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606,025 grants found
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Engaging Vulnerable Women in HIV Prevention and Health Promotion through a Stigma-Reduction Intervention: A Pilot Study
PROJECT SUMMARY This collaborative project between Beijing Normal University, Brown University, and Emory University responds to PAR-23-190 by developing and testing a stigma reduc...
Kupambana: A Combined Microeconomic Strengthening and Stigma Reduction Intervention for Young People with HIV in Zambia
ABSTRACT In low- and middle-income countries, young people with HIV (YPWH) experience the compounded effects of HIV and poverty stigmas that jointly contribute to suboptimal mental...
Dynamic High-Order Shim System for Improved Neuro-MRI
Abstract The purpose of this proposal to demonstrate the feasibility of building a practical shim sub-system based on a minimally interacting in-bore shim coil using a highly contr...
Executing the IND-Enabling Studies for Oral PCSK9/LDLR antagonist
Project Summary/Abstract Heart disease has been the leading cause of death in the United States and the world for more than a century, ever since the early 1900s. About 697,000 peo...
Transforming mental health care via science-based, personalizable and scalable digital therapeutics
Project Summary_Abstract Mental health problems are increasing worldwide; however, the vast majority of people struggling with mental health challenges do not receive any treatment...
The use of DNA-encoded library (DEL) technology for the identification of therapeutic molecules to treat opioid use disorders (OUDs)
PROJECT SUMMARY The use of DNA-encoded library (DEL) technology for the identification of therapeutic molecules to treat opioid use disorders (OUDs). This Phase I SBIR project aims...
Enhanced Prosthetic Vascular Graft Function by Local Release of Nitric Oxide
ABSTRACT Endograft infection, neointimal proliferation, and thrombosis are the three main clinical complications with ePTFE stent grafts affecting patients following endovascular a...
Targeting biologically relevant tau monomers and oligomers using a novel DEL drug discovery platform to treat Alzheimer’s disease and tauopathies
PROJECT SUMMARY Targeting biologically relevant tau monomers and oligomers using a novel DEL drug discovery platform to treat Alzheimer’s disease and tauopathies This Phase I SBIR...
An advanced dermal regeneration scaffold for skin loss due to burn wounds
ABSTRACT The gold standard treatment for large full thickness skin loss (FTSL) due to burns involves autologous tissue transfer in which the patient serves as their own donor. Howe...
A system to enhance prevention of diabetic foot ulcers and their recurrence
Project Summary/Abstract Problem The prevalence of diabetes mellitus in the U.S. is high and increasing in both adults and children—over 1.5 million Americans are diagnosed with di...
Blood-based Biomarker for Characterizing Progression and Therapeutic Response in Amyotrophic Lateral Sclerosis
In this Direct-to-Phase II SBIR application, NeuroDex, Inc. proposes to advance the development of a new blood-based biomarker TDP43, which is a potential marker of pathological pr...
A CRISP(e)R approach to alleviating HIV-associated COPD
PROJECT SUMMARY People living with HIV demonstrate increased incidence of lung inflammation and HIV is an independent risk factor development of COPD. In the era of antiretroviral...
Evaluating Cascading Effects of Caregiver Stress on Later Language Outcomes of Infants
PROJECT SUMMARY Understanding individual differences in language comprehension and use in autism is a top priority of autism research, as acquisition of language early in life is c...
How genome architecture controls Protocadherin gene choice at single-allele resolution
PROJECT SUMMARY Neural self-avoidance is a fundamental yet poorly understood process that is essential for proper brain wiring. Self-avoidance describes the tendency of neurites or...
SBIR Phase I: Development of the thinnest, most flexible, sustainable and cost-efficient hands-off-detection sensor and steering wheel heating insert for autonomous vehicles
This Small Business Innovation Research Phase I project aims to develop a Hands-Off-Detection (HOD) system for the vehicle steering wheel with integrated heating functionality, add...
Collaborative Research: Mechanics of Tough and 3D Printable Ceramic Nanocomposites
Overcoming intrinsic fragility is a long-standing quest for developing light, strong, durable, and reliable ceramic materials needed for high-demand applications, such as electroni...
Collaborative Research: Live-Cell Applications of Chiral Plasmon-Dye Interactions with Single-Molecule Super-Resolution Polarimetry
With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and co-funding from the Biosensors program in the Division of Chemical, Bioengineering,...
CAREER: Large scale geometry and negative curvature
The symmetries of a space and its relation to the underlying geometric structure of the space has led researchers to deep insights into the connections between algebraic and geomet...
Graduate Research Fellowship Program (GRFP)
The National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) is a highly competitive, federal fellowship program. GRFP helps ensure the vitality and diversity...
SBIR Phase II: EEG-guided intelligent transcranial photobiomodulation to reduce symptoms of autism
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project involves developing a personalized home-based treatment for autistic chil...