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606,025 grants found
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Advanced Provider Care Models and Health Outcomes of Nursing Home Residents with Dementia
PROJECT SUMMARY The quality of care for the over 800,000 residents of US nursing homes (NH) with Alzheimer's disease or related dementias (ADRD) is variable and outcomes are p...
Functions and Mechanisms of Lung Microfold cells during Invasive Pneumococcal Disease
PROJECT SUMMARY Bacterial coinfections have been the leading cause of severe illness and mortality during past Influenza pandemics and current seasonal endemics. Streptococcus pneu...
Pediatric Solid Tumor Microenvironment Atlas
OVERALL SUMMARY/ABSTRACT The majority of solid tumors in children have a unique origin compared to those in adults, stemming from their rise from embryonic cells. Despite this dist...
Augmented Preclinical Alzheimer's Disease Detection Through Wearable Health and Driving Behavior Data.
PROJECT SUMMARY By 2050, 88 million (20%) Americans will be ≥ age 65, representing a doubling of the population along with 25% of all drivers being an older adult. Given that there...
At-home, ultrasonic device for treatment of vulvovaginal atrophy
Abstract Decreases in endogenous estrogen production during and after menopause or cancer treatment is associated with decreased lubrication and thinning of the vaginal tissue, mak...
A Novel Device for Uterine Hemostasis Post Cesarean Section
Project Summary Cesarean sections are the most common surgery in the world. In the US alone, 3,000 are performed each day. Postpartum hemorrhage (PPH) remains the leading cause of...
Development of a Multispectral Kerrison Rongeur for Dura and Nerve Root Detection
PROJECT SUMMARY/ABSTRACT The overarching objective of this Fast-Track Small Business Innovation Research (SBIR) proposal is to create the first Kerrison rongeur (KR) with an integr...
Interactive Gaming Platform to Facilitate Cognitive Interventions for Dementia
Abstract Koronis Biomedical Technologies Corporation (KBT) proposes to develop and validate a novel cognitive intervention to support informal caregivers and family of individuals...
Portable, low-cost cryotherapy system that does not require consumable cryogen gas for the treatment of cervical precancerous lesions
Abstract Cervical cancer deaths have dramatically fallen in high-income countries, but cervical cancer remains one of the leading causes of cancer deaths in low- and middle-income...
ClearWorks Particulate Respirator
PROJECT SUMMARY The ClearWorks respirator, developed by Applied Design Technologies, addresses the critical need for comfortable and effective respiratory protection for healthcare...
Diamond quantum sensor for magnetoencephalography
Imaging the currents in the brain is critical to our understanding of brain function and is an important technique to study neurological disorders such as traumatic brain injury, s...
Lipoprotein (a) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular Disease
PROJECT SUMMARY: People with HIV (PWH) experience a heightened risk of atherosclerotic cardiovascular disease (ASCVD) that is attributed, in part, to chronic inflammation. Lipoprot...
Impact of geographic mobility on PrEP and HIV care outcomes among Latino gay, bisexual and other men who have sex with men
Abstract HIV continues to be a major public health concern for Hispanic/Latino gay, bisexual and other men who have sex with men (GBMSM) in the U.S. Immigrant/migrant Latino GBMSM...
Non Invasive Measurements of Muscle Microstructures Assessed by Diffusion Tensor Imaging
PROJECT SUMMARY Skeletal muscle exemplifies structure-function relationships in biology. The organization of sarcomeres follow hierarchical ordering to form long contractile cells,...
Molecular mechanism of CCDC32 in Cardiofacioneurodevelopmental syndrome
ABSTRACT Craniofacial malformations represent the largest category of birth defects and a major expense to the healthcare system and affected families. As craniofacial morphogenesi...
Understanding the Genetic Contributions to Variation in Ozone Exposure Response
PROJECT SUMMARY Ozone is a common ambient air pollutant that presents a significant public health hazard as a trigger for lung function decrements, airway inflammation, and exacerb...
Investigating the role of Yap/Taz in neural crest-derived cardiac development
Project Summary/Abstract Congenital heart defects (CHDs) are the most common human birth defect. Although CHDs are highly prevalent, knowledge regarding disease onset is currently...
American Sign Language and Spatial Cognition Skills: A Neurocognitive Study Using EEG and Standardized Neuropsychological Assessments
Project Summary/Abstract This research proposal focuses on the relationship between American Sign Language (ASL) fluency and spatialcognition, an area encompassing skills like pers...
Testing Neurobiological Models of Alcohol Use Disorder Through Real World Cue Reactivity and Mood
PROJECT SUMMARY/ ABSTRACT The neuroscientific understanding of alcohol use disorder (AUD) has advanced tremendously over the past three decades. However, translation from preclinic...
Neurodevelopmental Patterns of Social Reactivity in Youth at Increased Familial Risk for Bipolar I Disorder
PROJECT SUMMARY Altered ventrolateral prefrontal cortex (VLPFC) function and brain connectivity are implicated in emotional dysregulation and the emergence of bipolar disorder. How...