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606,025 grants found
Showing 28,021 – 28,040 of 606,025 grants
Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
The methods used to measure NAD+ and NADH in human samples include the enzymatic cycling assay, high pressure liquid chromatography and liquid chromatography tandem mass spectromet...
Mycobacterial Epigenetics: Investigating the impact of DNA methylation on antibiotic tolerance and persistence
PROJECT SUMMARY Sterilization of tuberculosis (TB) requires lengthy chemotherapy treatment to eradicate persister Mycobacterium tuberculosis (Mtb) sub-populations. Persister Mtb ar...
Towards a molecular biology of human olfaction in health and disease
Project Summary/Abstract The olfactory epithelium is the peripheral organ for smell, housing millions of primary olfactory sensory neurons. Insults such as inflammation, infection,...
Characterizing brain-periphery cortisol dysregulation in AUD
PROJECT SUMMARY/ABSTRACT Alcohol directly stimulates the hypothalamic-pituitary-adrenal (HPA) axis, a primary stress system, initiating the release of glucocorticoid hormones. Prec...
Director Genomics Shared Resource
PROJECT SUMMARY / ABSTRACT The current application seeks salary support for Prashant K. Singh, PhD who serves as the Director of the Genomics Shared Resource (GSR) at Roswell Park...
Artificial Intelligence for effective communication to promote vaping cessation on social media
PROJECT SUMMARY The National Youth Tobacco Survey showed the prevalence of e-cigarette use among high school students has skyrocketed from 12% in 2017 to 28% in 2019 and remains hi...
Mitochondrial nutrient transport and trophoblast differentiation
PROJECT SUMMARY Diabetes and obesity in pregnancy cause abnormalities in placental development that underlie adverse pregnancy outcomes such as spontaneous abortion, preeclampsia,...
Development of Protein Degraders Targeting EZH2 Non-enzymatic Functions in Prostate Cancer
Summary Prostate cancer (PCa) is the most commonly diagnosed non-skin cancer in American men. A majority of localized PCa can be effectively managed by radiation and surgery, with...
Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE
Abstract: Intratelencephalic (IT) excitatory cortical neurons project only within telencephalic structures – the cortex and striatum – and make only callosal, corticostriatal, and...
Impact of Environmental Stressors on Ischemic Stroke Outcome Inequities in Alzheimers Disease and Related Dementias
Persons with Alzheimer’s disease (AD) and AD-related dementia (AD/ADRD) are vulnerable to heat-illness, particularly in socioeconomically disadvantaged neighborhoods, due to limite...
Impact of Medicare and Medicaid Financial Policies on Post-acute and Long-term Care for Persons Living with Dementia
Project Summary: The current proposal, developed in response to RFA-AG-24-031 (Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care) will leverage the last 1...
Investigating epigenetic mechanisms of cancer
Project Summary Disruptions of epigenetic mechanisms that regulate gene expression are frequently found in cancer and collaborate with genetic alterations to drive cancer phenotype...
Predicting Post-Covid Pulmonary Fibrosis with Explainable Deep Learning and Optimal Biomarker Discovery
PROJECT SUMMARY Since the beginning of COVID-19 (SARS-CoV-2) pandemic, we have seen a number of prominent variants, and two of them are very recent. COVID-19 continues to affect mi...
ADVANCE Cancer Health Disparities Research (CHDR) Training Program
ABSTRACT The ADVANCE Cancer Health Disparities Research (CHDR) Training Program at the University of Southern California (USC) is based on a strong foundation of biomedical researc...
The next generation of liquid biopsies: Predictive and pharmacologic biomarkers
Project Summary: The laboratory of Dr. Joshua Lang is focused on targeting treatment resistant PCa through developing new biomarkers for precision medical strategies using liquid b...
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to Therapy
ABSTRACT Fetal reversion is a novel regenerative phenomenon in which cells of the intestinal epithelium respond to damage by downregulating the normal gene expression program obser...
Development and Deployment of Liquid Biopsies in Bench Research and Clinical Trials in the UW Circulating Biomarker Core
Minimally invasive liquid biopsies have revolutionized our understanding of cancer biology and emerged as biomarkers for disease monitoring and drug development, but have been limi...
Exosome Secretion in Tumor Aggressiveness
PROJECT SUMMARY Exosomes are a type of small extracellular vesicle (EV) secreted from all kinds of cells, derived from endosomes. They have many physiological and pathological func...
Roles of circHIPK3 and HuR in aging gut barrier function
Abstract Despite the on-going debate as to whether there are changes in gut barrier function during healthy aging, clinical studies consistently support an increased risk of infect...
Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed Pharmacogenomics
PROJECT SUMMARY/ABSTRACT Acamprosate and naltrexone are major medications used in the treatment of alcohol use disorder (AUD). However, response to treatment with these drugs is va...