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606,025 grants found
Showing 26,581 – 26,600 of 606,025 grants
Extending the Ischemic Penumbra in Large Vessel Occlusion Stroke
Project Summary/AbstractDecades of neuroprotection clinical trials for large vessel occlusion (LVO) acute ischemic stroke (AIS) failed to translateclinically. While these clinical...
Ion channel regulation of ATP homeostasis in mycobacteria
The intracellular pathogen Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which has been one of the most deadly infectious diseases globally for deca...
The Molecular Basis of the STIM/Orai Signaling Pathway
Project Summary Spatially and temporally precise Ca2+ signals control a vast spectrum of cellular functions including contraction, secretion, transcription, and growth. These signa...
Expanding the Chemical and Functional Space with Boron-Nitrogen Heterocycles
Project Summary/Abstract The generation of chemical space and its translation into new functions is one of the main goals of synthetic chemistry. The BN/CC isosterism (i.e., replac...
TransRWP - Transregionalism in World Politics
TransRWP aims to understand the emergence, dynamics and challenges of transregionalism in world politics and assess its implications to contemporary international order. 'Tran...
Trustworthy Generative AI for Advanced Industrial DigitaliZation (Trust_Gen_Z)
Purpose and goal:The Trust_Gen_Z project applies generative AI (gAI) to enhance prescriptive analytics in industrial digitalisation. By developing a multimodal framework, we aim to...
Innovation Days Business Sweden Canada
Purpose and goal:The project goal is to create a sufficient basis for Alvenius to make decisions about continued and deeper investments in Canada. This will be done through the fol...
PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment
PROJECT SUMMARY / ABSTRACT Over 50% of youths with type 2 diabetes (Y-T2D) develop diabetic kidney disease (DKD) during adolescence, increasing the risk of early dialysis and death...
Tissue engineered organ-specific cancer metastasis model for cancer research
Understanding the biology of cancer metastases is critical to improving the treatment of cancer. A key challenge in these efforts has been the lack of cancer models that can recapi...
Enhancer for UCP1 transcription and thermogenesis
Obesity, the accumulation of excess white adipose tissue (WAT), has become an epidemic and is associated with chronic metabolic diseases, such as type 2 diabetes. While WAT serves...
Role of Intravenous ultrasound (IVUS) in arteriovenous hemodialysis access dysfunction
PROJECT SUMMARY Almost 600,000 patients with end-stage kidney disease (ESKD) are on hemodialysis (HD) in the United States. An arteriovenous (AV) access is the preferable access fo...
Developmental Impacts of Sleep on Positive Valence Systems and Socioemotional Functioning during Pre-Adolescence
Project Summary Sleep patterns characterized by truncated weekday sleep followed by weekend recovery sleep (‘social jetlag’) often begin to emerge during pre-adolescence (8-12-year...
Biomedical Engineering Social Networks
PROJECT ABSTRACT Thousands of students yearly are drawn to biomedical engineering (BME) by the prospect of a career linking medicine and engineering. Unfortunately, students from h...
Artificial Intelligence Passport for Biomedical Research: Digital Experiential Learning Community for Upskilling in Artificial Intelligence for Biomedical, Behavioral and Clinical Research
Project Summary/Abstract The University of Florida (UF) proposes to develop a nation-wide digital course to upskill biomedical researchers’ expertise in artificial intelligence (AI...
Computational identification of Hirschsprung disease susceptibility genes
Hirschsprung disease (HSCR), or congenital intestinal aganglionosis, is a male-biased, rare developmental defect with multifactorial inheritance, high heritability, syndromic assoc...
Protein turnover estimation from fragment ions and precursor enrichment in heavy water labeled LC-MS experiments
SUMMARY Metabolic labeling with heavy water followed by LC-MS quantifies the turnover of thousands of proteins in vivo. As a cost-effective and easy-to-use stable isotope labeling...
Immigration vulnerability and oral health among Latinx/a/o people
PROJECT SUMMARY/ABSTRACT There are over 62 million Latinx/a/o people living in the United States (U.S.) making them the largest minoritized ethnoracial group in the nation. This la...
Enantioenriched Nitrogen-Containing Small Molecules via Stereoselective Carbon-Carbon Bond Construction
Project Summary/Abstract New pharmaceuticals that contain chirality are typically marketed as single enantiomers. Limitations in enantioselective methods for the synthesis of organ...
Defining brain-body feedback loops mediating stress-induced metastasis
Evidence from human epidemiological studies and animal models reveals that chronic psychological stress influences the evolution, dissemination, and treatment results of neoplasia....
Clinical Studies Investigating Use of the Bionic Pancreas in Pregnancy
ABSTRACT While the use of intensive insulin therapy has reduced maternal and fetal mortality associated with type 1 and type 2 diabetes in pregnancy, the risk of diabetes-related p...