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Spatial multiomics to decode and target the non-random metastatic behavior of three common malignancies
Until recently, research on clinical metastases has been hindered by often too sparse metastatic tumor material and previous technical limitations. This has made credible analysis...
Neuronal networks of the vertebrate motor system - evolutionarily conserved forebrain control strategies.
Our overarching goal is to unravel the forebrain mechanisms that determine which motor behaviour to select.The pallium/cortex and basal ganglia of the lamprey are conserved regardi...
Towards inclusive and precision treatment of gestational diabetes and improved maternal and offspring health with a digital platform
Purpose and aim: Gestational diabetes (GDM) is an increasing public health problem. Also, the prevalence is higher among foreign-born women.This project aims to improve self-manage...
Mechanisms and consequences of mucus in asthma: new strategies for prevention of airway obstruction and inflammation
Excessive mucus production poses a significant threat in asthma by accumulating in the respiratory tract and limiting airflow.Previous asthma research has revealed persistent mucus...
Motor-ACT: Motor aspects and activities in relation to cognitive decline and brain pathologies
Early detection of those at risk of cognitive decline/dementia is a global goal. Brain pathologies occur decades before dementia but require invasive technology to detect.Decreased...
Mechanisms of tissue-specific disease tolerance in genotoxigenic bacterial infection
Disease tolerance, defined as limiting tissue damage without influencing pathogen load, is a component of the innate host response to infection.However, knowledge about the host me...
Studies of neutrophils in autoimmune joint inflammation
Neutrophils are the most abundant cells found in inflamed joints of patients with rheumatoid arthritis (RA), and animal models identify a central role for neutrophils in autoimmune...
Inequality and the Environment Beyond Homo Economicus
Inequalities measured in terms of income and wealth have increased substantially in recent decades, which has spurred a renewed interest in the measurement of inequality per se as...
Sustainimal 2.0
SustAinimal 2.0 will investigate roles of livestock for future increased, sustainable and competitive food production in Sweden.Focus will be on solutions for future food productio...
Personalized anti-fracture treatment
With increasing age of the population, Sweden and industrialized countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considera...
CADASIL: Therapy development and novel biomarkers
CADASIL is the most common monogenic form of cerebral small vessel disease (SVD), a group of diseases affecting more than 5.000 individuals per year in Sweden.CADASIL is caused by...
The molecular portfolio of the extraocular muscles: keys to protection in muscle disease
The extraocular muscles (EOMs) are remarkably resistant to muscle dystrophies, despite having the same gene defect that affects all body muscles leading to severe handicap and prem...
Conquering forever chemicals: Simultaneous elimination of Per- and polyfluoroalkyl substances (PFAS) and their precursors from contaminated soil
Per- and polyfluoro-alkyl substances (PFAS) are extremely stable synthetic chemicals that have been employed for decades in various industries. The application of PFAS-containing f...
Strengthening process and outcomes of psychotherapies and leveraging academic-, policy-, and clinical partnerships to develop Routine Monitoring System in Kenya (SPARK)
ObjectiveThe efficacy of mental health interventions within sub-Saharan African settings remains underexplored. The proposed SPARK project seeks to illuminate the pathways for enha...
Deciphering metabolic crosstalk between adipocytes and endothelial cells to prevent obesity-associated diseases
Obesity remains the major risk factor for developing metabolic disease.Numerous studies have shown that maintaining adipose tissue functionality is enough to prevent metabolic dise...
The organization and function of specialized dopamine-striatal circuits.
Action selection, decision-making and cognitive flexibility are critical brain functions for humans and other animals in order to thrive and survive in a complex environment.The fr...
Assessing biochar stability in soils in the context of climate change using a novel approach: tree ring “bomb carbon” biochar
Biochar has attracted attention for its potential to improve soil fertility and sequester carbon (C). The biochar market is expanding, both in Sweden and globally.This project aims...
Who Wants to be a Working Retiree? Prerequisites and Working Conditions for People Combining Work and Retirement in the Temporary Staffing Sector
Research problem and specific questionsThis project explores the employment landscape of non-standard employment (NSE) tailored for working retirees in Sweden, focusing on the temp...
Broken barriers: the impact of mitochondrial introgression on the life-history and behaviour of threatened Atlantic salmon
The viability of wild populations is increasingly threatened by human-mediated gene flow between previously isolated groups.One crucial, but overlooked, consequence of human-mediat...
BioAIUnlock: Identification of stress-resistant anaerobic microorganisms to unleash the potential of lignocellulosic biomass in future biorefineries
In the rapidly changing international context, advancing Sweden towards a sustainable, fossil-free future is imperative.Anaerobic digestion (AD) of lignocellulosic biomass, key for...