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606,025 grants found
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Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging Tools
Project Summary A causal hallmark of brain aging and Alzheimer’s Disease (AD) is loss of proteostasis, the maintenance of proteome health through several processes, including proti...
Assessing and Promoting Vaginal Health for Transgender Men on Testosterone: A Mixed Methods Study
PROJECT SUMMARY/ABSTRACT The overall goal of this K23 proposal is to provide Olivia Van Gerwen, MD, MPH with the necessary mentorship and career development to become an independen...
Novel gene regulatory networks underlying two specialized modes of craniofacial development in a new model system of pupfishes
Project Summary The study of the genetic basis of craniofacial adaptations in naturally divergent groups of species can provide an opportunity to uncover novel gene networks and ge...
Factors Shaping the Genomic Spectrum of Structural Variants
PROJECT SUMMARY/ABSTRACT Despite decades of research into mechanisms of double-strand break (DSB) repair, factors shaping the outcomes of defective repair remain poorly understood....
Understanding the pathogenesis of classic Hodgkin lymphoma in persons living with HIV through conventional and spatial transcriptomics
PROJECT SUMMARY/ABSTRACT The incidence of hematological malignancies is higher in persons living with PLWH (Persons living with HIV (Human Immunodeficiency Virus)). The risk of dev...
Regenerative and Rehabilitation Strategies to Reduce Inflammation Following Volumetric Muscle Loss Injury
PROJECT SUMMARY Current soft tissue repair techniques have not been able to reverse the pathological changes that occur following volumetric muscle loss (VML) injury. The key event...
DeepTOBIDx: deep learning-enhanced multimodal diagnostic breast imaging
PROJECT SUMMARY / ABSTRACT Imaging modalities routinely used in the diagnostic workup, i.e., mammography, ultrasound, and MRI, can catch breast cancers at an early stage based on s...
Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behavior
ABSTRACT Human parents and non-parents show sharply distinct patterns of brain activity in response to infant cries or laughter. How is this change in brain responses accomplished?...
Post-transcriptional control of gene expression by the mTORC1 signaling pathway
Project summary The translation of mRNAs into protein is a fundamental step in gene expression that is regulated by diverse cellular signals. How these regulatory mechanisms are us...
Multi-scale, multi-modal imaging assessment of trajectories of cognitive impairment in Multiple Sclerosis
Cognitive impairment is highly prevalent in patients with multiple sclerosis (MS) and increases in severity with disease progression. Unfortunately, treatment options for MS-relate...
Open-Source Software Tools for Rapid Radiofrequency Coil Modeling and Simulation in MRI
Project Summary The aim of this project is to develop a novel, rapid, and memory efficient open-source software for radiofrequency (RF) coil modeling in magnetic resonance imaging (...
Novel Designed Multi-Ligands as Tocolytics for Dysregulated Myometrial Pathways in the Treatment of Preterm Labor
PROJECT SUMMARY ABSTRACTPreterm birth is a major medical problem resulting in disability and death for very preterm infants. Therapeutic approachesto manage preterm labor are off-l...
TMJ Disc Regeneration
Patients opting for TMJ disc removal face issues due to the absence of FDA-approved replacements, leading to bone-to-bone contact and subsequent joint problems. Autografts, like de...
Revealing New Therapeutic Opportunities for Kidney Glomerular Diseases by Elucidating the Mechanobiological Functions of Novel Cytoskeletal Structures in Podocytes
Project Summary Chronic kidney diseases, of which glomerular diseases form the most significant component, are quite common and estimated to affect from 5 to 11% of the population....
Non-ISGylated HIV proteins are sorted to hepatic exosomes to activate liver fibrosi
In an era of improved survival due to modern antiretroviral therapy (ART), liver disease has become a major cause of morbidity and mortality among HIV-infected persons causing deat...
Ambient Temperature Molecular Detection of Sexually Transmitted Infections from Vaginal Swabs on a Power-free Device
ABSTRACT Despite being easily treatable, STIs such as Chlamydia (infection with Chlamydia trachomatis) and Gonorrhea (infection with Neisseria gonorrhoeae) represent the majority o...
Shape-Adaptive Cochlear Implant Electrode Arrays
Project Summary/Abstract During this Phase I SBIR effort, we will assess the viability of shape-adaptive cochlear implant (CI) electrode arrays as a new solution for achieving atra...
Enhanced Seasonal Influenza Vaccine Targeting Variable and Conserved Antigens
PROJECT SUMMARY The currently marketed seasonal influenza vaccines have considerable impact on disease, but their efficacy relies on successfully matching the vaccine strains to fu...
Elucidating circuit mechanisms of brain rhythms in the aging brain
PROJECT SUMMARY Brain rhythms coordinate the activities of thousands of neurons across multiple brain areas for complex cognitive functions. The hippocampal theta (4-12 Hz) rhythm,...
Sustainable marine power generation and hybridisation
Since 2019 we have successfully developed and launched our award winning, innovative Integrel e-power and e-drive products into the leisure marine market. The existing product rang...