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606,025 grants found
Showing 26,541 – 26,560 of 606,025 grants
In vivo Sickle Cell Disease Gene Therapy Using a Novel Virus Like Particle
PROJECT SUMMARY Project Title: In vivo Sickle Cell Disease Gene Therapy Using a Novel Virus Like Particle Organization: GigaMune, Inc. PI: David S. Johnson, Ph.D. β-hemoglobinopath...
5-Minute Point-of-Care Anti-Factor Xa Test for Emergent Patient Management
ABSTRACT We are proposing to develop a multiplexed point-of-care anti-factor Xa (anti-Xa) and hemoglobin test to guide emergent management of bleeding and strokes in patients on an...
Computer vision powered automation of rodent arena for assessment of early Alzheimer's disease.
Project summary Alzheimer's disease (AD) is the most common cause of age-related neurodegenerative disease and dementia. Despite its prevalence and deliberating health consequ...
Automating Tabular Data Extraction to Accelerate Evidence Synthesis and Systematic Literature Review
PROJECT SUMMARY Systematic Literature Reviews (SLRs) provide the safety and efficacy data that inform decision-making throughout the healthcare ecosystem, from regulatory approval...
Optimizing non-invasive focused ultrasound for brain tumor liquid biopsy in a rat glioma model - Phase I
SUMMARY The NeuroAccess system represents a pioneering approach to address the unmet critical need for effective blood-based molecular characterization in brain cancer patients. By...
All-in-one measurement and exercise respiratory strength trainer with biofeedback and adherence tracking capability.
Abstract Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on millions of individuals in the United States, both in terms of health and economic costs. Indi...
Universal Test and Connect: A Pilot Study of Comprehensive HIV Service Delivery in Emergency Care Settings in South Africa
PROJECT SUMMARY South Africa continues to shoulder the highest burden of people living with HIV (PLHIV) in the world. In an effort to minimize the national burden of the HIV epidem...
Center for Neurovascular Engineering Research and adVanced Education (NERVE)
Abstract The imperative for biomedical engineering research and education is underscored by the widespread prevalence of braindiseases and disorders, such as Alzheimer's disea...
Defining cellular and molecular processes underlying adipose tissue dysfunction onINSTI-based antiretroviral therapy
PROJECT SUMMARY/ABSTRACT The introduction of the integrase strand transfer inhibitor (INSTI) class of HIV drugs transformed the treatment of persons with HIV (PWH), offering highly...
Impacts of Telehealth Policies on Inequities in Perinatal Behavioral Health Care Access and Outcomes
Project Abstract: Suicide is now the leading cause of death during the perinatal period, and nearly a quarter of maternal deaths are attributable to behavioral health (BH) conditio...
Participation in the FDA Vet-LIRN Cooperative Agreement Program to strengthen analysis of animal food or animal drug samples that may be adulterated and investigation of foodborne illness outbreaks.
1 Project Summary/Abstract The focus of this proposal is to seek funding for the Arkansas Veterinary Diagnostic Laboratory (AVDL) at the Arkansas Department of Agriculture through...
Building Dendrite Architecture via Microtubule Nucleation
Microtubules (MTs) are a major component of the eukaryotic cytoskeleton, and their formation and activity are a primary driver of cellular architecture. MT formation in the cell re...
Understanding eukaryotic proteasome assembly regulation
PROJECT SUMMARY Proteostasis of thousands of proteins is critical for cell viability, regulated in part by the cell proteasome. This is a large multi-subunit machine that degrades...
Structure and function of the LetA lipid transport family across bacteria and eukaryotes
PROJECT SUMMARY This application details career development and research plans that have been uniquely tailored to facilitate the transition of the principal investigator, Dr. Cris...
Engineered bacterial in situ vaccines against oral cancer.
PROJECT SUMMARY. Immunotherapy has become an emerging standard-of-care (SOC) for many different cancer types. However, only 15-20% of patients receive durable benefit. Other limita...
DMS/NIGMS 1: Disease gene discovery by Markovian gene network
PROJECT SUMMARY (See instructions): In this proposal, we develop new interpretable statistical methodology to advance medical genetic, which seeks to understand the genetic basis o...
Genomic and Developmental Mechanisms of SIX2-Related Frontonasal Dysplasia
Abstract On average, a human genome harbors ~27,000 structural variations (SVs), including deletions, duplications, and other genomic changes over 50 bp in size, which contribute s...
Online and offline multiverse spillover: Mapping the ecology of youth mental health
Abstract Rates of mental and behavioral health disorders are increasing among adolescents coinciding with in- creases in overall time spent engaging with social media and other onl...
RNA and genome regionalization in giant single cells: implications for cellular patterning
PROJECT SUMMARY Cells are the building blocks that comprise and pattern multicellular organisms from plants to humans, and many types of cells themselves exhibit complex shapes and...
The Role of Medically Tailored Groceries in Mitigating Food Insecurity and Improving Pregnancy Outcomes through Clinic-Community Partnerships
ABSTRACT Medically tailored groceries (MTG) generally involve fresh and shelf-stable grocery items to be prepared at home, selected by a nutritional professional based on a treatme...