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606,025 grants found
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DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: RECRUITMENT AND FOLLOW-UP OF SECOND SUBCOHORT OF PREGNANT WOMEN AND THEIR PARTNERS
Health disparities in the United States have their origins as early as the prenatal period. Early life conditions including poverty and discrimination generate disparities in healt...
Mechanisms of Replication Stress Tolerance in SCLC
PROJECT 2 SUMMARY Exacerbating replication stress is a powerful means to kill cancer cells through mitotic catastrophe due to intolerable levels of DNA replication-associated lesio...
Repair Mechanisms of Replication fork Lesions in SCLC
PROJECT SUMMARY This project will investigate the specific mechanisms of DNA lesions that are generated in SCLC during treatment and lead to response or resistance to therapy. This...
Impact of recurrent genetic alterations on SCLC subtypes and therapeutic response
Project Summary Small cell lung cancer (SCLC) is a highly aggressive malignancy with high heterogeneity and few available treatment options. SCLC cells are of highly plastic enabli...
SCLC Model Generation and Therapeutic Analysis
Project Summary The laboratory mouse plays a central role in the preclinical development of new therapeutic strategies and through the application of transgenic technology has prov...
Advanced Imaging and Computational Approaches
The Advanced Microscopy and Computational Approaches Core (Core C) will provide advanced imaging and computational approaches to support this Program Project in elucidating the mol...
Unmasking neuromodulatory control of locomotion
Project Summary Neuromodulators including dopamine and serotonin have profound effects on spinal circuits for locomotion. A wealth of pharmacological manipulations has shown that d...
Hydroxyproline Dehydrogenase Inhibitors for the Treatment of Primary Hyperoxaluria
PROJECT SUMMARY: The breakdown of hydroxyproline, a component of collagen within our bodies and in the meat that we consume, is a significant contributor to glyoxylate and oxalate...
Neural Mechanisms of Social Information Processing
Project Summary To feel, remember and act in a social environment, incoming social stimuli must be processed and represented. Recent advances have revealed several routes of social...
Developing strategies for using DNA data to assist family reunifications across child development stages
PROJECT SUMMARY Family separations due to disasters, armed conflict, and migration affect millions, are expected to increase, and damage children’s health across the lifecourse. Gi...
Wirelessly recording and manipulating neural activity to study the sensorimotor dynamics of free behavior
In our daily lives, we explore and learn about the world around us through body movement. For instance, to find your keys in your bag, you use your fingers to touch each object in...
Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delays.
Abstract Neuroimaging of infants and young children is increasingly used to monitor brain development that can ultimately influence long-term health and behavioral outcomes. Our re...
JiHi, An Artificial Intelligent HAZWOPER e-trainer for tutoring and evaluating emergency first response clinical skill proficiency.
PROJECT SUMMARY HAZWOPER emergency response work represents one of the most dangerous jobs in the United States (U.S.) where, in many cases, emergency medical first responders are...
Understanding the role of bedrock, settlement patterns, and water quality in human health equity
Project Summary Neither populations nor health outcomes are spread evenly across the natural environment. Due to historical patterns of selective land settlement, natural resource...
Associations Between Adversity and Psychological Distress and Physiological Stress Among Youth Experiencing Homelessness: The Buffering Role of Social Network Processes
Project Summary/Abstract Youth experiencing homelessness (YEH) face increased levels of adversity and higher rates of trauma, suicide, and mortality compared to their housed peers....
Modulating the Stem Cell Niche Set Point to Improve Skeletal Muscle Regeneration
Abstract Human pluripotent stem cells (hPSCs) transplantation therapies offer an appealing avenue to combat skeletal muscle diseases. Directed differentiation of hPSCs to skeletal...
Intravesical genome editing in urothelium
This proposal is submitted in response to PAR-23-119: “Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)”. Th...
Molecular determinants of oxidative stress in Salmonella pathogenesis
ABSTRACT: Almost two billion people worldwide become ill with diarrhea annually, and ~700,000 die. Nontyphoidal Salmonella, such as Typhimurium, cause roughly 180 million diarrheal...
Evaluation of Bioenergetic Supplements in Treatment-Resistant Depression, Cognitive Dysfunction and Anxiety
Major depressive disorder (MDD) and anxiety are linked to brain deficits in the bioenergetic molecules creatine (CR) and acetyl-L carnitine (ALC), nutritional supplements which sho...
Four Events Within EVN Media Festival 2025
TO FUND THE ORGANIZATION AND CONDUCT OF FOUR EVENTS WITHIN EVN MEDIA FESTIVAL 2025 PROGRAM.