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606,025 grants found
Showing 29,041 – 29,060 of 606,025 grants
Early Childhood Deprivation and Psychopathology: Identifying Neurodevelopmental Pathways of Risk
PROJECT SUMMARY/ABSTRACT Experiences of childhood adversity are common in the United States and account for a substantial proportion of pediatric-onset psychopathology. Understandi...
Behavioral and neural mechanisms of chemosensation in skin-penetrating parasitic nematodes
PROJECT SUMMARY The goal of this project is to elucidate the behavioral and neural mechanisms that mediate host seeking and host invasion in skin-penetrating, human-parasitic nemat...
Investigating Ensemble Activity Dynamics of a Thalamo-Striatal Circuit Regulating Alcohol Seeking
PROJECT SUMMARY Alcohol use disorder (AUD) is a devastating condition that affects 29.5 million people aged 12 and older. AUD is classically characterized by a loss of behavioral c...
Population coding of complex auditory stimuli in auditory cortex
Project Summary The processing and categorization of complex sounds is a skill critical to interacting with one’s environment for many animals, the disruption of which can negative...
Impact of developmental serotonin on prefrontal cortex parvalbumin interneuron excitability and cognitive behavior
PROJECT SUMMARY/ABSTRACT Sensitive periods are periods during early windows of development in external experiences or exposures can shape patterns of connectivity and behavior late...
Long-range exchange of expectation, experience and error during auditory-motor learning
Project Summary Many of the sensations we perceive are caused by our own actions, which we can distinguish from externally generated stimuli. In the auditory system, the ability to...
The genomic and synaptic basis of language disorder and learned sound association
Project Summary/Abstract Language disorder is a neurodevelopmental condition that occurs in ~7% of children starting school (Tomblin et al., 1997; Norbury et al., 2016). It has hig...
Assessing Parenting at the Momentary Level to Understand Parenting Behaviors that Contribute to Improved Treatment Outcomes for Youth with Co-Occurring Disorders
PROJECT SUMMARY/ABSTRACT. Over 80% of adolescents with an alcohol use disorder (AUD) who present to treatment have a co-occurring psychiatric diagnosis. Although the best available...
Assessing correlation between antimicrobial resistance genes and susceptibility phenotypes for Enterobacter cloacae complex isolates from the Vet-LIRN AMR monitoring program and clinical samples
Project Summary Enterobacter cloacae complex (ECC) are a natural component of mammalian gastrointestinal microbiota (Davin-Regli and Pagès, 2015; Ramirez and Giron, 2020), but also...
Translational BioPhotonics/Additive Manufacuring for Biophotonics
This proposal seeks support for the Translational BioPhotonics / Additive Manufacturing SPIE conference to expand participation of students and young researchers. The financial sup...
Genetic and Neural Sources of Individual Differences in Goal-directed Learning in Health and Disease
PROJECT SUMMARY Throughout multiple species, variations in cognitive abilities can influence an individual’s ability to learn and perform goal-directed behavioral tasks which is cr...
An Acute Exercise Intervention to Ameliorate Behavioral and Neurophysiological Indices of Inhibitory Control Deficits in Schizophrenia: A Mobile Brain/Body Imaging (MoBI) Study
PROJECT SUMMARY/ABSTRACT Inhibitory control deficits are a core feature of schizophrenia spectrum disorders (SSDs), with clear manifestations seen in psychophysiological, electroph...
Pneumonia-induced microglial activation causes blood-brain barrier breakdown, astrocyte activation, and tau pathology
PROJECT SUMMARY / ABSTRACT Many survivors of respiratory infections (i.e., pneumonia, and SARS-CoV-2) have subsequent incident dementia causing decreased quality of life and are at...
Cell-type Specific Roles for H3 Serotonylation During Critical Periods of Postnatal Brain Development and Plasticity
Project Summary/Abstract The serotonergic (5HTergic) system is implicated in a wide range of neurodevelopmental and neuropsychiatric phenomena, including regulation of mood and str...
Synaptic TDP43 in the Adult Mouse Brain
Cognitive impairment due to neurodegeneration plagues 20% of the world population by age 65, yet the mechanistic underpinning of pathogenesis is unknown.The abnormal cytosolic accu...
Building next-generation sequencing (NGS) capacity for One Health and antimicrobial stewardship projects An on-going case study of multidrug-resistant Salmonella in zoo mammals
SUMMARY The overall goal of this project is to build next-generation sequencing (NGS) capacity that will support One Health and antimicrobial stewardship. Currently, the NDSU VDL a...
C-Path Global Impact Conference
ABSTRACT Critical Path Institute (C-Path) is an independent, nonprofit public-private partnership (PPP) with the U.S. Food and Drug Administration (FDA), with a mission to improve...
Impact of Antimicrobial Stewardship Resources on Companion Animal Veterinarians' Intention and Capability to Prescribe Fewer Antimicrobial Drugs
PROJECT SUMMARY Since any antimicrobial drug use has the potential to increase resistance, a key goal is to align antimicrobial drug use (AU) with the prescribing guidelines in vet...
Validation of Endopep-MS for qualitative detection of BoNT/A, /C, /CD, /D, and /DC in animal specimens and feed.
PROJECT SUMMARY/ABSTRACT Botulism is a serious paralytic disease that affects both humans and animals which is caused by botulinum toxins (BoNTs). Animal botulism outbreaks in farm...
Development of analytical methods for detecting microcystins in fish tissue
Project Summary/Abstract Harmful algal blooms (HABs) consisting of cyanobacterial species have been increasing in waterways in the United States and elsewhere due to the impacts of...