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606,025 grants found
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Cortical and subcortical dynamics in the central auditory system across learning and overtraining
PROJECT SUMMARY As animals interact with their environment, they build and accrue sound associations with behaviorally relevant outcomes. The mammalian auditory system can be modif...
Identifying neuronal targets and mechanisms of manganese-induced neuromotor disease
Project Summary/Abstract: Manganese (Mn) is an essential micronutrient, but in excess, it is neurotoxic. Humans who are over-exposed to Mn environmentally or occupationally develop...
Defining the role of NUDT5 in ovarian cancer
Ovarian cancer patients are burdened with a lack of effective therapeutic options resulting in a low survival rate due to chemotherapy resistance, recurrence, and metastasis. The o...
The Society of Heart and Vascular Metabolism (SHVM) 21st annual session: Interorgan Crosstalk in Heart and Vascular Metabolism
The goal of the Society for Heart and Vascular Metabolism (SHVM) conference is to bring together scientists and trainees from around the globe to present and discuss cutting-edge r...
Establishing a Useful and Usable "Out of the Box" Quality Improvement Library for Enhanced Health System Efficiency and Outcomes
Project Abstract Phrase Health is a clinical decision support (CDS) analytics company that empowers health systems to efficiently incorporate scientific knowledge into high value c...
Disparities in Risk of Dementia among People Living with HIV using Real-World Data
Project Abstract 1.2M people are living with HIV (PWH) in the US. With advances in antiretroviral therapy, the survival of PWH has increased; half of PWH are over the age of 50. Gi...
PHARMACOKINETICS AND PHARMACOGENOMICS OF DOLUTEGRAVIR-BASED ANTIRETROVIRAL THERAPY IN YOUNG PEOPLE LIVING WITH HIV IN GHANA (PHARMA-YOUNG-HIV)
PROJECT SUMMARY The World Health Organization (WHO) in 2019 recommended dolutegravir (DTG)-based antiretroviral therapy (ART) as the preferred treatment regimen for all persons liv...
Liposomal Amphotericin B and Flucytosine Antifungal Strategies for Talaromycosis (LAmB-FAST)
ABSTRACT Talaromycosis is caused by the dimorphic fungus Talaromyces marneffei (Tm) endemic in Southeast Asia where it is a leading the cause of death among patients with advanced...
Assessing Internalized Health-Related Stigma in Spanish-Speaking Latino Adults
PROJECT SUMMARY/ABSTRACT Stigma adversely affects mental and physical health. Societal devaluation or mistreatment from others can lead to internalization of stigma (i.e., self-sti...
Sources and Self-Management of Chronic Stress in People with Aphasia
PROJECT SUMMARY/ABSTRACT Aphasia is commonly operationalized as a linguistic impairment affecting expressive or receptive language. People with aphasia (PWA) often experience profo...
Developing a Structurally-Motivated Model of Coronary Microcirculation Mechanics and Hemodynamics
Project Summary The myocardium relies on a continuous supply of oxygen from a complex system of blood vessels that make up the coronary circulation. Despite its importance, the cor...
HIV Vaccine Trials Network Laboratory Center - B-Cell and Molecular Assay Multi-year Supplement
Abstract Accelerating B Cell and Antibody Molecular, Functional and Structural Analysis in Sequential bnAb-inducing Env Immunogen Clinical Trials Development of an effective HIV va...
Regulation of mycobacterial adaptive mistranslation
PROJECT SUMMARY Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) uses regulation of specific translation error rates – mistranslation – to survive a varie...
Novel, Self-Applied MicroArray Patch (MAP) of Zanamivir for Treatment of the Flu
Abstract Yearly influenza epidemics strike millions of people, causing up to 500,000 deaths. Fatality caused by most seasonal influenza viruses is
Functional significance of plasma cell infiltrates of human cardiac allograft vasculopathy
PROJECT SUMMARY Cardiac allograft vasculopathy (CAV) is presently the leading cause of morbidity and mortality following heart transplantation. While the pathophysiology of CAV is...
Antibody recognition of paramyxovirus surface proteins
While vaccines are available for SARS-CoV-2, influenza virus, and RSV, and our laboratory has advanced mAbs and vaccines for hMPV, there has been a lack of research on parainfluenz...
Neural Circuits for Stress-Impaired Extinction Learning
PROJECT SUMMARY Clinical disorders of fear and anxiety, including trauma- and stressor-related disorders, represent an enormous public health burden. Unfortunately, cognitive-behav...
Neural Substrates of Contextual Memory in Fear Extinction
PROJECT SUMMARY Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders. Extinction is a fundamental form of learning that...
Maternal Stress, Human Milk Composition, and Neurodevelopmental and Feeding Outcomes
PROJECT SUMMARY/ABSTRACT Preterm birth and the hospitalization of infants in the neonatal intensive care unit (NICU) are well-documented as stressful events for mothers. Although m...
Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome
PROJECT SUMMARY The human oral microbiome is home to a unique group of bacteria with the ability to affect the overall health of the human host: Streptococci spp. This group is inv...