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606,025 grants found
Showing 28,461 – 28,480 of 606,025 grants
Optimization of anal cancer screening for people with HIV using genomic methods
PROJECT SUMMARY Anal cancer represents approximately ~10% of all solid cancers among people with HIV (PWH) and is responsible for ~4% of all mortality in this group, representing a...
Characterizing human exposure to microplastics during pregnancy
Global plastic pollution is a significant environmental and public health concern. Plastic production has increased since the 1950s, reaching approximately 368 million metric tons...
Timing and risk factors for developing chronic respiratory failure after pediatric sepsis
ABSTRACT Each year in the US, over 70,000 children are hospitalized with sepsis. Of the nearly 90% of children who survive sepsis, many face physical, emotional, and cognitive morb...
Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord fMRI in Chronic Hemiparetic Stroke
PROJECT SUMMARY Approximately 60% of hemiparetic stroke-survivors experience significant chronic motor deficits in their paretic upper limb, typically caused by damage to the corti...
Enhancer RNAs and enhancer-centric gene regulatory networks in vascular dementia
Recent studies have reported widespread transcription of mammalian enhancers into noncoding RNAs in a stimulus-dependent manner. Growing evidence shows that these RNAs, known as en...
Disentangling the genetic mechanisms of endometriosis severity with single-cell multi-omics
ABSTRACT Around 10% of reproductive-age women have endometriosis, but the molecular drivers of this common chronic gynecologic condition are poorly understood. Endometriosis is a m...
The choice of vasopressor to prevent postoperative acute kidney injury after major non-cardiac surgery: a multicenter pragmatic cluster cross-over randomized trial (the VEGA-2 trial)
PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): Legrand, Matthieu TITLE OF PROPOSED STUDY: The choice of vasopressors to prevent postoperative acute kidney injury after major non-car...
Development of a Novel Diagnostic Modality for Upper Airway Obstruction via Integrating Dynamic Computed Tomography with Computational Fluid Dynamics
Project Summary/Abstract In the current state, clinical airway management decisions for patients with upper airway obstruction (UAO) are made based on a combination of qualitative...
A domain-specific approach to falls efficacy and walking activity in individuals with chronic stroke
Summary Individuals with chronic stroke are characterized by low levels of walking activity, which negatively impacts post-stroke health and the risk for recurrent stroke. Although...
Regulated PTEN expression to overcome barriers to corticospinal tract regeneration after spinal cord injury
Project Summary: 30 lines of text (Currently 28): Spinal cord injuries (SCI) disrupt the communication pathways in the spinal cord, leading to paralysis, primarily affecting the co...
Randomized trial of Veteran peer navigators to promote Shared Decision Making for PSA screening
Background: Prostate cancer is the most common non-cutaneous malignancy among men in the United States, accounting for one third of VA’s new cancer diagnoses. The United States Pre...
Evaluation of digital ischemia in scleroderma with multiparametric MRI
PROJECT SUMMARY/ABSTRACT Systemic sclerosis (SSc) or scleroderma is a chronic multisystem autoimmune disorder. The underlying pathophysiology includes innate/adaptive immune system...
Enhancement and further development of informatics methods for long-read cancer sequencing
Project Summary Long-read sequencing is rapidly transforming our knowledge of the human genome as well as the approach to uncovering human genetic variation and alterations. In con...
Tailoring a Telemedicine Hypertension Management Intervention for Black Patients
PROJECT SUMMARY/ABSTRACT Clinic-based hypertension care falls short in achieving blood pressure control, particularly for Black patients with hypertension. Sporadic clinic visits d...
Dynamics of Ghanaian immigrants' health in the US: Critical life-stage experiences, social networks, acculturation and selection (GMHeS)
PROJECT SUMMARY: Sub-Saharan Africa (SSA) has the world’s fastest-growing population and SSA-US migration is growing rapidly, contributing to greater demographic heterogeneity and...
Digital phenotypes from a low-cost smartwatch to inform early detection of Alzheimer's disease and related dementias
PROJECT SUMMARY/ABSTRACT Currently, more than 6 million Americans are suffering from clinical Alzheimer's disease and Alzheimer's related dementias (AD/ADRD). By 2050, th...
Tumor-cell intrinsic and extrinsic determinants of drug resistance and metastasis
PROJECT SUMMARY Despite advances in cancer therapy, metastatic disease is overwhelmingly fatal and accounts for most cancer- related deaths. Systemic therapies fail to control diss...
Translational Studies toward Cell Therapy for Treatment of Primary Open Angle Glaucoma
Decreased visual ability in veterans quickly leads to functional impairment and with it, reduced quality of life. In the year 2016 eye care was the third busiest clinical service i...
Comparative analysis of M-CSF and GM-CSF in human monocyte metabolic reprogramming and differentiation into tumor-associated macrophage-like cells
PROJECT SUMMARY A major component of the tumor microenvironment, tumor-associated macrophages (TAMs) play a critical role in the orchestration of immunosuppression, cancer cell pro...
Examining the conditionality and time dynamics of evolutionary constraint in yeast
Project Summary The idea of evolutionary constraint is central to understanding of how populations have and will adapt(ed) in response to heterogeneous selective pressures. Constra...