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606,025 grants found
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Breakthrough Technology to Expedite the Democratization of High Field MRI
ABSTRACT Technology will be developed to enable future compact, mid-field (0.7 Tesla) magnetic resonance imaging (MRI) systems, for improving human health worldwide. MRI is an indi...
Training Core
The goal of the Harvard Kidney, Urology and Hematology Training Institute’s (HKUHTI) Training Program is to educate the next generation of diverse leaders of KUH research by levera...
Neuroimmune control of lung inflammation
Project Summary: Regulation of immune responses in the lung is a critical determinant of health. While the immune system must respond to viral and bacterial pathogens, these respon...
Mechanisms of PCDH19-clustering epilepsy
PROJECT SUMMARY/ABSTRACT This proposal describes a five-year career development program that will lead the PI to a career as an independent physician-scientist, studying mechanisms...
Training Core
Summary We propose to create a comprehensive training program that encompasses research training in science related to kidney, benign urology, and benign hematology across the life...
Mechanistic investigation of human milk feeding on neurodevelopment: a comparative study using neonatal piglets and translatable biomarkers
SUMMARY/ABSTRACT Approximately 10% of all infants are born prematurely, and up to 50% of preterm infants experience neurodevelopmental delays/disorders. Prematurity is associated w...
Synaptic plasticity mechanisms that protect and refine local circuits
ABSTRACT Synapses form trillions of connections between billions of neurons in the brain to establish neural circuits that allow us to sense, think, act, learn, and remember. Our g...
Preclinical models of serous endometrial cancer from diverse patient populations
Project Summary / Abstract: This administrative supplement is in response to the Notice of Special Interest (NOSI): Administrative Supplements for the Study of the Diverse Aspects...
Midlife obesity and prediabetes trigger later life cognitive decline through central nervous system inflammaging and innate immune dysregulation of cGAS/STING
The size of the aging population is reaching record levels worldwide, causing a parallel increase in the number of individuals with cognitive impairment and dementia, including Alz...
The benefits of nicotinamide riboside upon cognition and sleep in older veterans
Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and...
NIH Aplysia Renewal Year 29 - 33
The proposed diversity supplement will fund a two-year postdoctoral fellowship for Dr. Javier Rodriguez Casariego within the National Resource for Aplysia supervised by co-mentors...
Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatment
7. Project Summary/Abstract This K23 Mentored Patient-Oriented Research Career Development Award involves complementary research and training plans to develop and then pilot a modi...
Improving alcohol and substance use care access, outcomes, and equity during the reproductive years: A Type 1 Hybrid Trial in Family Planning Clinics
Rates of risky alcohol and drug use and alcohol and substance use disorders (AUDs/SUDs) are highest among women during their reproductive years compared to other periods of the lif...
Effect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infection
Abstract The global control of TB is compounded by co-infection with HIV. Those infected with HIV are at high risk of reactivating latent TB infection (LTBI). Decades of research h...
Association between early Candida infection (oral thrush) and severe early childhood caries
PROJECT SUMMARY The proposed K23 career development award in clinical and translational research will form a foundation for Dr. Yuan Liu to become an independent clinician-scientis...
Pathogenesis and Outcomes of SARS-CoV-2 In Utero Transmission - Immunologic and Virologic Evaluations
Importance: Despite effective vaccines, SARS-CoV-2 infection remains a major public health problem for pregnant women and their newborns as they have increased morbidity and mortal...
Molecular and functional characterization of olfactory pathways in the arbovirus vector mosquito Aedes aegypti
Project Summary Abstract Mosquitoes infect hundreds of millions of people with deadly pathogens every year. Since mosquitoes identify humans and other important resources primarily...
The Monarch Initiative: Linking Diseases to Model Organism Resources
ABSTRACT Biomedical researchers need to identify novel disease genes and understand disease mechanisms; clinicians need to diagnose diseases and optimize treatments. An improved un...
Examining reproductive and sexual health during the transition to adulthood
Project Abstract Emerging adults attending community college are an underserved population at risk for poor sexual health outcomes. Compared to students at 4-year institutions, com...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-058.” Lung cancer remains the leading cause of cancer-related dea...