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606,025 grants found
Showing 28,501 – 28,520 of 606,025 grants
Air Pollution Effects on Child Irritability and Brain Connectivity
Project Summary/Abstract Irritability is common in early childhood and declines as children approach middle childhood. Irritability that persists into middle childhood affects up t...
Evaluating novel transcription factors in regulating astrocyte identity, reactivity, and their roles in neurodegenerative disease pathogenesis
Abstract This proposal leverages a new interdisciplinary collaboration between Drs. Guoyan Zhao and Erik Musiek to define the transcriptional control of astrocyte identities, react...
Women's empowerment as a result of ECOLECTIVOS (WERE)
PROJECT SUMMARY The United Nations and the World Health Organization have stated that empowering women is essential to achieving the goals of health, development, and gender equali...
Developing a novel adenine base editor tool for in vivo alpha-1 antitrypsin deficiency gene correction.
PROJECT SUMMARY Alpha-1 antitrypsin disease (AATD) is caused by mutations in the SERPINA1 gene, which encodes AAT protein. AAT is produced in liver and delivered via serum to lungs...
The Role of Mitochondrial Acid-Sensing Ion Channel 1 in Pulmonary Hypertension
PROJECT SUMMARY The World Health Organization (WHO) defines five broad groups of pulmonary hypertension (PH), including PH resulting from chronic lung diseases and/or conditions ca...
An Evolutionarily Conserved RNA Binding Protein Critical for Proper Neuronal Function Regulates Lipid Storage and Metabolic Pathways
PROJECT SUMMARY Intellectual disability (ID), which affects approximately 1-3% of the human population, is characterized by neurological deficiencies. Genetic forms of ID are often...
Demystifying the interaction of UGGT, the ER folding gatekeeper, with its substrates and co-chaperone
Demystifying the interaction of UGGT, the ER folding gatekeeper, with its substrates and co- chaperone Project Abstract Proteins must fold into specific 3-dimensional structures to...
Adjusting for selection bias due to missing eligibility data in electronic health records-based observational studies
Project Summary Abstract The adoption of electronic health records (EHR) in healthcare has resulted in a hugely promising source of data for public health and medical research. Bec...
Elucidating the role of FBLL1 in ribosome function during neuronal differentiation
PROJECT SUMMARY Chemical modifications of RNA have been seen to have numerous biological consequences including regulation of development. Ribosomal RNA is heavily modified by 2’O...
STUDYING SINGLE NEURON COMPUTATIONS WITHIN BRAIN-WIDE CIRCUITS
PROJECT SUMMARY/ABSTRACT All our sensations, decisions, and actions are mediated by signals flowing through networks of neurons, the fundamental information-processing units of the...
Targeting Surfactant Protein A to Prevent Retinopathy of Prematurity
PROJECT SUMMARY Retinopathy of prematurity (ROP) is a potentially blinding vaso-proliferative disease frequently seen in prematurely born infants with lifelong consequences for bot...
Dissecting intrinsic variability in engineered T Cell immunotherapies
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has revolutionized oncology. Chimeric Antigen Receptor (CAR) T cells in particular have shown dramatic successes in some liquid tumors...
Predicting epilepsy surgery outcomes from individualized resting state functional anomalies
Project Summary/Abstract: This proposal details a 5-year plan to provide the candidate, Dr. Taha Gholipour, with the knowledge and expertise to become an independent investigator....
Insulin's acute regulation of hepatic glucose utilization
Project Summary Insulin controls hyperglycemia after feeding by stimulating glucose uptake and suppressing endogenous glucose production. The liver contributes 90% of endogenous gl...
A Multi-Method Investigation of the Role of Reward-Related Impulsivity in the Development of Alcohol Expectancies in Early Adolescence
PROJECT SUMMARY/ABSTRACT Broad/Long Term Objectives: The goals of this application are to: 1) conduct a novel test of the Acquired Preparedness Model (APM) examining the moderating...
Multiscale mechano-metabolic regulation of fibrous tissue homeostasis
ABSTRACT Meniscus tears are one of the most common knee injuries and often fail to heal in adults. Current surgical treatments increase osteoarthritis (OA) risk, especially in pati...
Neuroepigenetic mechanisms of alcohol response
PROJECT SUMMARY The overarching goal of the research presented in this application is to reveal the fundamental and conserved genetic and epigenetic programs that encode and transm...
Investigating the regulation of cancer cell death by NFE2L1
Project Summary Resistance to therapy is responsible for 90% of cancer patient mortality. Our understanding of how cancer cells resist therapy-induced death is limited. My goal is...
Investigating the Role of Systemic Sex Hormones on Photoreceptor Degeneration
PROJECT SUMMARY There is growing evidence that some diseases can be influenced by biological sex, where male or female patients have worsened outcomes or faster disease progression...
A multi-level study of the link between fear of deportation and mental health in Latinx young adults: The role of systemic inflammation and related risk and protective factors
PROJECT SUMMARY/ABSTRACT There is evidence of a growing health disparity in mental health—particularly rising depression and anxiety—in Latinx young adults. Fear of deportation is...