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606,025 grants found
Showing 23,561 – 23,580 of 606,025 grants
Fine-grained Annotation of the Protein Universe through a Community of Practice
PROJECT SUMMARY The functional annotation of proteins is a major bottleneck of biological discovery in the post-genomic era. We are able to accurately generate large swaths of geno...
1/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)
This submission comprises two applications (Clinical and Statistical Data Coordinating Centers). We propose to enroll all 1000 US participants of a planned 6150 multinational parti...
2/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)
This submission comprises two applications (Clinical and Statistical Data Coordinating Centers). We propose to enroll all 1000 US participants of a planned 6150 multinational parti...
Fecal microbiota transplantation for auto-brewery syndrome
ABSTRACT Auto brewery syndrome (ABS), also known as gut fermentation syndrome, is a rare condition in which a dysfunctional intestinal microbiome produces ethanol, which is absorbe...
Gfastar: a C++ library and a tool suite to aid Telomere-to-Telomere genome assembly
Project Summary The recent completion of a Telomere-to-Telomere (T2T) human genome has demonstrated that, in principle, existing sequencing technologies allow gapless and nearly er...
Hormonal Influences on Inflammation in Endometriosis
ABSTRACT It is estimated that around 10% of reproductive-age women of European ancestry, and 15% of women of Asian ancestry are impacted by endometriosis. In endometriosis, glandul...
MAGNET: MAKING GENOMICS ACCESSIBLE FOR NEWBORNS IN TEXAS
ABSTRACT The great advances made in genomic medicine that impact diagnoses and care of newborn babies in large academic centers in Texas are generally not available at most level I...
Advancing Integrated Treatment for Co-Occurring Opioid and Alcohol Use Disorders: A Comprehensive Analysis of GLP-1 Receptor Agonists and Traditional Pharmacotherapies in Real-World Settings
Project Summary/Abstract The intersection of Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) presents a significant public health challenge, particularly in clinical setti...
Exhaustive de novo sequencing of every RNA in a sample by a layer-by-layer mass spectrometry ladder intensity approach.
An RNA sequence and all its diverse modifications constitutes the true informational content of RNA. Defects in RNA modifications account for >100 human diseases, affecting mill...
Versatile platform for genome-wide R-loop mapping for aging and neurodegenerative disease research
PROJECT SUMMARY R-loops are triple-stranded nucleic acid structures consisting of a DNA:RNA hybrid and a displaced single DNA strand. R-loops are generally transient in nature, but...
Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis
PROJECT SUMMARY Neuromuscular Dynamics, LLC has developed the Leg Dexerity System, a patented portable, wireless device for short-latency sensorimotor circuit neuromuscular trainin...
MiGo Tracker: Seamless Remote Therapeutic Monitoring of Exercise Adherence After Stroke
One in four people will experience a stroke, with 50-70% experiencing chronic movement impairment. While intensive rehabilitation exercise reduces movement impairment, most individ...
Neuroprotective Engineered Bacteria for Alzheimer's Disease Treatment
ABSTRACT Alzheimer’s disease is the most common neurodegenerative disease, and is characterized by the severe deterioration of cognition and memory due to the production of amyloid...
1,3-Thioureas as First In Class Mitochondrial Inhibitors to Treat Oral Cancer
Abstract Keraceuticals is developing a patent-protected novel class of anticancer drugs called 1,3-thioureas for the treatment of oral squamous cell carcinoma (OSCC). OSCC is the m...
Development of Novel Small molecule modulators of synaptic plasticity for the treatment of AD-induced cognitive decline
PROJECT SUMMARY Pharmacological treatment to slow or stop the progression or prevent Alzheimer’s Disease (AD) represents an unmet medical need. Clinical evidence shows that the cor...
An Innovative Immune Therapy Targeting the TREM1-Inflammation Pathway to Alleviate Excess Inflammation in Ulcerative Colitis of Geriatric Patients
Abstract One million Americans live with Ulcerative Colitis (UC), and 30% of that population is over 60. Thirty-eight thousand new cases are diagnosed yearly, with 15% over 65. Mor...
Mobius Accessibility Mounting System and Assistive Technology Product Line to Support Independence and Safety for Older Adults and Persons with Disabilities
Project Summary/Abstract The overwhelming majority of older adults, age 65 and over, want to age in place at home, but many reach a point in their lives where they can no longer li...
Hemostatic Bioadhesive Paste for Coagulation-Independent Rapid Control of Bleeding
ABSTRACT The objective of this proposal is to optimize and validate the hemostatic bioadhesive paste in compliance with FDA regulatory guidance for the FDA IDE approval in advance...
Super-resolution single-molecule sequencing by observing the dynamic hybridization of a repertoire of oligonucleotides to DNA targets
PROJECT SUMMARY/ABSTRACT The genome is a critical factor in our health. However, the cost and performance of current sequencing technologies are limiting genomics from realizing it...
Low-Cost Platform for Ultrasensitive Fluorescent Immunoblot
Abstract Western blot assays are fundamental tools used in biological and biomedical laboratories around the world. They have played a role in some of the most important discoverie...