Browse All Grants
606,025 grants found
Showing 34,121 – 34,140 of 606,025 grants
Clinical, Histological, and Transcriptional Associations Between the Diabetic Placenta and Fetal Congenital Heart Defects
PROJECT SUMMARY/ABSTRACT The primary goal of this proposal is to provide a framework of methodologically-diverse, and clinically-inclined, investigative training that will prepare...
Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years
The 548,000 Americans who rely on dialysis to stave off death from kidney failure suffer from malnutrition, inflammation, immune defects, and vastly increased incidence of coronary...
GLP-1R agonist immune targets in lean and obesity-associated asthma
Project Summary Multiple preclinical and clinical studies show that glucagon-like peptide-1 receptor (GLP-1R) agonists, FDA approved agents used in type 2 diabetes, obesity, and ca...
Unraveling the molecular link between heavy metal exposure and triple negative breast cancer
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that lacks targeted therapies. Individuals with Breast Cancer 1 (BRCA1) gene mutations have a significan...
Long-read genome sequencing for the discovery of highly penetrant variation in rare diseases
Project Summary/Abstract The goal of this proposal is to improve upon current methods to identify genetic contributors to rare diseases, especially neurodevelopmental disorders (ND...
Investigating the Structure and Regulation of PFK
PROJECT SUMMARY Phosphofructokinase (PFK) is an essential node governing the flux of glucose through glycolysis. It catalyzes the rate limiting step of glycolysis, converting fruct...
The role of the microbiome and other host related factors in determining urine oxalate levels
Oxalate is involved in the pathophysiology of kidney stones (KS) and chronic kidney disease (CKD), which, respectively, affect more than 9% and 15% of the adult US population. High...
Network mechanisms underlying core behavioral features in Fragile X Syndrome
Project Summary Fragile X Syndrome (FXS), a rare monogenic neurodevelopmental disorder caused by a trinucleotide expansion of the Fmr1 gene on the X chromosome. FXS is the most com...
Plasminogen Activator Pathway in Lymphatic Malformations
PROJECT SUMMARY The lymphatic system is a unidirectional vasculature that absorbs interstitial fluid in the lymphatic capillaries to transfer the lymph fluid through the collecting...
CNS Senescence and Immunopathology in Lethal POWV Infection of Aged Mice
Powassan virus (POWV) is a neurovirulent tick-borne flavivirus (FV) emerging in the N.E. US. POWV causes a 10% fatal encephalitis resulting in severe long-term neurologic damage in...
Meningeal Immunity and Viral Neuropathogenesis
SUMMARY Emerging and re-emerging neurotropic viruses, including flaviviruses and alphaviruses, generally cause fever, malaise, and related symptoms. However, in some patients, thes...
Client and clinician priorities for same-day PrEP and DoxyPEP awareness, uptake, and persistence in primary care.
PROJECT SUMMARY/ABSTRACT Approximately 70% of all new human immunodeficiency virus (HIV) infections are among populations of sexual and gender minorities (SGM) and are primarily at...
Effects of Targeting Immune Activation and Intestinal Barrier on Comorbidities in People with HIV
Project Summary/Abstract People living with HIV infection have increased risk of comorbidities including cardiovascular disease, obesity and diabetes mellitus, despite effective an...
The Mass Partnership for Community-Engaged Cancer Control Equity
ABSTRACT The Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE) builds on a robust partnership between the Harvard T.H. Chan School of Public Healt...
Admin-Core
SUMMARY - ADMINISTRATIVE CORE The Administrative Core of the Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE is designed to provide scientific an...
Research Measures Method and Data Management Core
SUMMARY – RESEARCH METHODS, MEASURES, AND DATA MANAGEMENT CORE The Research Methods, Measures, and Data Management (RMMDM) Core of the proposed Massachusetts Partnership for Commun...
Social Determinants of Health Research Project
SUMMARY– THE COMMUNITY GATEWAY TO HEALTH EQUITY STUDY (SDOH STUDY) The Community Gateway to Health Equity Study, our SDOH study, aims to investigate the impact of a multi-level app...
Community Responsive Project
SUMMARY – COMMUNITY RESPONSIVE PROJECTS PROGRAM Although academics are well-meaning in designing studies they believe will improve health equity, they often do not have relevant li...
Jointly modeling the effects of evolutionary processes on genomic variation
PROJECT SUMMARY Understanding what shapes patterns of genetic diversity in natural populations is an inherently challenging problem. Despite the challenges, studying variation in D...
Cell Based Immunomodulation to Suppress Lung Inflammation and Promote Repair
Acute respiratory distress syndrome (ARDS) affects over 300,000 Americans annually with a 43% mortality rate. Inflammation plays a key pathogenic role in mortality, particularly in...