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Genomic Technology Development for Diverse Populations
ABSTRACT: The human reference genome was derived from 20 people, with an individual contributing most of the genetic information. This linear reference does not represent the struc...
Ancestry and sex-related pharmacogenomic and metabolomic signatures of oral anticoagulant response
Oral anticoagulants (OACs), including warfarin and direct oral anticoagulants (DOACs), form the cornerstone of therapy for thromboembolic conditions. However, individual variabilit...
A Novel Personalized Flow Modeling Paradigm for Fetal Aorta and Its Validation with Fetal Cardiac MRI
Congenital heart disease (CHD) is the most common birth defect and a leading cause of death and chronic illness in newborns, infants, and children. Prenatal screening and identific...
Investigating the role of autophagy inducers and peroxisomal proteins in pexophagy
Investigating the role of autophagy inducers and peroxisomal proteins in pexophagy Peroxisomes are critical organelles that house fatty acid ꞵ-oxidation and antioxidative enzymes t...
Extraction and summarization of evidence-based medicine
Project Summary/Abstract Evidence-based medicine (EBM) requires collecting and ranking relevant evidence according to its epistemological strength, aiming to identify the most suit...
Development of a Treatment to Improve Arteriovenous Fistula Function
Project Summary/Abstract: In 2017, there were ~750,000 US patients with end-stage kidney disease (ESKD) who required chronic hemodialysis (HD). The ESKD population in the USA is in...
High-throughput Direct Sequencing and Quantitative Mapping of RNA Modifications using Mass Spectrometry.
Sequencing RNA modifications is challenging due to the existence of over 170 unique chemical nucleotide alterations. tRNAs, constituting about 25% of cellular RNA and decoding 61 m...
Commercialization of a rapid, automated Hi-C platform for sensitive genomic profiling of multiple cancer sample types
ABSTRACT Cancer is projected to affect 20M people worldwide in 2023, with new cases increasing almost 30% in the next two decades. Cancer is a complex disease caused by a vast rang...
Personal Respiratory Isolation System for Safe Transport and Treatment of Patients with Highly Transmissible Infectious Diseases
PROJECT SUMMARY: The goal of this project is to develop a solution that allows for rapid, safe, and scalable initial treatment and transport of patients with highly transmissible i...
Leveraging cell-derived bioparticles for macromolecular delivery
7. PROJECT SUMMARY/ABSTRACT Many emerging therapeutic strategies employ macromolecules, like proteins or RNAs, to manipulate intracellular contents and processes, thus mitigating d...
Response and resistance to chimeric antigen receptor T cell therapy in human solid tumors using spatial multi-omics
Project Summary Engineered T cells that express a chimeric antigen receptor (CAR) specific to tumor antigens have shown exceptional efficacy in hematologic malignancies. However, t...
The Behavioral Cost of Carbon
PROJECT SUMMARY The objective of this project is to generate the first empirical estimate of the behavioral cost of carbon – the human health-related behavioral impacts imposed by...
Juggling Roles: A Study of Diverse Neonatal Intensive Care Unit Parents and Their Work-Family Transition
PROJECT SUMMARY / ABSTRACT Preterm infants are at a heightened risk for developing neuromotor, cognitive, and psychiatric disorders that persist through adulthood. Infants born ver...
Predictive modeling of viral RNA cellular behavior
PROJECT SUMMARY/ABSTRACT Modern biomedical science enjoys an unprecedented ability to identify and describe viral pathogenic mechanisms, as well as characterize the biomolecular co...
Virginia Accountable Health Equity and Action Dashboard (VA-AHEAD): Community Framing of Equity Data to Support Clinical and Translational Science
VIRGINIA ACCOUNTABLE HEALTH EQUITY AND ACTION DASHBOARD: COMMUNITY FRAMING OF EQUITY DATA TO SUPPORT CLINICAL TRANSLATIONAL SCIENCE PROJECT SUMMARY Disease burden, healthcare deliv...
TBI-ADRD Modeling with a Team Science Approach (TBI-ADRD Team Science)
Abstract Summary We hypothesize that we can increase systemically develop a progressive murine TBI-ADRD model with internal and external validity with a “Team-Science”-based two-ph...
Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to Systems
PROJECT SUMMARY / ABSTRACT Language gives meaning to our inner thoughts, interacting with cognitive functions that flexibly manipulate sensory content in mind. Language combinatori...
Sleep, pain, and recovery in kids after pediatric intensive care (SPARK-PICU)
Project Summary More than 250,000 children survive pediatric intensive care unit (PICU) hospitalization each year in the United States, yet we have an incomplete understanding of r...
Supporting Just-in-Time Consent for Prenatal Screening in Diverse Populations
PROJECT SUMMARY/ABSTRACT Prenatal screening for genetic conditions (PGS) has changed the landscape of prenatal care by offering noninvasive indication of some fetal genetic conditi...
An Injectable Electrode to Better Isolate the Posterior Tibial Nerve to Treat OAB
Abstract Urinary urgency, with or without incontinence, greatly affects the quality of life in individuals suffering from Overactive Bladder (OAB). A sudden and often overwhelming...