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606,025 grants found
Showing 28,981 – 29,000 of 606,025 grants
Design of Calcium-sensing Receptor Targeted Thera(g)nostic Agents
Summary Calcium-sensing receptor (CaSR), as one of the family C G-protein-coupled receptors (GPCRs), largely modulates extracellular Ca2+ by triggering multiple intracellular signa...
Understanding and preventing heavy drinking and related HIV-risk behavior among active-duty men who have sex with men
PROJECT SUMMARY / ABSTRACT HIV infection rates in the U.S. military have doubled since 2003, yet no interventions targeting HIV transmission in this population have been tested in...
Fourth-Generation Nanopore-Assisted Sequencing for Advanced Oncological Analyses
Project Summary Nanopore-based sequencing has numerous advantages over sequencing-by-synthesis (SBS, the current gold standard for accuracy), including its ability to detect genomi...
Development of a Virtual Health Care Platform to reduce emergency re-hospitalizations in Heart Failure Patients transitioning from hospital to home
Abstract-Summary The overall purpose of this SBIR Phase 1 project is the development and test of nucleusRx’s (NRx) Virtual Care Platform and remote intervention tool targeting post...
Immersive Modular Preparedness Intelligent Tutor for the National Institute for Occupational Safety and Health (IMPRINT NIOSH)
Project Summary/Abstract National Institute for Occupational Safety and Health (NIOSH) hierarchy of controls (HoC) certification programs encompass in-classroom, online, and hybrid...
Innovative Point-of-Use Water Purification System: Portable, Scalable, Efficient, Easy-Use
Innovative Point-of-Use Water Purification System: Portable, Scalable, Efficient, Easy-Use Fresh water in lakes and rivers have supported societies for centuries, unfortunately mos...
Comparison of convection enhanced delivery systems in a randomized controlled clinical study of recurrent Grade 3-4 glioma patients
Project Abstract Significance: The devasting outcomes for glioblastoma (GBM) patients remain despite the advances in cancer therapy. Improved GBM therapy as a critical unmet need r...
Optical sensor-enabled endotracheal tube to reduce esophageal intubation and unintended extubation
Project Summary/Abstract Over 30 million intubations are performed every year in the US. Unfortunately, improper endotracheal tube (ETT) placement (esophageal intubation) and insuf...
A Feasibility and Efficacy Study of NeuroTrainer Cognitive Training in Students With and Without Attention-Related Difficulties
Abstract Attention Deficit Hyperactivity Disorder (ADHD) affects approximately 11% of children and adolescents, leading to impairments in cognitive functions and decreased academic...
Scaling Comprehensively Access to Long-acting for an Effective Use of PrEP (SCALE-UP)
PROJECT SUMMARY Significance. In Africa, AIDS is the leading cause of death among adolescent girls and young women (AGYW). In 2022, 3100 adolescent girls and young women in Africa...
Dual-targeting allogeneic CAR T-cells for universal therapy of T-cell malignancies
Abstract Relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma (TCL) are aggressive hematologic malignancies with limited therapeutic options and...
EleGantry: a software and hardware infrastructure to improve rigor and reproducibility within invertebrate research
PROJECT SUMMARY/ABSTRACT Caenorhabditis elegans is a mainstay of biomedical research and its growth as a model is likely to only increase in time. In particular, C. elegans is used...
Developing a Novel Biologic Therapy to Eradicate Brain Cancer and Brain Metastasis
PROJECT SUMMARY Brain cancers are the leading cause of disease-related death in children and in adults under the age of 40-years old. Even with aggressive treatments that include m...
Dual Agonist Insulins for Treating Diabetics with Impaired Awareness ofHypoglycemia (IAH)
SUMMARY/ABSTRACT Diabetes is a global health crisis. Depending on the type of statistical methodology used, the world-wide incidence of the most common type of diabetes, adult-onse...
New Antimicrobials that Act Via Membrane Remodeling for Critical Gram-Negative Pathogens
PROJECT SUMMARY Antimicrobial resistance (AMR) is an existential threat to global human health, causing ~1.3M deaths and ~50M years of life lost annually. Antibiotics are the corne...
VENTSAFE™ Life Saving Ventilation for the Treatment of ARDS
The goal of this Phase 1 SBIR project is to develop and test a bidirectional synchronous flow-controlled ventilation system to improve oxygenation and ventilation in Acute Respirat...
Expanding synchrotron applications in biomedical research: Myocardial and skeletal muscle imaging at Brookhaven National Labs
ABSTRACT In spite of the rich molecular-scale data provided, clinical applications of high-powered synchrotron radiation for skeletal and cardiac muscle physiology — collectively k...
Monitoring of Oxygen Delivery and Tissue Oxygenation Deprivation in Critically Ill Neonates Using Resonance Raman Spectroscopy
Summary/Abstract Shock physiology, from any cause, is characterized by an inability to deliver sufficient oxygen to the tissues to meet cellular metabolic demands. Unfortunately, t...
Test-to-PrEP: A Randomized Hybrid Implementation/Effectiveness Trial of a Social Network Strategy to Increase Equitable Reach of HIV Testing and PrEP Information
Abstract/Project Summary For this project, we propose a type 3 hybrid implementation-effectiveness randomized controlled trial (RCT) comparing two strategies that engage the social...
Targeted fluorination for improved pharmacology of enzyme replacement therapies
Summary/Abstract: Recombinant protein therapeutics (RPTs) have proven to be an effective method of treating a growing number of medical diseases/conditions. More than 100 approved...