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606,025 grants found
Showing 23,581 – 23,600 of 606,025 grants
Heart and Lung Outcomes Post-TB (HALO Post-TB)
ABSTRACT: HEART AND LUNG OUTCOMES POST-TUBERCULOSIS (HALO Post-TB) The global prevalence of post-tuberculosis lung disease (PTLD) is estimated to be ~50%, but our understanding of...
Deciphering the underlying mechanisms of craniofacial spliceosomopathies
PROJECT ABSTRACT Nager syndrome (OMIM#154400) is a rare craniofacial and limb disorder characterized by midface retrusion, micrognathia, absent thumbs, and radial hypoplasia. This...
External Facilitation to Increase Prescribing of AUD Medications in the Psychiatric Setting
ABSTRACT Patients with major mental illness (MMI; major depressive, bipolar, schizophrenia spectrum, other psychotic disorders; posttraumatic stress disorder) are diagnosed with al...
Serum Exosome Detection and Monitoring of Alcohol-Related White Matter Brain Pathology-Opportunities to Optimize Treatment and Monitoring of AUD-Related Organ and Tissue Damage in Diverse Populations
1 Chronic heavy or binge alcohol consumption damages the brain’s structural and functional integrity. These effects, in large measure, are caused by alcohol’s toxic and degenerativ...
Stem Cell-Derived Microfluidic Placenta Organoids
Project Summary The placenta performs important functions to ensure proper development of the fetus, including oxygen and nutrients exchange, waste product removal and hormone secr...
Synaptic circuit mechanisms underlying psilocybin's therapeutic effects in the stressed brain
PROJECT SUMMARY Psychedelics are chemicals best known for their ability to induce profound changes in the human conscious experience. After a several-decade hiatus, research on psy...
A prospective examination of TAC features as predictors of consequences and alcohol use disorders
PROJECT SUMMARY Young-adult alcohol misuse is a public health problem causing thousands of assaults, injuries, and deaths each year. Both college and non-college adults frequently...
Molecular and Circuit Mechanisms of Neurexin1-Mediated Goal-Directed Dysfunction
PROJECT SUMMARY Studies in humans suggest that Neurexin1α (Nrxn1α), a presynaptically expressed organizer of synaptic structure, is a key genetic risk factor for multiple neuropsyc...
Peer-Led Support Intervention for Black Breast Cancer Survivors
PROJECT SUMMARY Compared to non-Hispanic White women, Black women with breast cancer have a 41% higher mortality rate and experience worse psychosocial outcomes, such as greater ps...
Examining alcohol-induced blackouts in young adults using alcohol sensors
Project Summary Young adult drinking is a major public health problem. Approximately 1 in 3 report frequent heavy episodic drinking (4+/5+ drinks in two hours for females/males). O...
Barriers to Screen for Domestic Violence among Women in Emergency Department
PROJECT SUMMARY ABSTRACT Domestic violence (DV) includes physical and sexual violence, threats, economic, and emotional/psychological abuse, or other abusive behavior as part of a...
High-Content Screen to Identify Small Molecule Therapeutics that Reduce Aberrant Lipid Accumulation in APOE4 Alzheimer's Disease
Project Summary: Genome-wide association studies demonstrate that the top genes associated with increased risk for Alzheimer’s disease (AD) are involved in cholesterol and lipid me...
Alcohol assoCiated gut Dysbiosis and CVD in HIV (the AC/DC HIV study)
PROJECT ABSTRACT: Among people with HIV infection (PWH), hazardous drinking is a common, modifiable risk factor for cardiovascular disease (CVD) and death. Both alcohol and HIV cau...
Modernizing the family-based association testing (FBAT) approach and its software implementation in the FBAT-program
Developed for linkage and candidate gene studies, family-based association tests (FBATs) have played a fundamental role in the disease mapping efforts of the human genome project....
Trans-Omics for Precision Medicine (TOPMed) Artificial Intelligence Coordinating Center (AI-CC)
ABSTRACT Please see the Volume 1. Technical Proposal. 1. Background and Purpose The Women’s Health Research Initiative (WHRI) recognizes that women have historically been underrepr...
Computational Methods for Systems Genetic Analysis of Rare Polygenic Disorder
Idiopathic Pulmonary Fibrosis (IPF) inflicts a significant healthcare burden and high rate of mortality in the U.S. Current treatment options can slow the rate of lung function dec...
Technology-based Sleep Self-Management Intervention for Adults with Subarachnoid Hemorrhage
PROJECT SUMMARY/ABSTRACT Subarachnoid hemorrhage (SAH) accounts for 27% of all stroke-related years of potential life lost before 65-years of age. Sleep disturbance (insufficient s...
Alternative polyadenylation in Right Ventricular Fibrosis
Project Summary: Pulmonary hypertension (PH) is a cardiovascular disorder characterized by high mortality, primarily due to right ventricular (RV) failure (RVF) caused by increased...
Psychosocial and cultural determinants of cardiometabolic health among older Chinese Americans
Project Summary Cardiometabolic diseases contribute to more than 1 in 4 deaths in U.S. adults, including Asian Americans. Psychosocial stress is believed to be a key risk factor le...
Mechanisms of right ventricular dysfunction in type 2 diabetes
PROJECT SUMMARY Heart failure in the presence of diabetes is common, expensive, and growing in significance, with some estimates suggesting that diabetic cardiomyopathy is present...