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606,025 grants found
Showing 34,161 – 34,180 of 606,025 grants
REST-MED12 Pathways in the Regulation of Estrogen - Progesterone Sensitivity in Uterine Leiomyoma
Project Summary/Abstract Uterine fibroids (leiomyomas) are benign smooth muscle cell (SMC) tumors of the myometrium. Leiomyomas represent the most frequent clinical indication for...
Mechanisms for environmental microplastics-enhanced colorectal tumor progression
Project Summary In response to the Notice of Special Interest (NOSI) NOT-ES-23-002, our research addresses the urgent concern of escalating plastic pollution. Despite numerous repo...
Biomarker Assessment of Adherence and Effectiveness in a Randomized Controlled Trial to Reduce Added Sugar Intake in Adolescents
PROJECT ABSTRACT Added sugar (AS) is a critically important dietary target for intervention in adolescents; it contains excess calories with no nutritional value and is independent...
Role of Long Non-coding RNAs in the Ovulatory Process
TITLE: Role of Long non-coding RNAs in the Ovulatory Process. ABSTRACT Women’s reproductive health plays a pivotal role in regulating overall well-being. Unfortunately, about 12% o...
Regulating Establishment of the Mammalian Ovarian Reserve
Project Summary Approximately 12% of couples are infertile and 1% of the female population worldwide experiences primary ovarian insufficiency (POI) which results from a reduction...
From Perceptions to Behaviors: A Comprehensive Approach to Examine the Impact of Public Health Communication Messaging about the Continuum of Risk for Tobacco Products
PROJECT SUMMARY Effective communication strategies are urgently needed to convey the relative risks of tobacco products accurately among adults who currently use combustible tobacc...
Membrane Ubiquitin Ligase-Driven Immune Evasion in HPV+ Head and Neck Cancer
PROJECT SUMMARY Human papillomavirus (HPV) is the causative agent of 5% of all human cancers, including 25% of head and neck squamous cell carcinomas (HNSCCs). HPV-driven disease p...
Prevention of Chlamydia trachomatis infections: Evaluation of vaccination and post-exposure prophylactic antibiotic use as population-level strategies
PROJECT SUMMARY The global burden of sexually transmitted infections has increased over the last several decades. In 2020 alone, the World Health Organization estimated that 128.5...
Patient Dumping and EMTALA Enforcement Involving Psychiatric Emergencies
Project Summary Psychiatric emergencies comprise a large and increasing proportion of emergency department (ED) visits, with many psychiatric patients receiving suboptimal care whi...
Discovery of new phage defense systems in Vibrio cholerae
Abstract: Over a century ago, Felix d’ Herelle began using bacterial viruses which he termed “bacteriophages” to treat bacterial infections. Such “phage therapy” has gained new int...
Development and application of whole-body patient-specific computational mesh phantoms for organ dosimetry and second primary cancer risk quantification following external beam radiotherapy
PROJECT SUMMARY Approximately half of all cancer patients in the United States are treated with external beam radiotherapy (RT), with approximately 40% of all curative treatment be...
Exploring the role of C. albicans oxidative stress pathways in S. mutans reactive oxygen species tolerance
Abstract Dental caries is the most prevalent chronic infectious disease, affecting an estimated 2.5 billion people worldwide. Streptococcus mutans is an important pathogen in denta...
Endogenous drivers of endothelial inflammation in Alzheimer's Disease
PROJECT SUMMARY Senescent cells (SnCs) accumulate in tissues with increased organismal age. SnCs have been associated with multiple age-associated chronic diseases and implicated a...
Advancing a biopsychosocial model of bedtime procrastination
PROJECT SUMMARY Cardiometabolic diseases are the leading cause of death in the United States. With rates of these diseases rising, there is an urgent need to identify modifiable ri...
The Role of PICALM in Regulating Neurogenesis in Alzheimer's Disease
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Ninety five percent of AD cases are sporadic late onset (LOAD) of unknown cause. Aging is the greatest risk...
Improving engineered TCR-T cell therapy for solid tumors by targeting Tcf1+ stem-like reservoirs in tumor-draining lymph nodes
PROJECT SUMMARY Adoptive transfer of engineered T cells targeting tumor antigens is ineffective against most solid tumors, due in-part to poor persistence and the rapid onset of dy...
Mechanism, connectivity, and outcome prediction of anxiety intervention from MRI-derived models in tDCS augmented cognitive training
Project Summary / Abstract Alzheimer’s disease (AD) is the most common form of dementia. The rate of dementia increases almost exponentially with age – thus, the prevalence of AD h...
Enzyme-Mediated Depletion of Extracellular Adenosine and 5'methylthioadenosine as a Novel Anti-Cancer Therapeutic
PROJECT SUMMARY In recent years, adenosine has been identified as an important therapeutic target due to its observed immunosuppressive effects in the tumor microenvironment. By ag...
Role of FOXK subfamily in KSHV infection
Project Summary Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus with a biphasic lifecycle associated with several diseases such as Kaposi'...
The Left and Right Ventricles in Sleep Apnea with COPD
Abstract Dr. Janna Raphelson is a Pulmonary Critical Care fellow at UCSD and she is applying for this F32 grant to further her development as an academic physician scientist. Throu...