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606,025 grants found
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Revealing the complexity of dis-inhibitory circuitries
PROJECT SUMMARY Salient signals, like aversive stimulation and reward, should be faithfully detected, and processed by the nervous system to generate an adaptive action. One of the...
OLD family nuclease function across diverse anti-phage defense systems
Project Summary/Abstract Bacteria and the viruses that infect them, termed bacteriophages or simply phages, are locked in a never-ending evolutionary battle. To protect themselves...
AAV-mediated editing to treat human autosomal dominant hearing loss DFNA41 and DFNA2
Project Summary/Abstract 1 in 500 newborns suffers from genetic hearing loss (HL), and there are no FDA-approved drugs or biological treatments for any type of HL. Genome editing t...
Personalized prime editing as a platform for hepatic inborn errors of metabolism
PROJECT SUMMARY Inborn errors of metabolism (IEMs) are rare, devasting disorders arising from pathogenic variants in genes encoding enzymes of key biochemical pathways. The liver p...
Functional diversity of large ribosomal protein 27 and small ribosomal protein 19 paralogs
Project Summary Diamond-Blackfan anemia (DBA) is a rare hemorrhagic disease in which the bone marrow cannot make enough red blood cells, possibly due to issues with ribosomes, the...
Integrate Data-Driven Modeling and Multi-scale Measures Towards Tissue Function
Human tissues are highly organized structures with specific collagen matrix arrangements and the resulting mechanical properties varying from point to point. The effects of such he...
An Explainable Artificial Intelligence Based Hybrid Intrusion Detection System for Enhancing Healthcare Security
The Internet of Medical Things (IoMT) refers to a connected infrastructure of medical devices, healthcare software, and digital health services. This infrastructure transports heal...
DMS/NIGMS 2: Bayesian Statistical Methods for Comprehensive Inferences on Microbial Community Dynamics Using High-Throughput Sequencing Data
We propose to develop flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The emergen...
Regulation of HSP70 function during heat stress tolerance
Project Summary The 70-kilodalton heat shock protein (HSP70) family, universally conserved across prokaryotic and eukaryotic organisms, serves as essential molecular chaperones for...
Rescuing myelination in viral infections of the juvenile brain
PROJECT SUMMARY Viruses are well-established causes of central nervous system (CNS) disease in the most vulnerable populations, particularly in the young and immunocompromised. Dur...
Regulation of Neurodegeneration by Nonpathogenic Cellular Prion Protein and LRP1
Microglial activation and neuro-inflammation regulate disease progression in diverse neurodegenerative di- seases (NDs), including but not limited to Alzheimer's Disease, Park...
Continuation of the Produce Safety Alliance to Enhance Understanding and Compliance with the FSMA Produce Safety Rule
Project Abstract/Summary The project proposes to continue the work of the Produce Safety Alliance (PSA) to educate growers, packers, and other stakeholders involved in the U.S. fre...
PET Imaging of Renal Fibrosis
Project Summary Chronic kidney disease (CKD) is the most under-recognized public health issue in the US affecting more than 35 million adults and it is projected that 47% of 30-yea...
Identifying an immunoregulatory axis for FGF21 in alcohol consumption
PROJECT SUMMARY/ABSTRACT Alcohol abuse is a major health concern with a recently alarming increase in prevalence. Among the various complications associated with alcohol use disord...
Pathological consequences of iron excess and hypoxia in β-thalassemia pregnancy
PROJECT SUMMARY Excess redox-active iron, and consequent oxidative stress, contribute to the morbidity and mortality associated with β-thalassemia. Iron overload develops due to lo...
Mechanistic and clinical outcomes of a surgical innovation aimed at minimizing GERD associated with vertical sleeve gastrectomy (INNOVATE-VSG)
PROJECT SUMMARY Conventional vertical sleeve gastrectomy (cVSG) accounts for approximately 60% of all bariatric surgery procedures. Its popularity is attributable to procedural sim...
Novel primer for bonding and debonding of high-strength dental ceramics
SUMMARY We aim to combine the laser energy with a novel primer for bonding reversibly to high-strength ceramic crowns. This proposal seeks to investigate the novel primer’s bonding...
Mindfulness-Based Relapse Prevention and Psychophysiological Self-Regulation
Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Matison McCool to strengthen his trajector...
Effects of cannabis use on community-based alcohol treatment outcomes in adolescents
PROJECT SUMMARY/ABSTRACT Most (60-90%) adolescents in treatment for alcohol use disorder (AUD) also have a co-occurring psychiatric disorder (COD) other than substance use, and ado...
Cerebellar Nuclei Dysfunction in Spinocerebellar Ataxia Type 1
PROJECT SUMMARY/ABSTRACT SCA1 is a dominantly inherited neurodegenerative disease caused by expansion of CAG repeats in the ATAXIN-1 (ATXN1) gene. Patients with SCA1 suffer from pr...