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606,025 grants found
Showing 28,481 – 28,500 of 606,025 grants
Promoting Activated Natural Killer (NK) Cell Accumulation in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, with a 5-year survival rate of only 12%. Immunotherapy, such as anti-...
Characterization of the role of ZSWIM8 and target-directed microRNA degradation in hematopoiesis
PROJECT SUMMARY Thrombocytopenia (low platelet count) is a significant problem that can cause life-threatening hemorrhage. Platelets are produced by megakaryocytes (MKs), which dif...
Microbiome profiling of non-healing filarial lymphedema wounds in Ghana.
Project Summary/Abstract This proposal presents a five-year research career development program focused on advancing the field of microbiome in non-healing filarial lymphedema woun...
Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida
ABSTRACT Neural tube defects (NTDs), including spina bifida (SB), have a devastating impact on the health and development of infants and children, with economic, social, and physic...
Community and big-data system approaches to identifying and understanding the health impact of xylazine
PROJECT SUMMARY The US opioid crisis has been worsened by the emergence of fentanyl adulterated or associated with the veterinary sedative xylazine (FAAX). Designated by the White...
Adaptation and feasibility testing of an AI-enabled web app based on acceptance and commitment therapy for family caregivers of people with dementia
Project Summary/ Abstract The greatest unmet need in family caregivers of persons living with dementia (PLWD) is support for these caregivers’ mental health. Family caregivers of P...
Impact of physician, hospital, and skilled-nursing facility factors related to geriatric care on days spent at home among persons with AD/ADRD
Abstract Although many persons living with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) prefer to remain at home as long as possible, they spen...
Aging and Metabolic Dysfunction Drive Disrupted Alveolar Epithelial Progenitor Function in Pulmonary Fibrosis
Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown cause marked by dysfunctional wound healing and aberrant fibrotic remodeling of the lung that claims...
The Role of the Exposome and Allostatic Load in Risk and Resilience to Youth Suicide Attempts
ABSTRACT Suicide is the second leading cause of death in US youth. Suicidal behavior is complex and is influenced by a combination of multi-level distal and proximal environmental...
Immigrant Integration and Health: Multidimensional and Cross-National Analyses Over the Life Course
Project Summary Title: Immigrant Integration and Health: Multidimensional and Cross-National Analyses Over the Life Course. Older immigrants of color have high levels of cognitive...
AI-Campus Workshops: Revolutionizing Healthcare with AI and Machine Learning to Promote Diversity and Inclusion
Project Summary The healthcare sector is undergoing a transformation driven by artificial intelligence and machine learning (AI/ML) technologies, which offer potential for enhancin...
Systems Approach to Understanding Cardiovascular Disease - Ion channels, Ca2+ regulation and signaling
UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiovascular Disease -Ion Channels, Ca2+ regulation and signaling- Cardiovascular diseases, including hyperten...
Exploring synaptic actin-myosin dynamics with super resolution microscopy
Project Summary Nonmuscle Myosin IIB (NMIIB) is an ATPase motor complex that generates force on actin filaments. This force generation is an essential driver of the actin re-organi...
Determining themechanism of maternal IL-10 restriction of fetal emergency myelopoiesis to improve neonataloutcomes
PROJECT SUMMARY/ABSTRACT Maternal infections during pregnancy lead to adverse outcomes for the offspring, including short-term outcomes such as intrauterine fetal demise, preterm d...
Understanding diabetes and related-risk factors among adolescents of American Samoa
SUMMARY Pacific Islanders in the US are disproportionately affected by diabetes, obesity, and hypertension. Among US Pacific Islanders, those most at risk are resident in the US-af...
Complementary pathways of necroptosis in recipient and donor lung tissue that drive primary lung allograft dysfunction
In this proposal, we aim to address a critical challenge in lung transplantation: primary graft dysfunction (PGD), a severe complication impacting over half of all lung transplant...
Exploring the consequences of differential immune investment on molecular aging phenotypes in subsistence-level populations
PROJECT SUMMARY Worldwide, the number of adults over the age of 60 will double to 2.1 billion by 2050, leading to an enormous rise of age-related, non-communicable diseases (NCDs)...
Role of Rasa1 in embryonic development
PROJECT SUMMARY Vascular and lymphatic anomalies comprise a spectrum of defects that originate in embryonic blood or lymphatic vessels and are present at birth. These defects can b...
Social Connectedness in People with Amyotrophic Lateral Sclerosis: The Impact of Dysarthria, Immobility, and Psychosocial Factors
PROJECT SUMMARY People living with amyotrophic lateral sclerosis (ALS) are at high risk for social disconnection (such as isolation and loneliness) as their impairments progressive...
Investigating DNA polymerase O in replication stress and cancer therapy
Principal Investigator: Wu, Xiaohua Project Summary Replication stress often occurs when DNA replication is disrupted, leading to DNA double-strand break (DSB) formation. Replicati...