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Cell-penetrating botulinum proteases as topical therapeutics
ABSTRACT The importance of communications between nerve cells and immune cells in skin has been increasingly recognized, as are the contributions of sensory neurons and the neurope...
Adipocytes and inflammation in the cutaneous leishmaniasis outcome
Summary Leishmania braziliensis infection may cause a high spectrum of clinical manifestation, including the more prevalent form, cutaneous leishmaniasis (CL). Inflammatory respons...
Novel Lassa fever live-attenuated vaccine platform with safety features ensuring unbreachable attenuation
Project Summary/Abstract The mammarenavirus Lassa (LASV) is endemic to West Africa where it infects several hundred thousand individuals yearly resulting in a high number of Lassa...
Translational Control of Host Environmental Stress Responses in Candida albicans
PROJECT SUMMARY/ABSTRACT Candida albicans is a major human fungal pathogen responsible for a wide variety of systemic and mucosal infections. Immunocompromised individuals, includi...
Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)
The primary goal of this proposal is to hasten therapeutic development by validating outcomes and refining clinical trial strategies for pediatric-onset FSHD. Cross sectional studi...
Diabetic Targeted Dual Neuromodulation Parametric Optimization
Project Summary/Abstract 31 million Americans suffer from Type 2 Diabetes Mellitus (T2DM) with numbers growing in the elderly and children. Also, 84.1 million prediabetic Americans...
Mechanisms and means to improve HIV bnAb activity in vivo
ABSTRACT A number of anti-HIV-1 broadly neutralizing antibodies (bNAbs) targeting highly conserved and vulnerable epitope regions of the envelope glycoprotein (Env) are being inves...
Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitis
Abstract Globally, central nervous system (CNS) infections have one of the largest burdens of death and disability, particularly among persons with weaken immune systems due to the...
Emotional Granularity and Interoceptive Accuracy: Affective Skills Linking Dimensions of Childhood Adversity with Adolescent Stress Vulnerability
PROJECT SUMMARY Childhood adversity is common and increases risk for multiple forms of psychopathology emerging in adolescence. Heightened sensitivity to stress is one pathway thro...
Reaching New Heights: Strengthening Health Professions Research at a Majority Hispanic-Serving Institution
Project Summary Although health professions (allied health, nursing, social work, clinical psychology) represent more than 80% of the healthcare workforce, rigorous research within...
The Future of Rural Health: Accelerating Biomedical Excellence at TTUHSC
Abstract: This NIH STRONG-RLI proposal submitted in response to PAR-23-144 is entitled The Future of Rural Health: Accelerating Biomedical Excellence at Texas Tech University Healt...
CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis
SUMMARY Hepatic stellate cells participate in liver wound healing but also in progression of liver fibrosis and promotion of liver cancer. Heterogeneous subsets of activated HSC (a...
Adolescents' Social Media Use and Internalizing Symptoms: Mechanisms of Risk and Resilience
Project Summary/Abstract Rates of internalizing symptoms (depression, anxiety) among youth have increased significantly over the past decade. During this same time period, the use...
Optimizing Smart Digital Therapeutic Message Components for Engagement and Clinical Outcomes for Alcohol Use Disorder
Project Summary Clinician-delivered relapse prevention interventions for alcohol use disorder (AUD) are effective when delivered but the vast majority of adults with an active AUD...
Elucidating Roles of Distinct Spinal Cord Cell types in Mediating Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)
Abstract Interstitial cystitis/bladder pain syndromes (IC/BPS) are a debilitating painful condition with unknown etiology. The cells and the circuits in the spinal cord that proces...
Closing the Adolescent and Young Adult Clinical Trial Enrollment Gap with an AYA (Alert, Young Adult Navigation and Alliance) Clinical Tool
Project Summary More than 80,000 adolescents and young adults (AYAs, ages 15- 39-years) are diagnosed annually with cancer in the United States, but relatively few enroll on cancer...
Antimicrobial Blue Light Emitting Envelope for the Control of Cardiac Implantable Electronic Device Infections
PROJECT SUMMARY/ABSTRACT Infections related to cardiac implantable electronic devices (CIEDs) are associated with significant morbidity and mortality. The capability of bacteria to...
Understanding the role of arginine metabolism in antibiotic treatment failure during Staphylococcus aureus infections
PROJECT SUMMARY Staphylococcus aureus is a leading cause of a wide range of bacterial infections globally and the most common bacterial cause of mortality in the United States. The...
Early and Personalized Cardiovascular Disease Preventive Care in Lupus Nephritis (EPiC-LN)
PROJECT SUMMARY/ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality in patients with lupus nephritis (LN). Moreover, LN patients of Black race...
The effects of adolescent alcohol use on oral microbiota and the brain
PROJECT SUMMARY Research on the microbiome-brain axis indicates strong bidirectional communication systems between the microbiome (including the oral microbiota) and the brain. In...