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606,025 grants found
Showing 29,001 – 29,020 of 606,025 grants
Improving allocation of scarce medical physics resources through a novel, comprehensive quality assurance device.
Healthcare disparities in the US result in large segments of the population without access to radiation therapy (RT). This manifests itself in Eastern Kentucky and Appalachia, wher...
Development of Small-Molecule Degraders of APP as the first-in-class drugs for Alzheimer's therapy
Project Summary/Abstract Alzheimer’s disease (AD) is the most common cause of dementia and currently there is no effective treatment. The amyloid cascade of increased production of...
Refinement of Very Low Leakage Non-Invasive Ventilation Mask for Infectious Patients
PROJECT SUMMARY/ABSTRACT A large number of patients with infectious respiratory diseases such as COVID-19, influenza, and SARS require respiratory support. Noninvasive Positive Pre...
Dysregulated AB in HAND: The Role of GP120 Induced Endoplasmic Reticulum Stress
Project Summary/Abstract: Human immunodeficiency virus (HIV) infection in the brain may lead to HIV-Associated Neurocognitive Disorder (HAND). HAND is characterized by cognitive, m...
Design verification and validation of ViTrack - an accurate, continuous, non-invasive blood pressure monitor
PROJECT SUMMARY Current non-invasive blood pressure (BP) technologies are occlusive arm cuff-based and provide only single- point BP measurements. In US hospitals, 35 million criti...
Targeted Immunotherapeutics In Dysbiotic Microbiomes - A Feasibility and Proof-of-Concept Study
Project Summary Abstract Evimero NCATS P1 OPE Project In the proposed work, we examine the feasibility of using target-specific polyclonal antibodies to intercept and neutralize bi...
Molecular glue degraders for LRRK2
Hijacking the ubiquitin proteasome system (UPS) to degrade undruggable proteins has launched a new era of targeted protein degradation (TPD). Two main drug modalities in TPD field...
Development of an Ondansetron Transdermal Patch for Pregnancy-Induced Nausea and Vomiting
Pregnancy-induced nausea and vomiting (PINV) afflicts 50-85% of all pregnancies, of which there are 4 million each year in the US alone. Symptoms, often disabling and sometimes sev...
Developing blood-based exercise mimetic as a treatment for Alzheimer's disease and related dementias
Project Summary Despite the growing number of adults that are living with Alzheimer’s disease (AD) worldwide, there still lacks disease modifying treatments. Physical activity and...
Environmental forces shape the ecology of virulent parasites in coastal ecosystems
Few studies have characterized disease ecology questions for pathogens with robust environmental stages that cross ecosystem boundaries. In recent decades, terrestrially derived pr...
Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults (MOMENT-V)
PROJECT SUMMARY/ABSTRACT Daily cannabis use among young adults aged 18-26-years is at historically high levels and >4.8 million young adults meet criteria for cannabis use disor...
Investigating Links Between Dysfunctional Parenting and Infant Brain Connectivity on Development of Effortful Control
PROJECT SUMMARY/ABSTRACT Deficits in effortful control (EC; top-down control of self-regulation involving inhibitory control and executive attention) represent a major transdiagnos...
SCH: Machine learning for personalized preventative intervention in perinatal depression
PROJECT SUMMARY (See instructions}: The goal for this project is to develop machine learning (ML) to accelerate the discovery of scalable, interpretable, and personalized preventat...
A longitudinal study of traumatic brain injury in a high-risk population
Contact PD/PI: KIEHL, KENT A Project Summary/AbstractTraumatic brain injury (TBI) is a global public health concern affecting millions of individuals in the United States [1], with...
Diversity Supplement: Cheminformatics-based identification of leukemia-targeting molecules
Contact PD/PI: Kirienko, Natasha V SUMMARY Acute myeloid leukemia (AML) is the most common acute leukemia in the US, with ~20,000 new diagnoses and ~11,000 deaths per year. This pe...
Comprehensive assessment of the diastereomer composition of LEQVIO (Inclisiran) to determine how chemical synthesis impacts biological activity
PROJECT ABSTRACT Nucleic acids are an increasingly popular platform for the development of biotherapeutics to treat and prevent a wide variety of human diseases. The predominate cl...
Local Flavor Policies to Enhance Equity in Tobacco - A Diversity Supplement
ABSTRACT Policies restricting the sale of flavored tobacco products (FTP) are being enacted in localities around the US. We seek to expand the evidence base about the extent to whi...
SCH: Toward a smart, home-use system for noninvasive, personalized monitoring of drug levels
PROJECT SUMMARY (See instructions): To optimize drug dosing, clinicians may order laboratory testing of drug levels in patient blood samples, but the clinical benefit of such testi...
Stigma, Romantic Relationships, and Alcohol Use Among Transgender and Nonbinary Young Adults
PROJECT SUMMARY/ABSTRACT For transgender and nonbinary (TNB) people, anti-TNB stigma is a risk factor for adverse alcohol outcomes, often co-occurring with depression and anxiety....
SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction
SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction This project proposes fundamental novelties (e.g., transfer volume regression) in computer science,...