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606,025 grants found
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Chromosome Packing Inhibitors for the Treatment of Eye Infections
Chromosome Packing Inhibitors for the Treatment of Eye Infections ABSTRACT Bacterial eye infections frequently arise as a complication of corrective surgery or contact lens use. Th...
Strengthening the Dementia Care Workforce: Analyzing Economic Policies' influence on Workers and their Patients Living with Dementia
Project Summary The long-term care industry is one of the fastest growing sectors of the economy1, while also creating some of the lowest-paid and lowest-quality jobs. These precar...
Chromatin Dynamics During Epithelial Commitment
Project Summary/Abstract To treat wounds that won’t heal for patients with Recessive Dystrophic Epidermolysis Bullosa, we have developed induced pluripotent cell (iPS)-cell derived...
Cross-Disease Multi-Modality Mapping of the Human Lung
PROJECT SUMMARY The tremendous diversity across human lung diseases presents significant clinical challenges, but also offers remarkable opportunities for capturing high-resolution...
Promoting gynecologic cancer patients with frailty to achieve functional recovery cohort study (PROOF Cohort Study)
Project summary and abstract Approximately 80% of patients with ovarian cancer and 30% of patients with uterine cancer are diagnosed with advanced disease. In the absence of effect...
Mechanisms of chemosensory neuron cilia regeneration
PROJECT SUMMARY Primary non-motile cilia protrude from the cell surface of the majority of metazoan cells and act as cellular ‘antennae’ to sense and transduce environmental inform...
Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
(PLEASE KEEP IN WORD, DO NOT PDF)Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Hematopoietic s...
Modulation of CD8+ T cell differentiation and anti-tumor immunity by metabolic manipulation
PROJECT SUMMARY / ABSTRACT CD8+ T cells are critical determinants of the anti-tumor immune response. The TCF1+ progenitor-exhausted subset of CD8+ T cells is critical to their ther...
Activation of SLFN12 RNase Activity by Dimerization
Velcrin compounds kill cancer cells expressing elevated levels of PDE3A and SLFN12 by inducing complex formation between these two proteins. Velcrin-induced PDE3A-SLFN12 complexes...
Testing development, acceptability, feasibility and costing of MARBAR-Africa (a routine outcome interactive measurement dashboard) for improved psychotherapy outcomes in specialist public health care
Project Summary This is a pathfinder project that will begin by developing a prototype of a dashboard for routine outcomes monitoring in psychotherapy and mental health clinics in...
Endothelial RASOpathies and Vascular Malformations
SUMMARY RAS signaling has been implicated in a wide spectrum of processes central to normal development and disease. Human mutations in RASA1 (a GAP negative regulator of RAS) are...
A culturally tailored anti-inflammatory diet for Hispanic patients with ulcerative colitis
PROJECT SUMMARY Ulcerative colitis (UC) is on the rise globally, including among Hispanic/Latinos (H/L). Despite growing evidence of the importance of diet in UC, few clinical tria...
Evaluating accessory cells to improve homing and engraftment efficiency of CD34+ cells from sickle cell disease patients
As a cure for the life-threatening hemoglobinopathy of sickle cell disease (SCD), gene therapy has immense potential, avoiding the burdens with allogeneic transplant of finding an...
Advancing patient-centered decision making in older adults with venous thromboembolism
PROJECT SUMMARY/ABSTRACT Although venous thromboembolism (VTE) is a disease of aging, the current evidence base neglects older adults’ priorities, which prevents patients and clini...
Water Contaminants and Cardiovascular Risk: the Jackson Heart Study
PROJECT SUMMARY/ABSTRACT In Jackson, MS, decades of under-investment in public water system infrastructure have resulted in severe disruptions to water access and diminished water...
ODAlert: Wearable Device for Automatic Detection of Opioid-Induced Respiratory Arrest
In response to the escalating opioid crisis in the United States, there is an urgent need for effective intervention strategies. Opioid overdoses can induce dangerous respiratory d...
The Role of Phosphoinositides in Influenza Virus Assembly
Influenza virus causes significant illness and mortality in the U.S. and worldwide. Vaccines offer some protection, but must be continuously tailored to mutations of the virus. Som...
Possible transfusion transmitted cerebral amyloid angiopathy: evaluation of transmission of Aβ using the RADAR repository
PROJECT SUMMARY/ABSTRACT Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage (ICH), with a case fatality rate of 30-50%. CAA is characterize...
The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)
PROJECT SUMMARY Pituitary neuroendocrine tumors (PitNETs) are rare and understudied heterogeneous tumors that are detrimental to health causing increased mortality and poor quality...
South African Manganese EnvironmentaL NeuroToxic Effects Research (SMELTER)
Abstract Manganese (Mn) is a well-established neurotoxicant that likely induces neurodegeneration through inflammatory pathways. Millions of people worldwide experience high levels...