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606,025 grants found
Showing 23,521 – 23,540 of 606,025 grants
Unravel the mechanics for bacteria
The National Institutes of Health (NIH) estimated that bacterial biofilms are involved in 65% of microbial diseases and in more than80% of chronic infections. Most of the existing...
Physics Informed Neural Networks for Gas Turbine Applications
The physical world around us is profoundly complex, and for years, researchers have sought to develop a deeper understanding of how it functions. Building models capable of predict...
Defining protective antibody responses induced by the novel RH5.2-VLP malaria vaccine
OverviewThe world urgently needs an effective malaria vaccine. Malaria is a devastating disease, infecting 247 million people and causing 619,000 deaths in 2021 alone. Alongside ma...
Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders
PROJECT SUMMARY The cardiac conduction system (CCS) is specialized in the generation and propagation of electrical impulses from the atria to the ventricles to produce a highly coo...
Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia
Project Summary Synaptic loss is theorized to occur early in the course of common neurodegenerative proteinopathies such as Alzheimer disease (AD) and Lewy body dementia (LBD). Unt...
Investigation of the Functional Roles of MicroRNA-320 in Skeletal Muscle
PROJECT SUMMARY/ABSTRACT Disuse, denervation, and several diseases result in skeletal muscle atrophy and weakness – a major contributor to disease-related disability and death. The...
Neuroimmune Genomic Profiling of Alzheimer's Disease
Summary Molecular-genetic studies have illuminated the primary pathway of Alzheimer’s disease (AD). However, a relatively long chronic prodromal period of the disease, and the casc...
Single telomere length analysis using DNA array and FISH: a low-cost and accurate test for telomere-associated diseases
ABSTRACT Telomere-associated diseases, including telomere biology disorders (TBD), are prevalent among the aging population. TBD represent a group of most common premature aging sy...
Automated System for Detecting and Reporting Lapses in Performance of Activities of Daily Living for Independent and Cohabitating Persons with Alzheimer's Disease and Related Dementias
Project Abstract In this SBIR Phase I project, ASTER Labs will significantly enhance an innovative system able to accurately detect Activities of Daily Living (ADL) performed by pe...
Trans Spinal Delivery of a Targeted Nanoformulation of Curcuminoids to Treat AD
Technical Abstract Neurodegenerative disorders affect over 40 million people worldwide and most, if not all, are mediated by inflammation. Even though several drugs are approved by...
LifeBioTALK: Digital Engagement with a Pre-Scripted Avatar for People with Alzheimer's Disease to Reduce Challenging Behaviors and Caregiver Burden
Project Summary/Abstract LifeBio develops agetech for care management of people with dementia (PWD). In this proposed SBIR Phase I, we will build out the prototype of LifeBioTALK,...
Novel brain-penetrant drugs for translation-targeting therapeutics of Alzheimer’s disease
Abstract Alzheimer's disease (AD), the most common form of dementia in older adults, is a neurodegenerative disorder characterized by progressive decline of memory and cogniti...
Slippery, Omniphobic Coating to Prevent Thrombosis and Biofilm Formation on Peripheral Vascular Grafts
PROJECT SUMMARY Critical limb ischemia (CLI) affects 2 million Americans with peripheral artery disease (PAD) each year and is a frequent cause of persistent ulcers and wounds, amp...
Vagal-hypothalamic modulation of alcohol intake
Abstract Alcohol use disorder (AUD) is the third leading cause of preventable death in the U.S. and 32.6 million adults have AUD. AUD etiology is highly diverse and current treatme...
Dynamic nanoscale cellular imaging via time-resolved cryo-vitrification
Summary: Many cellular processes are triggered by ligands such as ions, small molecules, peptides/proteins (e.g., hormones, cytokines), and viruses. However, rapid cellular adaptat...
Influence of early life physical inactivity during a key period of postnatal development on adult muscle quality – from matrix to mortality
Project Summary The physical inactivity (PIA) epidemic has far-reaching negative health impacts on adults, but even more so on children, who are facing more PIA than ever in divers...
FIU-Diversity Center for Genomic Research (FIU-DCGR)
FIU Diversity Center for Genomic Research (FIU-DCGR) Abstract Florida International University (FIU) is in Miami-Dade County, Florida, a county with a population of 2.7 million (20...
Role of Brain Aromatase in Alzheimer's Dementia: Sex differences and the Preventive Therapy using Pulsed Photobiomodulation
Abstract Alzheimer's disease (AD) is a growing global health concern that disproportionately impacts women. Additionally, patients with aromatase/estrogen receptor inhibitors...
Manganese exposure and genetic diversity in risk mechanisms for neurodevelopmental disorders
ABSTRACT The broad, long-term objectives of the grant are to increase our understanding of the mechanisms underlying the gene x environment interactions that link developmental man...
Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets
Project Summary There is no cure for osteogenesis imperfecta (OI or brittle bone disease), a group of heritable genetic disorders affecting 1:15,000 births. The most evident clinic...