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606,025 grants found
Showing 26,501 – 26,520 of 606,025 grants
Characterizing the Function and Regulation of Ycx1, a New Member of the CCX Family of Exchangers
Project Summary/Abstract Calcium ions play critical roles in regulating many biological processes. Mis-regulation of Ca2+ signaling can lead to diseases, and the Ca2+ channels and...
Hyperstable FGF1-FGF2 based therapeutic formulation for wound care
PROJECT SUMMARY Chronic wounds are a serious problem that affects the health and quality of life of patients with diabetes and cardiovascular diseases. These non-healing ulcers are...
Dicarboxylic acid therapy for prevention of kidney injury
ABSTRACT Acute kidney injury (AKI) most commonly occurs in the hospital setting. Hospital-acquired AKI accounts for 22% of all cases worldwide, and nearly 50% of critically ill inp...
Time-of -Flight Mass Spectrometer
Time of Flight-Mass Spectrometer (TOFMS) will be a critical instrument facilitating biomedical research activities in Hampton University (HU) and in the area. In addition, this ins...
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
PROJECT SUMMARY/ABSTRACT. Military-connected mothers (MCM; mothers who are either service members or veterans, or spouses of a service member or veteran) experience significant tra...
Estrogen and Serms as Therapy for Renal Ischemia Reperfusion Injury
Ischemia reperfusion injury (IRI) is a major source of morbidity in renal transplantation (Tx), as well as after cardiac arrest, cardiopulmonary bypass, and trauma. IRI and related...
Temporally scalable recording of brain-wide single-cell physiology
Abstract Many fundamental questions in neuroscience and neurological disorders, such as those associated with learning, memory, sleep, aging, and disease progression, would benefit...
Editing Population Codes For Action
Project Summary In the mammalian brain, action, perception, and cognition arise from the coordination of many neurons working in concert. For decades, neuroscientists have observed...
Individually Measured Endophenotypes to Advance Computational Translation in Mental Health
Stress-related psychiatric disorders (SRPDs) are now the leading disease burden worldwide and diagnoses are increasing in both adolescents and adults. High rates of trauma in the U...
Development of highly parallelized interferometric near-infrared spectroscopy for the real-time non-invasive measurement of cerebral blood flow
SUMMARY/ABSTRACT Currently, stroke diagnosis requires advanced imaging (e.g., CT, MRI) to distinguish stroke from mimics, which affect up to 58% of individuals presenting with clin...
Reporting Quantitative Microstructural MRI Metrics to Stage and Monitor Multiple Sclerosis
PROJECT SUMMARY At least 400,000 people in the United States are affected by Multiple sclerosis (MS), which is the most prevalent chronic inflammatory disease of the central nervou...
Gut Grief! Developing an educational game to teach high schoolers about the gut microbiome
PROJECT SUMMARY The microbiome has become an essential element of biomedical science as recent research has uncovered the connection between human microbiome composition, diet, env...
Development of ADAM Air: A Non-Hormonal Vas Occlusive Contraceptive Device
PROJECT SUMMARY Unintended pregnancies, which are unwanted or mistimed pregnancies, result from either not using contraception or improper use of available contraceptives. These pr...
In crystallo biomimetic oxygenase chemistry within peptidic frameworks
Title: In crystallo biomimetic oxygenase chemistry within peptidic frameworks Abstract: Mononuclear non-heme Fe and Cu sites in oxygenases functionalize the highly inert C–H bonds...
Genetics as a tool to improve phenotypes and associations with human disease
PROJECT ABSTRACT The Cole Lab’s overarching vision is to harness unique characteristics of the human genome to gain deeper insights into the impact of environmental risk factors on...
Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections
Project Summary/Abstract Respiratory disease carries a significant worldwide burden of morbidity and mortality. Currently it is well understood that tobacco smoking is a major caus...
Computational rational design of carbohydrate and nucleic acid drug scaffolds with multiscale dynamics and AI
ABSTRACT Computer aided drug discovery (CADD) can dramatically accelerate and lower costs for the often long and expensive process of drug development. However, most CADD technique...
Chemical approaches for targeting ribonucleoprotein assemblies
PROJECT SUMMARY RNA-protein interactions play a fundamental role in biology through complex processes regulating gene expression programs. Perturbation of native RNA-protein assemb...
Autism in Preterm Birth
PROJECT SUMMARY Autism Spectrum Disorder (ASD) risk is primarily of genetic origins with an estimated heritability of 80% but non-heritable factors are also important in understand...
Characterizing the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS): a fundamental step in the development of a targeted cure for this novel atypical sphingolipidosis
Summary Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is an ultra-rare, devastating, often lethal inborn error of metabolism recognized just five years ago. Most aff...