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606,025 grants found
Showing 34,921 – 34,940 of 606,025 grants
Evaluating real-world effectiveness of tele-buprenorphine: A mixed-methods study to develop clinical guidance
Project Summary/Abstract Buprenorphine is a life-saving treatment for people with opioid use disorder (OUD), yet only 1 in 5 people with OUD receive this medication. Telehealth-del...
Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA Metabolism
Abstract Propionic acidemia (PA) is a rare metabolic disease due to PCCA or PCCB mutations. PA could develop various complications even with dietary restriction. While gene therapy...
Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis
PROJECT SUMMRAY Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier breach, resulting in harmless antigens penetrating t...
Mechanisms of hypoxia-mediated memory impairment in an animal model of acute respiratory failure in preterm survivors
Summary Due to advances in neonatal care, most preterm infants no longer develop cerebral palsy from hypoxic-ischemic white matter injury (WMI). However, up to 50% develop gray mat...
The Role of the Complement Pathway in Alzheimer's Disease
Abstract The development of -amyloid (A) pathology in Alzheimer’s disease (AD) is accompanied by hyperactivation of microglia and neuroinflammation. Genome-wide association studi...
Transmembrane Protein 178 as a Novel Endogenous Inhibitory Mechanism in Asthma
PROJECT SUMMARY Asthma is characterized by chronic, non-resolving lung inflammation; however, there are endogenous inhibitory mechanisms that normally promote the resolution of lun...
BMT Core - Pediatric Transplantation and Cellular Therapy Consortium (PTCTC): Providing Clinical Trial Access For Children With Life Threatening Diseases
Abstract: Allogeneic hematopoietic cell transplantation (HCT) is uniquely curative for a variety of pediatric malignant and non-malignant conditions. With respect to non-malignant...
Identifying optimal dietary patterns for postpartum cardiovascular disease prevention
PROJECT SUMMARY Cardiovascular disease has declined dramatically in all US adults except young women, whose rates remain stagnant. Young women who are Black or low-income carry the...
Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma
PROJECT SUMMARY Treatment with immune checkpoint inhibitors (ICI) has been revolutionary in melanoma and other cancers. However, only a subset of patients will have durable respons...
An Automated Frailty Scoring System for Lung Transplantation Based on Bio-Geo-Composition
Abstract: Lung transplantation is a life-saving treatment for individuals suffering from end-stage lung diseases. The number of lung transplants is increasing annually, and over 50...
Developing an Ontology for Dental Care-Related Fear and Anxiety: Toward an Understanding of Problems in Dental Care Utilization
Project Summary/Abstract Dental care-related fear, anxiety, and/or phobia (hereafter, DFA) traditionally refers to the emotional, behavioral, and/or physical responses that may occ...
Dynamics of RNA regulation and noncanonical translation between cell states
Project Summary The genetic landscape of patient samples has illustrated a vast array of potential diagnostic and clinical biomarkers through profiling of chromosomal rearrangement...
BMT Core: Southeast Bone Marrow Transplant Consortium
PROJECT SUMMARY/ABSTRACT The SE-BMT Consortium, formerly the UF Consortium, has expanded its network to include the University of Alabama at Birmingham (UAB). This extended collabo...
Addressing the Impacts of Structural Racism on Race Inequities in Health: A Focus on Mass Incarceration, Housing, and their Intersection
This multi-level mixed methods study will analyze the implications for racial health equity of policies that undergird structural racism (SR) in the domains of mass incarceration (...
Write From The Start
ABSTRACT Peer-reviewed publications are essential for successful careers in biomedical research. The development of strong writing skills is critical for early stage investigators...
Defining HIV evolution at the innate immune interface
PROJECT SUMMARY HIV remains a major global health burden, in large part because of its massive evolutionary potential to rapidly evolve escape mutations even from multi-drug therap...
Cell-Type Selective Transcriptional and Mitochondrial Control of Drug Seeking
Substance use disorders comprise chronic cycles of drug use, abstinence, and relapse driven by drug-induced transcriptional and circuit adaptations in the brain. Despite consistent...
Tablet-Based Physical Activity Intervention for Frail and Pre-Frail Older Adults with Systemic Lupus Erythematosus
PROJECT SUMMARY: Although adults with systemic lupus erythematosus (SLE) now live routinely to 50-years of age and beyond, their risk for adverse health outcomes is higher compared...
Sleep Health and Cognitive Function among Middle-aged Adults: the SleepCog Study
PROJECT SUMMARY/ABSTRACT Dr. Minjee Kim is a practicing neurologist with expertise in sleep research and clinical assessment of cognitive impairment (CI). Her long-term goal is to...
Addressing Racial Disparities in Chronic Lung Disease for Preterm Infants Through Parent Engagement
PROJECT SUMMARY/ABSTRACT Every year, 50,000 preterm infants are diagnosed with chronic lung disease (CLD). CLD is associated with reduced lung function and morbidity that persists...