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606,025 grants found
Showing 28,041 – 28,060 of 606,025 grants
The role of language acculturation in the hearing loss-cognition association among Hispanics in the US
Project Summary Our project focuses on the high prevalence of Alzheimer's disease and related dementias (ADRD) among the Hispanic population in the United States. In 2014 ADRD...
Development and function of corneal lens-secreting cells
The human cornea is a precisely curved transparent structure composed primarily of extracellular matrix (ECM) that is able to refract light and focus it on the retina. Genetic defe...
[R01] Prioritizing food systems interventions to reduce adolescents’ nutrition insecurity and malnutrition in low-income settings
ABSTRACT Nearly one third of the world’s population lacks access to adequate food, and over three billion people cannotafford a healthy diet. Nutrition insecurity - the lack of con...
Effect of obesity on Achilles tendon homeostasis and healing: Disentangling mechanical load and metabolic syndrome
PROJECT SUMMARY. Candidate: Dr. Zellers is a physical therapist (Doctor of Physical Therapy, Columbia University) with a PhD in Biomechanics and Movement Science (University of Del...
Neuronal activity-responsive DNA repair mechanisms and cognitive aging
Project Summary: Accumulating genomic damage to neurons is a cardinal feature of Alzheimer’s disease and the normal aging process. Although cognitive stimulation has been shown to...
Localized small molecule delivery to improve tendon-to-bone integration following anterior cruciate ligament reconstruction
Anterior cruciate ligament (ACL) injuries are one of the leading causes of training and sports related injuries and contribute to post-traumatic osteoarthritis. Torn ACLs are commo...
Neural mechanisms of flexible visual-oculomotor decision rules
PROJECT SUMMARY Visual decision-making in the brain is thought to depend on two behaviorally distinguishable computational components: one that converts uncertain visual inputs int...
Neural Signature Changes Across Early Abstinence in Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Alcohol use accounts for 1 in 5 deaths of individuals aged 20 to 49-years old, and Alcohol Use Disorder (AUD) is associated with deficits in brain structur...
Simultaneous Downfield and Upfield proton MRSI at 3T
PROJECT SUMMARY In the past, nearly all clinical and research proton magnetic resonance spectroscopy (MRS) studies of human brain metabolism have focused on the resonances upfield...
The Financial Impact of Burnout and Mental Health on Hospitalist Turnover and the Contribution of Work Structures and Environment
PROJECT SUMMARY/ABSTRACT Hospitals across the United States are increasingly relying on physicians and advanced practice providers who care for hospitalized patients (hospitalists)...
Robotic OCT for automated mapping of outer retinal layer thicknesses
PROJECT SUMMARY This Exploratory/Developmental Research Grant proposal seeks to advance the state of the art in diagnostic ophthalmic imaging with a novel, robotically-aligned opti...
CytoFLEX LX flow cytometer
Project Summary: Acquisition of a CytoFLEX LX Flow Cytometer The Integrated Imaging Center (IIC) at Johns Hopkins University is applying to purchase a Beckman Coulter CytoFLEX LX f...
Thermo IQ-X high-resolution mass spectrometer
Project Summary The requested instrumentation in this proposal is an ultra-high resolution mass spectrometer coupled to an ultra-high performance liquid chromatography system that...
SkyScan 1276 uCT for multi-user biomedical studies
Project Summary/Abstract. The overall goal of this project is to replace the current micro computed tomography (micro-CT) at Nova Southeastern University (NSU) which is near to end...
Replacement of a pumped 11.74-T Small-Animal MRI Scanner with a 15.2-T System
Project Summary/Abstract This S10 High-End Instrumentation grant application from Washington University (WU) in St. Louis requests funds in partial support of the purchase of a Bru...
Targeting GARP-TGFbeta for Immunotherapy of Non-Small Cell Lung Cancer
PROJECT SUMMARY Although immune checkpoint blockade (ICB) has become a standard cancer therapy, most patients – including ~70% of those with non-small cell lung cancer (NSCLC) – fa...
Analytic diagnosis methods for disease ruling
PROJECT SUMMARY/ABSTRACT Disease ruling, that is, ruling-out or ruling-in, is a main objective of cancer diagnosis to aid in medical decision making. Taking prostate cancer as our...
Intrathecal baclofen and pediatric dystonia.
Over 11,000 infants are diagnosed annually with cerebral palsy (CP) with lifetime medical costs >$1.4 million/person. Elevated muscle tone includes dystonia (involuntary muscula...
Identifying Hidden Relational Processes that Fragment Care for Older Adults with ADRD and Multimorbidity: A Social Network Analysis Approach
Abstract Background: Care fragmentation is a major challenge for older adults living with Alzheimer's Disease and Related Dementias (ADRD) and multimorbidity. Those in this po...
Nonviral Delivery of CRISPR-Cas9 into Hepatocytes Combined with APAP Selection for Treatment of Familial Hypercholesterolemia
PROJECT SUMMARY Familial hypercholesterolemia (FH) affects 1 in 250 people and is characterized by impaired low-density lipoprotein (LDL) metabolism resulting in premature cardiova...