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606,025 grants found
Showing 33,841 – 33,860 of 606,025 grants
Essential functions of the mitochondrion in malaria parasites
PROJECT SUMMARY Malaria is a devastating disease that impacts millions of people on an annual basis. While several species of Plasmodium parasites cause malaria in humans, P. falci...
The Roles of Parental Mental Health and Help-Seeking: Utilizing a Family Systems Approach to Upstream Suicide Prevention for Sexual Minority Youth
Project Summary Before leaving high school, approximately 1 in 4 sexual minority adolescents will attempt to end their own life; a rate that is nearly four times higher than their...
Platinum Based Countermeasures and Combinations with Protective Agents
ABSTRACT This project's primary endpoint focus will be efficiently rescuing toxic cyanide exposure using three distinct animal models. None of the current countermeasure optio...
Clinical Trials Methodology Course in Neurological Disorders
PROJECT SUMMARY Neurological diseases comprise an extraordinary burden on patients, caregivers, and the healthcare system; the cumulative direct costs are $993 billion/year. Progre...
Ultra-high precision image-guided incisionless transcranial ultrasound surgery
PROJECT SUMMARY Each year, nearly 2 million Americans receive a cancer diagnosis, with surgical removal being the primary treatment approach for solid tumors. Nowhere are the chall...
Unraveling the Mechanisms of Alcohol-Induced Blood-Brain Barrier Disruption: A Focus on Lysophosphatidic Acid Signaling and Endothelial Cells.
Alcohol consumption is a major risk factor for cerebrovascular complications and neuroinflammation, yet the underlying mechanism of alcohol-induced cerebrovascular damage remains u...
Time sensitive research on barriers to pregnancy care
Recent and seismic policy shifts in the Midwest of the United States have abruptly restricted access to abortion and other pregnancy-related care for millions of people. Following...
Pre-Analytic Factors affecting Molecular tests for Congenital Syphilis
PROJECT SUMMARY Syphilis, caused by Treponema pallidum spp pallidum (T. pallidum), cases are rising at an alarming rate with devastating consequences for pregnant individuals and n...
Video Disease Activity Index: A novel video measure to monitor rheumatoid arthritis in telehealth
Title Video Disease Activity Index: a video measure to monitor rheumatoid arthritis in telemedicine Project Summary/Abstract Rheumatoid arthritis (RA) is a degenerative autoimmune...
A novel model of severe inflammatory arthritis induced by pulmonary silica exposure
Occupational silica exposure is linked with systemic autoimmune diseases including rheumatoid arthritis (RA) systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and anti-...
Delivery of apoptotic neutrophils to improve angiogenesis during wound healing
PROJECT SUMMARY/ABSTRACT Every year, millions of patients suffer from impaired wound healing due to injuries, surgeries, and diseases, creating a significant public health and econ...
Molecular and cellular mechanisms of visceral pain and cross-organ sensitization
PROJECT SUMMARY/ABSTRACT Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disorder characterized clinically by recurring episodes of pelvic pain and increased urin...
Neural Circuit Effects of Chronic Alcohol
Project Summary Chronic alcohol use has long-lasting detrimental effects on human cognition and behavior that result from changes in brain function. Here we examine changes in cort...
Advancing Perinatal Health Equity through a Community-engaged Model of Healthcare Services
PROJECT SUMMARY In the US, disparities between non-Hispanic Black and White patients in pregnancy-related outcomes, including perinatal depression symptomology, are stark and perva...
Engineering for Women's Health
The Engineering for Women’s Health Conference addresses historical disparities in women’s health research by establishing a dedicated platform for interdisciplinary collaboration a...
Evaluating a Novel Enzymatic Modality for the Treatment of Fanconi Anemia
Project Summary Fanconi anemia is an inherited illness caused by faulty Fanconi Pathway genes responsible for repairing DNA damage. It is estimated to afflict 1 in every 100,000-16...
Exploiting glycan holes and sequence diversity of naturally occurring HIV envelope towards the design of vaccine immunogen panels for induction of neutralization breadth
PROJECT SUMMARY/ABSTRACT Vaccine-mediated protection against viral pathogens frequently depends on neutralizing antibodies. However, the HIV-1 envelope (Env) glycoprotein gp120 is...
Mechanisms of mitochondrial dynamics, quality control and mtDNA-mediated inflammation in alcohol-associated liver disease
Project Summary/Abstract Despite recent progress on understanding the mechanisms of alcohol-associated liver disease (ALD), no successful treatment for ALD is available. Alcohol me...
Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing
ABSTRACT Pregnancy is a unique, early moment of cardiovascular stress in young women that may “unmask” cardiovascular disease (CVD) propensity. Preeclampsia (PreE)—characterized by...
The Re-Engineered Discharge for Diabetes Care Transitions (REDDCAT2): Screening and Addressing SDOH Needs at Hospital Discharge
REDDCAT2 Project Abstract Summary Over 36 million Americans are diagnosed with type 2 diabetes mellitus (T2DM), accounting for more than 7.8 million hospital admissions and $327 bi...