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606,025 grants found
Showing 28,521 – 28,540 of 606,025 grants
Adapting an evidence-based intervention to improve HIV testing and PrEP uptake among young men who have sex with men in Vietnam
PROJECT SUMMARY Young men who have sex with men (YMSM) are experiencing an ongoing HIV epidemic in Vietnam, with an HIV prevalence of 12%. However, HIV testing and pre-exposure pro...
Molecular Basis of Left Ventricular Non-Compaction Mutations in Cardiac Myosin
ABSTRACT: Left ventricular non-compaction (LVNC), a rare but increasingly prevalent cause of cardiomyopathy stemming from developmental arrest of myocardial compaction, was identif...
Deep learning approach for the assessment of arterial and arteriolar lesions in kidney biopsies and prediction of cardiovascular risk
PROJECT SUMMARY / ABSTRACT Chronic kidney disease (CKD) is a major public health burden and affects an estimated 10% of the population worldwide. CKD is also a major risk factor fo...
Neurological effects of aerosolized red tide neurotoxins
The observed increased occurrences of harmful algal blooms (HABs) are largely a consequence of ocean warming due to climate change, eutrophication, and nutrient pollution, which ra...
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
SUMMARY/ABSTRACT Breast cancer is a leading cause of death in the U.S. and a major public health burden as one woman out of eight will receive a diagnosis in her lifetime. Advances...
CARMIL1 and Endothelial Barrier Function Regulation
ABSTRACT The acute respiratory distress syndrome (ARDS) is characterized by pulmonary vascular leak and flooding of the normally air-filled alveolar space with protein rich edema f...
Characterizing structural variation at the amylase locus influencing oral health
Abstract Nearly every adult in the United States will develop at least one cavity, with some individuals experiencing a significantly higher incidence. While environmental factors...
PERIFORNICAL AREA OF THE ANTERIOR HYPOTHALAMUS REGULATES METABOLIC BALANCE
PROJECT SUMMARY Obesity is a common, serious, and costly chronic disease that continues to increase in the world. Understanding the causes and determinants of obesity is a critical...
Three-dimensional mapping and modeling of combinatorial interactions underlying biomolecular condensates in olfactory neurons
Summary: Gene regulation is controlled by the dynamic localization of numerous regulatory factors to precise nuclear targets. Classic diffusion and affinity models alone cannot exp...
Determining the relationships between provider bias, experiences of ableism, and health outcomes for people with mobility disabilities
Project Title: Determining the relationships between provider bias, experiences of ableism, and health outcomes for people with mobility disabilities Project Abstract Ableism, the...
Striatal Contribution to the Motor Symptoms and Aphasia in GRN-FTD
Frontotemporal dementia (FTD) represents 10 to 20% of all dementia cases. GRN mutations account for up to 20 percent of familial and 5 percent of sporadic FTD. Homozygous GRN mutat...
Ableism as a Mechanism of Physical and Mental Health Inequities Among Children with Visual Impairment
PROJECT SUMMARY Ableism as a Mechanism of Physical and Mental Health Inequities Among Children with Visual Impairment According to the Centers for Disease Control, approximately 3%...
A Continuing Education Intervention to Address Ableism Among Obstetric Clinicians Providing Perinatal Care
PROJECT SUMMARY The notion that disabled people would seek pregnancy and motherhood defies long-held social norms and is fraught with echoes of the eugenics movement of early 20th...
Integrative Model of Metabolomics, Equol and Atherosclerotic cardiovascular disease (IMMEA)
PROJECT SUMMARY This proposal, IMMEA (Integrative Models of Metabolites, Equol and Atherosclerotic cardiovascular disease), aims to (1) determine the association of equol-producing...
Advancing the Science of Multiple Chronic Conditions in Older Adults
There is increasing recognition that the most common “chronic condition” in older adults is multiple chronic conditions (MCCs).Yet, due to the dominance of a disease-specific appro...
WNK1-dependent macropinocytosis mediates emergency myelopoiesis
PROJECT SUMMARY/ABSTRACT Hematopoiesis ensures the continuous formation and turnover of blood cells during homeostasis, which shifts drastically towards production of inflammatory...
Evaluation of individual FMT as a potential therapeutic to reduce ethanol drinking in mice
Summary Few safe and effective pharmacotherapies exist for alcohol misuse. Alcohol consumption directly effects the gut microbiome, altering its diversity and leading to increased...
Receptor Cd74 integrates meta-inflammation in alcohol-associated liver disease
PROJECT SUMMARY The role of inflammation in alcohol-associated liver disease has been thoroughly researched over the past few decades. Despite this intensive focus on ALD pathophys...
NIHR Senior Clinical and Practitioner Research Award R1
Training Award
NIHR Senior Clinical and Practitioner Research Award R1
Training Award