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Active NON-SBIR/STTR RPGS NIH (US)

3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease

$374.6K USD

Funder NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Recipient Organization Duke University
Country United States
Start Date Sep 01, 2024
End Date Aug 31, 2026
Duration 729 days
Number of Grantees 3
Roles Co-Investigator; Principal Investigator
Data Source NIH (US)
Grant ID 11100982
Grant Description

Laser lithotripsy (LL) is commonly used for kidney stone treatment, with cavitation playing a crucial role in stone

fragmentation. However, the relationship between cavitation activities and stone damage remains unclear. This supplement study by Anthony DiSpirito will utilize deep learning to predict stone damage based on passive cavitation mapping (PCM) signals. A three-dimensional PCM system will be employed, along with B-mode Ultrasound (US) for data acquisition. Deep

learning enables the optimization of LL procedures by automating feature selection and identifying key factors driving stone

damage. Our approach will offer valuable insights into medical practice, advancing the efficacy of LL treatments. We will

adopt deep learning module combined with cavitation activities information, and we can better predict the potential damaged

induced by bubble collapsing. Our result will also demonstrate the strong correlation between bubble collapsing information with stone crater damage. This approach can also be further explored with more sophisticated scenarios and clinical applications.

All Grantees

Duke University

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