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606,025 grants found
Showing 33,801 – 33,820 of 606,025 grants
Project 2: mRNA vaccine development against Bunyaviruses, Paramyxoviruses and Picornaviruses
Project Summary/Abstract – Project 2: mRNA Vaccine Development against Bunyaviruses, Paramyxoviruses and Picornaviruses As the emergence of new pathogenic outbreaks in the future i...
Project 3: Peribunyaviridae Pathogenesis and Vaccine Testing
Project Summary/Abstract – Project 3: Peribunyaviridae Pathogenesis and Vaccine Testing The orthobunyaviruses (OBVs) of Peribunyviridae cause disease in humans manifesting with fev...
Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential
Project Summary/Abstract – Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential Picornaviruses are the mos...
Bunyavirus and Picornavirus Pandemic Pathogen Preparedness (BP4) Center
Project Summary Pathogenic picornaviruses and bunyaviruses have an enormous impact on public health worldwide, and our understanding of mechanistic correlates of immunity for membe...
Admin-Core
PROJECT SUMMARY - CORE A The central offices and administrative staff of the Vanderbilt Vaccine Center (VVC) will house the BP4 Administrative Core, which will play a critical role...
Data-Management-Core
PROJECT SUMMARY- CORE B The Data Management and Sharing (DMS Core) will be integral to the Bunyavirus and Picornavirus Pandemic Pathogen Preparedness (BP4) Center. The DMS Core wil...
Structural Biology Core
PROJECT SUMMARY - CORE C Bunyaviruses and Picornaviruses are RNA viruses that cause outbreaks of human disease. Given their diversity and mechanisms of transmission, they represent...
Vaccines and Therapeutics Technology Core
PROJECT SUMMARY - CORE D The Vaccine and Therapeutics Technologies (VTT) Core will focus on developing a rapid pipeline for next- generation vaccine and therapeutic antibody candid...
Virologic and Immunologic Sample Acquisition Core
PROJECT SUMMARY – CORE E Virologic and Immunologic Sample Acquisition Core (VISAC) Preparedness for the next pandemic relies upon improved understanding of both emerging viruses an...
Design and testing picornavirus vaccine candidates
PROJECT SUMMARY – RP1 Design and testing of picornavirus vaccine candidates The need for effective vaccines against enteroviruses and rhinoviruses cannot be overstated. Given the e...
Protective human antibodies for picornaviruses
PROJECT SUMMARY - RP2 Picornaviruses are an ever-present threat to human health, causing myriad diseases ranging from mild (common colds, hand, foot, and mouth disease) to more sev...
Nucleic acid vaccines targeting hantaviruses
PROJECT SUMMARY – RP3 RNA vaccines are one of the most promising vaccine platforms available to rapidly deploy in response to emerging viral infections with pandemic potential. How...
Human monoclonal antibodies for hantaviruses
PROJECT SUMMARY – RP4 The hantaviruses represent collections of diverse virus species, and these groups of viruses are ideal for prototype pathogen immunity approaches. The goal of...
Vaccines and antibodies for arenaviruses
PROJECT SUMMARY - RP5 Arenaviruses, a family of viruses with pandemic potential, can cause hemorrhagic fever, meningitis, and other clinical syndromes. These viruses include highly...
Metasurface Optical Guidewire for percutaneous coronary intervention (PCI)
PROJECT SUMMARY / ABSTRACT Coronary artery disease, aggravated by arterial calcification, poses a significant challenge to successful percutaneous coronary intervention (PCI). Coro...
Optimizing Equitable Peanut Allergy Prevention among Infants at High Risk of Peanut Allergy
PROJECT SUMMARY/ABSTRACT Peanut allergy affects one in fifty children in the US with disparities in prevalence and morbidity. There is no cure, and while progress is being made in...
Understanding Mechanisms of Antibiotic Inhibition of Ribosomal Subunit Joining
Project Summary / Abstract Antimicrobial resistance is rapidly on the rise due to the excessive use and over-prescription of antibiotics in agriculture and medicine. Consequently,...
Applied Implementation Research for Clean Cooking in Cambodia (AIR-C3): equity, exposure, costs, and benefits of induction stove interventions
The goal of this study—Applied Implementation Research for Clean Cooking in Cambodia (AIR-C3)—is to design and demonstrate the effectiveness of a scalable strategy for achieving eq...
Nanohybrid Composites Minimize Antibiotic Resistant Infections
PROJECT SUMMARY/ABSTRACT: Open fractures are frequently (more than 150,000 cases in the U.S. every year) seen and have high (~10%) infection rates. Open fracture-associated infecti...
Genetic screens in zebrafish to identify gene-ethanol interactions
Project Summary/Abstract Ethanol is the most common teratogen and the leading cause of mental retardation. Fetal alcohol exposure can cause numerous birth defects, most commonly ef...