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Regulatory Mechanisms of PP2A Family Phosphatases
The overall goal of our research program is to gain a comprehensive understanding of the molecular mechanisms underlying the regulation of protein phosphatase 2A (PP2A) family phos...
Identifying new immunotherapeutic targets for endocrine autoimmunity.
PROJECT SUMMARY / ABSTRACT (OVERALL) Autoimmune endocrinopathies include a number of conditions in which the immune system destroys healthy hormone-producing tissues. These conditi...
UCLA ACE Administrative Core
PROJECT SUMMARY / ABSTRACT (ADMINISTRATIVE CORE) The Administrative Core provides critical infrastructure and services that support the proposed ACE research program. The overall g...
Defining the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis
Project Summary: Adipose tissue is a dynamic energy depot that supports metabolic function and survival during fasting. When the ability of adipocytes to dynamically release energy...
Development of new tags for RNA visualization
PROJECT SUMMARY RNA plays numerous roles in biology. In addition to its canonical role in the central dogma as an intermediary between DNA genomes and protein products of translati...
Scalable Computational Methods for Genealogical Inference: from species level to single cells
PROJECT SUMMARY Massive amounts of genomic data are currently being generated, providing unprecedented opportunities for biomedical researchers to characterize various biological c...
Preteen Suicide Risk and Protective Factors Data Coordinating Center
PROJECT SUMMARY/ABSTRACT Suicide is a leading cause of death in youth ages 8–12-years, and rates of suicide in children are increasing. Alarmingly, suicide increased 87% in ages 10...
Physical activity in South Asian Youth
PROJECT SUMMARY South Asian is one of the fastest growing ethnic groups in the United States (US). The striking overweight and obesity prevalence (78%) among foreign-born South Asi...
A community engaged approach to understanding Black fathers' experiences with perinatal care
ABSTRACT: Maternal mortality (MM) and severe maternal morbidity (SMM) have been on the rise, and racial disparities are widening. Rochester is the city with the highest Black MM/SM...
Examination of parent-adolescent shared decision-making about participation in pediatric clinical trials
ABSTRACT Pediatric clinical trials are important for discovering effective medicines, treatments, devices, and interventions designed for children and adolescents. However, recruit...
Using Behavioral Economics to Mitigate Relapse of Problem Behavior in an Intellectual and Developmental Disabilities Population
Project Summary/Abstract Over 2 million people in the United States who have intellectual and developmental disabilities (IDD) engage in some form of problem behavior such as self-...
Genomic regulation in ERF-related craniosynostosis
One of the most common craniofacial birth defects is craniosynostosis (CS), where connective tissue of the sutures that normally separate skull bones is prematurely replaced by bon...
Carrier Free siRNA Conjugates as Disease Modifying Osteoarthritis Drugs
PROJECT SUMMARY/ABSTRACT RNA interference (RNAi) using short interfering RNA (siRNA) is a promising strategy to block disease- causing targets that are difficult to selectively and...
Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV
PROJECT SUMMARY/ABSTRACT Insulin resistance is a driver of type 2 diabetes (T2D). Despite viral suppression, people living with HIV (PLWH) have concerningly high rates of both insu...
Role of Biomechanical Interfaces Created by Focal Adhesion Kinase in Catecholamine Signaling
Pioneering work by our MPI team established biomechanical signals as a critical driver of brown adipose tissue (BAT) function. We demonstrated a new signaling cascade in interscapu...
Technologies to enable safe and effective gene editing in skeletal muscle
Gene editing is moving towards the clinic, but several challenges must be addressed in order for it to be applied to skeletal muscle disease. Adeno-associated virus (AAV) is one of...
Immune responses associated with severe disease in patients with primary dengue infection
SUMMARY Dengue is an emerging global public health threat. Decades of extensive research undertaken primarily in dengue-endemic regions has resulted in the prevailing consensus tha...
Targeting EBV-associated lymphomas
ABSTRACT Epstein-Barr Virus (EBV) is the etiological agent of several hematopoietic malignancies including multiple types of non-Hodgkin lymphoma (NHL). These EBV-positive NHL subt...
Improving Similarity Scoring in Drug Discovery: Solving by Solvating
Identifying molecules with similar shape and characteristics to known ligands has proven useful in several areas of drug discovery and development, from ligand-based virtual screen...
Clutter-GO: Facilitating Delivery and Adherence in Evidence-Based Treatment for Hoarding Disorder via a Patient-Provider Digital Health Tool
PROJECT SUMMARY/ABSTRACT Hoarding Disorder (HD) is characterized by the acquisition of and failure to discard materials regardless of their actual value, resulting in a dysfunction...