Nidadavolu, Assistant Professor of Medicine in the Division...
Individual functional brain mapping for biomarker discovery in Alzheimer's
PROJECT SUMMARY: Alzheimer’s disease (AD) affects over 6 million Americans, and its incidence is projected to double by 2050 due to an aging population. In the fight against AD, th...
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease diagnosed postmortem in people exposed to repetitive head impacts (RHI) from football and other contact sports...
Discovery of novel tau proteoforms as biomarker candidates for AD and PSP
Project Summary Abstract Early detection and diagnosis of Alzheimer’s disease (AD) or Alzheimer’s disease and related dementias (ADRD) have been important goals of the National Pla...
Xylazine exposure and transitions to low-frequency injecting and injection cessation
Project Summary: We propose a two-year qualitative study that will characterize transitions to low-frequency injecting and injection cessation among people using xylazine-adulterat...
Deciphering the immunogenicity of cell death using systematic genetic tools
Project Summary Professional phagocytes, including macrophages and dendritic cells, engulf approximately 200 billion dead cells per day in humans. The vast majority of dead cells a...
Exploiting the microbiota-stromal cell axis for microbiota-targeted medicine
PROJECT SUMMARY The development of successful vaccines is a significant achievement in public health. However, vaccines exhibit varying efficacy across different individuals and po...