Mechanisms and consequences of mucus in asthma: new strategies for prevention of airway obstruction and inflammation

Excessive mucus production poses a significant threat in asthma by accumulating in the respiratory tract and limiting airflow.

Previous asthma research has revealed persistent mucus plugs that remain in the lungs for years, indicating a local reprogramming of mucus-producing goblet cells.

However, a molecular definition of pathological goblet cell function in the lung is still lacking.The composition and functional properties of mucus significantly differ in asthma compared to healthy lungs.

My preliminary data suggest that, in addition to physically obstructing the airway, altered mucus dynamics directly impact the development and persistence of airway inflammation.Currently, limited knowledge exists regarding mucus regulation in the airway and its influence on lung immunity.

To address this gap, my research proposal will apply cutting-edge goblet cell and mucus analytical tools to pre-clinical models of asthma and 3D cultures of differentiated airway cells. This approach will help dissect goblet cell dysfunction and reveal mucus-immune-cell interactions.

Additionally, in-depth molecular profiling of human airway samples will identify mucus alterations associated with airway obstruction and distinct inflammatory features in asthma.

Achieving these objectives will enhance our understanding of fundamental asthma mechanisms and lead to the identification of novel therapeutic strategies to prevent airway obstruction and inflammation.