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606,025 grants found
Showing 29,021 – 29,040 of 606,025 grants
The Safety of Switching Between Complex Branded and Generic Drugs: Developing a Semi-Automated Sequential Surveillance System Using Tree-Based Scan Statistics
Drug-device combinations containing active pharmaceutical ingredients marketed together with their delivery devices are among the costliest medications in the US. Generic competiti...
SCH: Efficient Image-based Hemodynamic Modeling via Physics-integrated Bayesian Deep Learning
This project aims to revolutionize cardiovascular research and healthcare by developing an Al-augmented image-based hemodynamic modeling platform. The primary objective is to estab...
SCH: Robust and Equitable Clinical Decision Support in Glaucoma Detection and Progression Prediction
This project seeks to address the pressing issue of vision morbidity and vision impairment caused by glaucoma. Glaucoma, a complex and multifactorial disease that develops over ext...
SCH: A biomechanics-guided wireless ultrasonic e-tattoo with an application specific integrated circuit for ambulatory blood pressure monitoring
Although ambulatory blood pressure monitoring (ABPM) has been used to detect sources of cardiovascular mortality (e.g., hypertension and abnormal BP rhythms) for over six decades,...
Factors related to drug and Formulation affecting alcohol dose dumping in modified release oral drug products
ABSTRACT/SUMMARY Dose dumping, which is defined as ‘‘unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained i...
Development of PBPK Model-Based Mechanistic IVIVCs for Long-Acting Injectable Suspensions
SUMMARY/ABSTRACT: Long-acting injectable (LAI) suspensions represent a class of complex drug products administered either intramuscularly or subcutaneously and characterized by dep...
Developing PBPK-model based mechanistic IVIVC for PLGA implants
There is an immediate need to understand the critical formulation parameters that may affect product performance in vitro and in vivo, with a goal of developing IVIVCs for long-act...
From Bench to Bioequivalence: In Vitro Mechanistic Understanding of ASD Drug Products in Simulated Gastrointestinal Conditions
From Bench to Bioequivalence: In Vitro Mechanistic Understanding of ASD Drug Products in Simulated Gastrointestinal Conditions – Project Abstract The findings from this project wil...
ML-CFD-DEM Based Reduced Order Models (ROM) to Quantify Variability in Inhalers, Drugs, and Users for Evaluating Comparability of Generic OIDP Complex Products
PROJECT SUMMARY Ensuring accurate predictions of the transport and deposition of orally inhaled drug products (OIDPs) within dry powder inhaler (DPI) flow channels to the human res...
VENOUS ETHANOL ABLATION IN ISCHEMIC VENTRICULAR TACHYCARDIA- VELVET TRIAL
Abstract Radiofrequency (RF) ablation of ventricular tachycardia (VT) in ischemic cardiomyopathy is fraught with limitations due to suboptimal efficacy, risk of complications, and...
Phosphatidylserine signaling in neuronal refinement of the cochlea
ABSTRACT Hearing loss is one of the most common disabilities in the United States and understanding how the inner ear develops and establishes proper communication with the brain w...
Functional characterizations of the genetic etiology of stuttering
ABSTRACT Developmental stuttering is a common speech disorder characterized by prolongations, blocks, and repetitions of speech sounds. Studies of developmental stuttering within t...
Advancing Implementation of Single Session Interventions in Schools
Project Summary. Schools are one of the most common settings where youth seek mental health services, yet existing school-based mental health interventions are often difficult to i...
Antisense oligonucleotide-based upregulation of neurodevelopmental disorder gene MYT1L
PROJECT SUMMARY Therapeutic restoration of protein function is a key goal for many neurodevelopmental disorders (NDDs) caused by genetic haploinsufficiency. MYT1L syndrome is a rec...
Using Real-Time Methods to Investigate Emotion Regulation as a Modifiable Target Connecting Adolescent Social Media Use and Mood
PROJECT SUMMARY/ABSTRACT Adolescent social media (SM) use is linked to adverse mental health outcomes (e.g., depression, anxiety, suicidal thoughts/behaviors) for some adolescents...
Assessing the contributions of the ventral subiculum to the nucleus accumbens shell projection in a novel ethanol self-administration choice paradigm
PROJECT SUMMARY The progression of recreational drinking to alcohol use disorder (AUD) is characterized by increased seeking behavior and loss of intake control, with individuals c...
The role of sleep in neurodevelopmental plasticity and emotion dysregulation in youth
PROJECT SUMMARY Emotion dysregulation, defined as the inability to regulate the intensity and quality of emotions, is a common transdiagnostic symptom of mood disorders in early ad...
Molecular Mechanisms of Type II Spiral Ganglion Neuron Development
PROJECT SUMMARY Hearing function and maintenance relies on the meticulous assembly of spiral ganglion neurons (SGNs). Prior research suggests type II SGNs may act as auditory nocic...
Assessing semantic encoding and decoding models in stroke-induced aphasia
Project Summary People with aphasia struggle to translate their thoughts into language. One potential way to help people with aphasia is using brain-computer interfaces (BCIs) that...
Acoustic Measures in Diagnosis and Subtyping of Childhood Apraxia of Speech
ABSTRACT Childhood apraxia of speech (CAS) is a pediatric speech sound disorder (SSD) that impacts between 60,000 and 780,000 children under 14 in the US. The underlying impairment...