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606,025 grants found
Showing 34,901 – 34,920 of 606,025 grants
Integrating low-cost and versatile technologies to achieve colorimetric HCV and HIV detection from whole blood
PROJECT ABSTRACT In the United States alone, over 2 million people live with active hepatitis C virus (HCV) infections, and up to 140,000 new infections occur each year. Since 2013...
Brain Connectomics of Cognitive Aging and Vulnerability to Alzheimer's Disease
PROJECT SUMMARY The goal of this career development award is to provide me with the training necessary to develop an independent aging research program focusing on neuroimaging bio...
Brain and Behavioral Mechanisms Linking Loneliness and Social Isolation with Accelerated Cognitive Aging and Alzheimer's Disease and Related Dementias
Brain and Behavioral Mechanisms Linking Loneliness and Social Isolation with Accelerated Cognitive Aging and Alzheimer’s Disease and Related Dementias Loneliness and social isolati...
The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)
PROJECT SUMMARY / ABSTRACT Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease of aging that usually leads to death within 5-7-years of diagnosis. There are...
Examining the Association between Residential Ambient Air Pollution and Pediatric Hospitalization due to Acute Respiratory Disease Across New York State
Project Summary Ambient air pollution is a major pediatric public health concern due to its ubiquity and increased exposure patternsaffiliated with climate change over the next dec...
Electronically Delivered Home Rehabilitation to Improve Symptoms and Activity After Pulmonary Embolism
This proposed Mentored Patient-Oriented Research Career Development Award will support Dr. Lachant’s advancement as a physician-scientist equipped to conduct independent research w...
Elucidating the impact of immune imprinting on SARS-CoV-2 variant vaccination strategies using a humanized mouse model
PROJECT SUMMARY / ABSTRACT: Rationale: Continued evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to immune-evasive variants that pose a persistent...
Understanding protein turnover alterations in physiological brain aging
Understanding protein turnover alterations in physiological brain aging ABSTRACT In mammals, physiological aging is associated with multiple molecular changes that lead to loss of...
Molecular mechanisms of pathological aging of human brain and adipose and their inter-organ communication
Project Summary Advanced age is a major risk factor for age-related diseases such as type 2 diabetes (T2D), Alzheimer’s disease (AD) and many others. It remains elusive what aging...
The Impact of the COVID19 Pandemic on the Hispanic/Latinx Birth Outcome Advantage
Project Summary This project focuses on whether the COVID-19 pandemic has put the well-established Hispanic infant health advantage in peril. The U.S. Hispanic population has been...
Serotonin Modulation of Neural Circuitry in bvFTD: Understanding the Neurobiology of Mood and Cognitive Symptoms
Dementia is a leading cause of disability and death worldwide, with the most significant impact on those with young-onset dementia. Frontotemporal dementia (FTD) is the most common...
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
The nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe, lethal hemorrhagic disease. CCHFV is the most prevalent tickborne virus that causes human disease and is...
The lysosomal fasting response in intestinal stem cells and cancer
PROJECT SUMMARY Fasting improves organismal health and tissue homeostasis in part by enhancing stem cell activity. In addition, stem cells serve as a cell-of-origin in multiple can...
The Impact of the Accountable Care Organization Realizing Equity, Access, and Community Health (ACO REACH) Program on Outcomes and Equity for Patients with Alzheimer's Disease and Related Dementias
ABSTRACT Health inequities in older adults along racial and sociodemographic lines are persistent and pervasive in the United States. These inequities are particularly profound amo...
Identifying tandem repeat expansion-mediated mechanisms of autism-risk genes
Project Summary Autism spectrum disorder (ASD) is a set of neurodevelopmental conditions that affect communication and social interactions with restricted interests and repetitive...
Realizing BRAVE-EM for Nanoscale Multicolor Imaging in Biology: Biological Real-space Absorption Visualization by photoEmission Electron Microscopy
Project Summary/Abstract Imaging cells and tissue labeled with fluorescent molecules and proteins is critical in biological research, enabling visualization of the locations of spe...
Decoding endocrine and paracrine communication through mammokines
Project Summary Interactions among different organs are pivotal in developing pathological conditions like obesity and type 2 diabetes. Substantial research efforts have been direc...
Reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitis
Project Summary/Abstract Necrotizing enterocolitis (NEC) is a severe, often fatal intestinal disease of prematurity. Mortality rates approach 50% if surgery is required to resect n...
Piloting a patient navigator program to facilitate uptake and persistence with evidence-based weight loss interventions
Abstract Millions of adults in the U.S. with overweight or obesity would like to improve their health and quality of life via weight loss, yet utilization of evidence-based weight...
Memory in the enteric nervous system
Project summary The formation of memories is central to the human condition. It enables learning and the accumulation of knowledge overthe lifespan, and it allows using the past in...