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606,025 grants found
Showing 23,541 – 23,560 of 606,025 grants
Intranasal Insulin Administration as Medication for Alcohol Use Disorder
SUMMARY/ABSTRACT While there have been developments in treatments for alcohol use disorder (AUD), current pharmacotherapies face several limitations, including the presence of adve...
Genomic encoding of heterogeneity
Project Summary/Abstract In development, the embryo generates many cell types with distinct gene expression programs, leading to heterogeneity across cells. In cancer, mutation gen...
A novel closed-loop feedback neuromodulation system for improving slow wave sleep in Alzheimer's disease patients
Project Summary Abstract Sleep disturbances are a common facet of Alzheimer’s disease (AD) affecting 20-40% of patients in the mild to moderate stage of the illness. There is stron...
Chair to Prevent and Treat Pressure Injuries in Persons Living with Alzheimer's Disease and Related Dementias
Project Summary/Abstract The goal of the proposed project is to develop an innovative chair built with a calibrated pressure-shifting programmable surface to prevent and/or treat p...
Harnessing multi-omics to identify host-microbiome interactions driving HIV-associated chronic obstructive pulmonary disease in low and middle income countries.
ABSTRACT Chronic obstructive pulmonary disease (COPD) affects 300 million people and is the third leading cause of death globally, with >80% of these deaths occurring in low- an...
Personalized visualization tool to improve communication between clinicians, Latinos with ADRD, and their care partners
Project Summary Clear Session, Inc is partnering with UTHealth Houston to develop an innovative digital visualization solution to increase engagement among Latino ADRD, their careg...
Treating Balance Impairment of the Elderly with TMS-induced Brain Connectivity
Summary Falls and fall-related injuries are a growing public health concern, particularly in regions of the world in which high proportions of the population are elderly. When olde...
Circumventing the pharmacokinetic/pharmacodynamic limitations of antioxidant therapy for Parkinson's Disease by nose to brain delivery of N-acetylcysteine
Abstract Parkinson’s Disease (PD) is a neurodegenerative disorder that affects over 1 million U.S. citizens. PD is most often diagnosed in people over the age of 60, while only 4%...
Development of a Novel Alzheimer's Disease Therapeutic
PROJECT SUMMARY Alzheimer's disease is associated with multiple factors, including but not limited to amyloid plaque formation, tau protein entanglement, enzyme degradation an...
Non-toxic CNS drug delivery across the BBB in Alzheimer's and other dementias
Project Summary Alzheimer’s disease (AD) is the principal cause of dementia worldwide with its incidence anticipated to double every 20-years as the population ages. It represents...
Multi-target Peptide Drug for Alzheimer's Disease
Project Summary/Abstract: Alzarrok Bio is developing a peptide, derived from the human defense protein cathepsin G, as a multitarget drug for Alzheimer’s disease (AD). Existing dru...
Onward Door-Through-Door Companion Rideshare Technology to Improve Care for Older Adults and Individuals with Alzheimer's Disease and Related Dementias (AD/ADRD)
Abstract Social determinants of Health (SDoH) drive 80% of health outcomes and transportation is the third most prominent SDoH in the United States, impacting nearly all other soci...
Connection, Independence, and Circular Support: Prompted Health Awareness Enabled by the At-Home Health Station
ABSTRACT In 2020, the financial burden associated with the care and treatment of individuals afflicted by Alzheimer's disease (AD) and AD-Related Dementias (ADRD) amounted to...
Development of a blood-based test for neurodegenerative diseases
STTR Project Summary/Abstract It is estimated that every fourth to fifth death in the US is caused by a neurodegenerative disease such as Alzheimer’s, AD related diseases, or Parki...
Guided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)
PROJECT SUMMARY The objective of the proposed project is to develop a method called PAINT (Precise Area INtroduction and Transfection) for highly localized, versatile, and efficien...
Advancing computational modeling of disease metabolism by integrating AI and systems biology
Project summary Metabolic pathways are crucial for cellular energy and function. Dysregulated metabolism is a distinctive feature of various diseases, including cancer, diabetes, c...
Robust Statistical Methods for Longitudinal Microbiome Studies
PROJECT SUMMARY Large-scale longitudinal microbiome studies are increasingly common as they allow investigators to study temporal patterns of the microbiome, elucidating the forces...
Developing synthetic RNA organelles for spatiotemporal separation, control, and monitoring in living cells
Project summary Our understanding of biology is being transformed by the discovery and characterization of organelles arising from the spontaneous phase separation of proteins and...
Vinpocetine Mediation of Prior Fetal Alcohol Exposure
Project Summary/Abstract: There is a compelling need to develop treatments for mental deficiencies from fetal exposure to alcohol. The impairments are often lifelong and while earl...
Studying alcohol-associated liver disease and its interaction with rs738409 variant in PNPLA3 in a liver culture model
PROJECT SUMMARY Alcohol-associated liver disease (ALD), caused by excessive alcohol consumption, is a growing public health problem with a significant impact on the global populati...