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606,025 grants found
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PCT-KUH: Pittsburgh center for training in kidney, urology and hematology
Abstract The primary goal of the PCT-KUH: Pittsburgh Center for Training in Kidney, Urology and Hematology program is to provide an intensive and structured research experience for...
PCT-KUH: Pittsburgh center for training in kidney, urology and hematology
Professional Development Core Abstract The overall goal of the Pittsburgh Center for Training in Kidney, Urology and Hematology (PCT-KUH) Professional Development Core is to develo...
PCT-KUH: Pittsburgh center for training in kidney, urology and hematology
Abstract The overall goal of the Networking Core is to build a vibrant and dynamic trainee community in kidney, benign urology and benign hematology-based (KUH) research in Pittsbu...
A Consortium for Gut-Brain Communication in Parkinson's Disease
Project Summary/Abstract We plan to initiate participation in the NIH U01 Consortium for Gut-Brain Communication in Parkinson’s Disease (PD) (GBPDC) including contribution of PD pa...
Longitudinal cohort of mushroom intake and cognitive function in the elderly
Project Summary/Abstract: The overall goal of this project is to determine the association of mushroom intake with cognitive function in a middle-aged and elderly cohort conducted...
Trunk control after human spinal cord injury
Abstract Walking recovery is a top rehabilitation goal for many individuals with incomplete spinal cord injury (ISCI). Accordingly, there are extensive resources invested into unde...
Investigating the Microenvironmental Dysregulation and Polypharmacy Impact during Acute Myeloid Leukemia in an in vitro model of the human bone marrow and in vivo models.
Project Summary and Abstract This award will support Azmeer Sharipol, M.S., long-term goal of developing the expertise and skills needed to become an independent investigator explo...
Exploring Historical Trauma, Racial Discrimination, PTSD, and Substance Use Among Black Young Adults
Project Summary Overdose deaths are exponentially rising for Black individuals compared to White, where over 50% of overdose fatalities are associated with polysubstance use. Polys...
Desmoplastic small round cell tumor: harnessing new insights and new models
The desmoplastic small round cell tumor (DSRCT) remains one of the most lethal adolescent/young adult (AYA) sarcomas. The EWSR1-WT1 gene fusion is the primary and defining genetic...
Novel subsampling and analysis of big data using examples from IRIS ® Registry
Abstract Observational studies based on big data from electronic medical records (EMRs) have been conducted recently in many areas of medical research [1, 2]. These results provide...
Alcohol tolerance encoding in sleep and memory circuits
Project Summary / Abstract A single acute ethanol exposure causes lasting changes in behavior and brain function. Acute changes may form a basis for progressive changes with subseq...
Role of altered gut immune response in Lewy Body Disease
PROJECT SUMMARY/ABSTRACT Lewy Body Diseases (LBD), which include Parkinson's Disease (PD) and dementia with Lewy bodies (DLB), represents a spectrum of progressive, debilitati...
Design of a Lay Health Worker Training Intervention to Promote Mental Health Care Access for Racially Diverse Transgender Youth
PROJECT SUMMARY Transgender youth face a high risk for serious mental health problems (e.g., suicidality, depression, anxiety) relative to cisgender youth due to their disproportio...
Connecting across Scales: Integration of Cell-Specific Microstructure within Long-Range Brain Networks in the Macaque Monkey
Project Summary Structural alterations in brain networks are driven by changes in cortical microstructure, including neuronal death, the disappearance or rewiring of a synapse, and...
Chronic alcohol effects on the biogenesis, distribution, and RNA content of astrocytic exosomes
PROJECT SUMMARY/ABSTRACT Neuronal dysfunction underlies the general pathophysiological mechanisms related to heavy alcohol use and development of alcohol use disorder (AUD). Homeos...
Upregulating spinal circuits to enhance balance and walking and to increase spinal excitability in older adults
PROJECT SUMMARY/ABSTRACT A high proportion of older adults are currently or soon will be at risk for the well-known decline in walking and balance abilities that occur with aging....
Airway distensibility and lung inflation effects on the maximal expiratory flow volume curve in elderly adults
PROJECT SUMMARY Both the total number of elderly persons and the incidence of lung disease will increase in the coming decades. It is vital that we define the normal physiological...
Predictive Factors in Language Development Trajectories Over the First 3 Years of Life: Harnessing an Existing Preterm Cohort
ABSTRACT In utero, organized and predetermined patterns of auditory structural and neural pathway development set the stage for early language acquisition.15 The very low birth wei...
PD-1 blockade effects on bone strength and metastatic progression
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) enable anti-tumor immunity by blocking immunoregulatory receptor-ligand interactions (e.g., programmed cell death protein 1 [PD-...
Integrative Deep Learning Models for Multimodal Markers of Cancer Treatment Outcomes
PROJECT SUMMARY The most pressing challenge in oncology is the need for accurate biomarker-driven prognostic/predictive risk- stratification to identify patients who are unlikely t...