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606,025 grants found
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Mesoscale correlative light-electron microscopy (CLEM) computational pathoconnectomes of degenerated retinas
Project Summary To this date, we are still uncovering the exact morphological and functional changes that retina cells undergo throughout retinal degenerative disease timecourse. F...
Identifying the cellular origins of jaw joint cartilage regeneration in zebrafish
PROJECT SUMMARY Temporomandibular jaw joint osteoarthritis (TMJ OA) and other disorders of the TMJ affect up to 12% of the US population. OA in general is the leading cause of disa...
Modulating Blood-Brain Barrier Permeability by TRPV4 activation
Summary The long-term vision of this proposed research is to build the next generation of methods to put medicine into the brain and solve the most challenging and impactful neurol...
Dissecting the contributions of phase separation to yeast transcription .
Summary Transcription requires the coordinated recruitment of transcription factors, coactivators, and regulators to specific DNA elements with high spatial and temporal regulation....
Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda
PROJECT SUMMARY/ABSTRACT Background: People with HIV (PWH) are at increased risk of developing coronary artery disease (CAD) as compared to people without HIV (PWOH). The pathophys...
GLIOMA INTERACTION WITH THE NEUROGENIC NICHE THROUGH EXTRACELLULAR VESICLES
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common, aggressive and proliferative primary brain tumor in adults despite current therapeutic strategies that combine surge...
Bifidobacterium infantis supplementation in early life to improve neurodevelopment in infants exposed to HIV
Higher risk of neurodevelopmental delay during early childhood has been reported among infants who are HIV exposed in utero but uninfected (iHEU) compared to their HIV unexposed co...
Late Neurological Sequelae after Cryptococcal Meningitis
Abstract Despite the success of Cryptococcal Antigen (CrAg) screening and the Test and Treat policy in reducing the prevalence of cryptococcal meningitis, it remains a leading caus...
Development and evaluation of a physical activity intervention for obese people with HIV in rural South Africa.
ABSTRACT People living with HIV (PWH) living in the global south on modern first-line antiretroviral therapy (ART) experience significant increases in body mass index (BMI). Obesit...
Adapting evidence-based stigma reduction interventions to address HIV and drug use stigma among family members of people who use drugs
PROJECT SUMMARY The burden of HIV among people who use drugs (PWUD) is high in Tanzania. No current national data are available in Tanzania on the burden of drug use and HIV among...
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
PROJECT SUMMARY/ABSTRACT Cancer-related cognitive impairment (CRCI) is common and distressing among cancer survivors. An understudied area is the impact of targeted therapies, a ne...
Hippo Pathway in Biology and Diseases
PROJECT SUMMARY The overall goal of this proposal is to obtain funding support for early-career researchers (i.e., PhD students, postdoctoral fellows) and junior faculty to attend...
Multimodal Assessment and Longitudinal Trajectory of Callous-Unemotional Behaviors in Young Children: The Role of Parental Emotion Socialization
PROJECT SUMMARY Conduct problem (CP) symptoms in early childhood, including aggression and defiance, are associated with adverse social, emotional, and behavioral outcomes extendin...
Toward understanding mechanisms of inadvertent lower extremity displacements from wheelchair footplates in Veterans with SCI/D: Multi-modal evaluation of leg movements during power wheelchair use.
Veterans with sensorimotor deficits due to spinal cord injuries and disorders (SCI/D) and other neurological disorders often use power wheelchairs (PWC) for independent mobility. W...
The Translational Glycomics Symposium
Project Summary The 2024 Translational Glycomics Symposium, organized by the Translational Glycomics Center at Versiti Blood Research Institute in Milwaukee, Wisconsin, is set for...
Non-coding RNA Biology: New Roles & Diversity
ABSTRACT Support is requested for a Keystone Symposia conference entitled Non-Coding RNA Biology: New Roles and Diversity, organized by Drs. Sebastian Kadener, Irene Bozzoni and Lu...
2024 Pittsburgh International Lung Conference: From Smog to Social Equity: How the Exposome Shapes Our Respiratory Health
ABSTRACT This application requests partial funding for the 2024 Pittsburgh International Lung Conference (PILC) “From Smog to Social Equity: How the Exposome Shapes Our Respiratory...
Domestication and characterization of TM7-the most elusive oral phylum
Abstract Saccharibacteria (also known as TM7) are ubiquitous members of the human oral microbiome whose relative abundance increases dramatically during mucosal inflammation (gingi...
Applying an Implementation Science Lens to Defragmenting Care for Patients at Increased Risk of Hospitalization: A Conference on Comprehensive Care
Project Summary/Abstract This application requests support for a novel 1-year dissemination and implementation conference grant in which the University of Chicago Comprehensive Car...
Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
PROJECT SUMMARY Over 800 million persons worldwide have chronic kidney disease (CKD) and experience a considerable two-to- three-fold excess risk for cardiovascular disease, starti...