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606,025 grants found
Showing 36,081 – 36,100 of 606,025 grants
Efficient red-to-NIR photo-uncaging and applications in therapy
PROJECT SUMMARY Many light-responsive systems have been produced via natural evolution, including opsins, and phytochromes, while chemists have added to the list of light-responsiv...
Mount Sinai StARR Program - NIAID
Project Summary The number of physician-scientists in the United States has decreased from its peak of 5% in 1980 to 1.5% today. This decline particularly threatens Pediatrics and...
A clinician-in-the-loop smart environment to support management of chronic health conditions
PROJECT SUMMARY / ABSTRACT As the population of individuals 65+ grows, so too will the number of individuals who struggle to manage chronic health conditions. Exacerbations, or sud...
ExpLoiting thErapeutic VulnerAbilities in hepaTocEllular carcinoma (ELEVATE)
OVERALL: SUMMARY Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with bleak outcomes. With the alarming rise in global obesity incidence, obes...
Administrative Core
CORE 1 – ADMINISTRATIVE CORE: SUMMARY The overall goal of this P01 program project grant (PPG) application, titled ELEVATE, is to evaluate novel therapeutic approaches for hepatoce...
Bile Acid-Mediated Signaling In HCC
PROJECT 1: SUMMARY Hepatocellular cancer (HCC) is a rising cause of cancer-related mortality. Nonalcoholic fatty liver disease (NAFLD), especially its aggressive form, nonalcoholic...
Cooperation of Co-Amplified Genes in Hepatocellular Carcinoma
PROJECT 2: SUMMARY Hepatocellular carcinoma (HCC) is a highly fatal disease with an alarming increase in incidence and mortality. Obesity-induced non-alcoholic steatohepatitis (NAS...
A Novel Target in The Tumor Myeloid Compartment for Hepatocellular Carcinoma
PROJECT 3: SUMMARY Given the limited clinical benefits of the current treatments for hepatocellular carcinoma (HCC), there is an urgent need for novel approaches to improve patient...
Designer Cytokine Therapy of Hepatocellular Carcinoma
PROJECT 4: SUMMARY Innovative therapeutic strategies are warranted to treat hepatocellular carcinoma (HCC), which is one of the most common malignancies worldwide with current appr...
Mouse Model and Pathological Analysis Core
CORE 2 - MOUSE MODELS AND PATHOLOGICAL ANALYSIS CORE: SUMMARY The purpose of Core 2 is to support the research of each of the projects in the ELEVATE program project grant (PPG) by...
Biostatistics and Bioinformatics Core (BBC)
CORE 3 - BIOSTATISTICS AND BIOINFORMATICS CORE: SUMMARY The overarching goal of the ELEVATE program project grant (PPG) is to leverage molecular abnormalities in hepatocellular car...
Functional Consequences of Early Childhood Otitis Media
PROJECT SUMMARY/ ABSTRACT Auditory deprivation during childhood has serious consequences on all aspects of development. Otitis media (OM) is a highly prevalent condition in young c...
The molecular epidemiology of enteropathogenic (EPEC) and enteroaggregative (EAEC) Escherichia coli among adult patients in Seattle
PROJECT SUMMARY/ABSTRACT Infectious gastroenteritis is a leading cause of morbidity and mortality worldwide. Diarrheagenic E. coli (DEC), particularly enteropathogenic (EPEC) and e...
Antibody bound bacteria during HPV infection and cervical dysplasia
PROJECT SUMMARY High-risk human papillomavirus (HR-HPV) is a known cause of >95% of cervical cancer and cervical intraepithelial neoplasia (CIN). Prophylactic vaccines are avail...
Precision Tumor Sampling of Melanoma Using Laser Microbiopsy
ABSTRACT Melanoma is the fifth most common cancer in the US with almost 100,000 cases estimated for 2023. Late-stage disease has a five-year survival of just 30%, resulting in almo...
The Young Empowered Scientists for ContinUed Research Engagement (YES for CURE) Program at the Dana-Farber/Harvard Cancer Center (DF/HCC)
YES for CURE Project Summary Increasing the participation and retention of underrepresented minorities in cancer-related STEM fields is critical for eliminating cancer disparities...
IRACDA at Texas A&M University
PROJECT SUMMARY IRACDA@TAMU is a partnership between Texas A&M University (TAMU), a historically white R1 university that has recently achieved the status of a Hispanic-Serving...
Paradigm Shift in the Management of Patients with Previously Untreated Chronic Lymphocytic Leukemia through NCI-sponsored Clinical Trials
PROJECT SUMMARY Dr. Parikh is a consultant in the Division of Hematology, Department of Medicine at Mayo Clinic in Rochester, MN, and holds the rank of Associate Professor of Medic...
Targeting the tumor microenvironment with engineered CD4+ T cells
Abstract Novel immune therapies are needed to help the majority of patients with melanoma and other solid tumors who fail to benefit or stop responding to immune checkpoint inhibit...
RSMI HEALS
Project Summary/Abstract There are 26 million limited English proficient (LEP) people in the U.S. population (those who speak English less than “very well”); the two most frequentl...