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The Lost Navy: Sweden's "blue" heritage c. 1450-1850
Vasa, Kronan and Mars are the most famous Swedish warships, and well-researched shipwrecks.But they are only a few of a unique range of early-modern naval ships, most of which were...
The establishment, growth and legacy of a settler colony: Quantitative panel studies of the political economy of the Cape Colony.
In the 16th to 18th centuries European colonized large parts of the world. Several scholars argue that the legacies of these processes are notable even today.While we know the outc...
A new approach to measuring the wealth of nations: understanding long-run economic growth using historical aerial photographs
To understand how to promote growth, alleviate poverty, and reduce inequality, we need measures of wealth that are both disaggregated over space and available over long time period...
Ways Through Medieval Rome [Swedish Institute in Rome]
The medieval Latin manuscript no. 326 in the Abbey Library of Einsiedeln, Switzerland, is the single most important textual source for the topography of Rome in the Middle Ages. It...
On Fertility and Inequality: Evidence from IVF treatments
To what extent do differences in fertility (child-bearing) generate inequality?Studies have shown that fertility is associated with women’s labour market trajectories, wealth, chil...
Non-invasive risk stratification and prediction of outcome in patients with arrhythmic disorders and risk for sudden death
Background:Risk stratification in patients predisposed to cardiac arrhythmias and at risk for sudden death is an unmet clinical challenge. Electrocardiography offers a non-invasive...
Rehabkompassen - ett patientcentrerat digitalt uppföljningsverktyg för att möjliggöra en jämlik strokevård - En pragmatisk randomiserad kontrollerad multicenterstudie
Bakgrund:Stroke är den vanligaste orsaken till funktionsnedsättning hos vuxna med stora samhällskostnader som följd. En effektiv lösning på strukturerad uppföljning behövs enligt S...
Are the students’ scores in PISA valid? A comparison with students’ grades and national test results
PISA has an extensive impact on policymakers, academics and the wider education community – but are the results valid? The overall aim is to investigate the validity of the test sc...
integrating Metabolism ENvironment and Diet for sub-phenotyping of obstructive lung disease (iMEND)
Bakgrund:Obstructive lung disease is an increasing global health problem of pandemic proportions, with COPD alone affecting >10% of the population. COPD and asthma are umbrella...
Host immune mechanisms underlying the interaction of Diabetes and Tuberculosis
Bakground:Tuberculosis (TB), caused by infection with M tuberculosis, is a major global health problem killing around 2 million individuals per year. Diabetes (DM) increases the ri...
Fungal colonization and infection in Cystic Fibrosis prevalence, consequences and intervention
Bakgrund:Cystisk fibros (CF) är en letal autosomalt recessivt ärftlig sjukdom. Intensifierad multifaktoriell symptomatisk behandling har ökat överlevnaden från 6-8 år på 60-talet,...
GUT MICROBIOTA IN OBESITY, TYPE 2 DIABETES AND CORONARY HEART DISEASE IN 12,200 SWEDES
BACKGROUND: Despite evidence supporting a role for the gut microbiome in obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD), causal- and mechanistic evidence in humans...
Disarming exorbitant neutrophil responses using aerosolized Dnase I/Pulmozyme in COVID-19 associated acute respiratory distress syndrome; a phase-II trial.
Background:COVID-19 results in acute respiratory distress syndrome (ARDS) and can be fatal. The role of neutrophils, the most important innate immune cell type in exacerbations dur...
Biomarkörer för en ökad förståelse och bättre behandling av förmaksflimmer
BackgroundAtrial fibrillation (AF) confer substantial morbidity and health care costs due to increased risk of stroke and death. The treatment recommendations in AF are based on in...
Phosphorylcholine in atherosclerosis and immunity
BackgroundAtherosclerosis is a chronic inflammatory condition and the plques are characterized by accumulation of dead cells, oxidized LDL (OxLDL) in foam cells and activated immun...
Genetisk benägenhet för svår covid-19
Bakgrund:I Sverige är över 35 000 konstaterade smittade med SARS-CoV-2 och över 4 200 har avlidit i covid-19. Över 2 000 personer har vårdats på intensivvårdsavdelning för sjukdome...
Finding novel causes and new cases of hereditary dyslipidemia in Sweden - clinical, genetic and experimental studies
Bakgrund:Monogenic dyslipidemias are common (~2% of the population) and have a high risk for premature cardiovascular disease. Familial hypercholesterolemia (FH) is present in ~50,...
Lung Involvement in Rheumatoid Arthritis from initiation to chronic disease (LIRA study)
Background: Autoantibody-positive (seropositive) rheumatoid arthritis (RA) is a disease where autoimmunity appears many years prior to clinical onset. In contrast to others autoimm...
Inverkan av behandling med konstdjord lunga (extrakorporal membranoxygenering) på kärlmotståndet i lungkretsloppet och höger hjärtkammarens funtkion hos grisar.
Bakgrund: During severe hypoxaemic respiratory failure, e.g. severe ARDS, increased pulmonary vascular resistance (PVR) may partially be caused by hypoxic pulmonary vasoconstrictio...
Långtidseffekter av e-cigarettanvändning på luftvägshälsa och förändring av rökvanor i befolkningen
Bakgrund: Det pågår en debatt huruvida nya nikotinprodukter såsom e-cigaretter kan tillämpas som harm reduction, det vill säga att rökare skulle rekommenderas att byta till e-cigar...