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606,025 grants found
Showing 29,081 – 29,100 of 606,025 grants
DDT-IST-000016-LOI-2 A Human Liver-Chip for Prediction of Drug-Induced Liver Injury proposed for context of use claim for the prediction of DILI within preclinical drug development program
RFA-FD-24-030 Application Identifier: 1690535 Project Summary/Abstract: Drug-induced liver injury (DILI) is a leading cause of post-market drug withdrawal, clinical trial failures,...
Gene Therapy in a GALT-null Rat Model of Classic Galactosemia
Classic galactosemia (CG) is a potentially lethal genetic disease that is one of the most common metabolic disorders identified by newborn screening in the United States.Despite ne...
An automated approach for video-based motor assessment in Parkinson's disease
Project Summary Parkinson’s disease (PD) is neurodegenerative movement disorder that causes a series of motor deficits. Due to the degenerative nature of PD, effective management o...
Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar Ataxias
Project Abstract Microsatellite repeat expansions are a growing family of 50+ neurological, neuromuscular, and neurodegenerative diseases that includes the most common cause of adu...
Vascular MicroRNA-212 in CAA and Alzheimer's disease
Supplement Summary and Aims The funded grant aims to determine the role of microRNAs (miRNAs) in post- transcriptional regulation in the context of cerebrovascular dysfunction and...
Trisomy 21 and its impact on hedgehog-dependent gene regulation and differentiation timing
PROJECT SUMMARY The fundamental question for the field of Down Syndrome (DS) basic research is how an extra copy of human chromosome 21 (HSA21) translates into the organ-specific p...
Washington National Primate Research Center
SUMMARY/ABSTRACT This proposal is a request to purchase and install collapsible pen housing for groups of nonhuman primates that support the NIH priorities for HIV-related research...
Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa
PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-24-039.” Cancer mortality rates are projecte...
Neuronal anatomy, connectivity, and phenotypic innervation of the knee joint
Project Summary Severe pain caused by osteoarthritis (OA) affects over 15 million individuals in the United States alone. This degenerative joint disorder not only poses a signific...
Renovation to expand and enhance NHP housing for HIV/AIDS research at the Emory NPRC
PROJECT SUMMARY (from P51): This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the Emory National Primate Research Center (EPC) of Emory...
Assessing effects of air pollution exposure on trophoblast cell mRNA and EV miRNA expression.
SUMMARY Air pollution is a ubiquitous environmental exposure that is consistently linked to adverse developmental trajectories in animal and human studies. However, the definitive...
Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.
PROJECT SUMMARY: It is being increasingly recognized that changes in chromatin state are associated with a wide spectrum of lung diseases, ranging from bronchopulmonary dysplasia (...
Diversity Supplement for “Post-translational regulation of LDLR”
ABSTRACT Elevated plasma LDL cholesterol is the main risk factor in cardiovascular disease (CVD), the leading cause of death in the United States. Cholesterol levels are regulated...
Post-transcriptional regulation of germline mRNAs in C. elegans
Project Summary: My lab is interested in defining how the maternal load is established during oogenesis and decoded after fertilization. We know the identity of most important mate...
Equipment for the sensitive and quantitative detection of proteins and nucleic acids
Project Summary/Abstract A substantial fraction of human inherited disease-causing mutations introduce an early stop codon that truncates protein production and elicits mRNA decay...
Two-way Magnetic Resonance Tuning Nanoprobe Enhanced Subtraction Imaging for Precision Diagnosis of Brain Metastasis
Title: Two-way Magnetic Resonance Tuning Nanoprobe Enhanced Subtraction Imaging for Precision Diagnosis of Brain Metastasis Project Summary/Abstract Metastasis from systemic cancer...
LYMPHEDEMA THERAPY VIA LYMPHATIC TARGETED DRUG DELIVERY
Contact PD/PI: Thomas, Susan Napier PROJECT SUMMARY Lymphedema, which results from the failure of the lymphatic system to properly drain fluid, proteins, lipids, and immune cells f...
Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress among Young Adults with Cancer
Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-041: Administrative Supplements for Asse...
Endometriosis Diagnosis and Subtypes, Reproductive History, and Cardiovascular Disease
ABSTRACT This diversity supplement application is to support the career development of Dhara Richardson, MSPH. Ms. Richardson is currently a PhD student in Epidemiology at the Mel...
3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease
Laser lithotripsy (LL) is commonly used for kidney stone treatment, with cavitation playing a crucial role in stonefragmentation. However, the relationship between cavitation activ...